TNFalpha -308 C-->t and -863 C-->a polymorphisms and spermiogram characteristics.

Abstract:

BACKGROUND:Genetic factors may play a role in male infertility. METHODS:In a prospective case-control study, we assessed the allele and genotype frequencies of the TNFalpha -308 C-->T and -863 C-->A polymorphisms, detected by PCR of sperm DNA, of 577 Caucasian men recruited in an infertility clinic. Semen sampling was performed and spermiogram results were correlated to genetic data. RESULTS:The allele frequencies of the TNFalpha -308 C-->T and -863 C-->A polymorphisms were not significantly different between non-normozoospermic (n = 447) and normozoospermic (n = 130) men [758/894 (85%) and 134/894 (15%) vs. 213/269 (82%) and 43/260 (18%), p = 0.5, odds ratio (OR) 1.1, 95% confidence interval (CI) 0.74-1.76, and 749/894 (84%) and 145/894 (16%) vs. 212/260 (82%) and 48/260 (18%), p = 0.4, OR 1.2, 95% CI 0.78-1.76, respectively]. The genotype frequencies of the TNFalpha -308 C-->T and -863 C-->A polymorphisms were also not significantly different between non-normozoospermic and normozoospermic men. In addition, mutant alleles were not overrepresented in subgroups of men with the oligoasthenoteratozoospermia syndrome and asthenozoospermia. CONCLUSION:The TNFalpha -308 C-->T and -863 C-->A polymorphisms are not associated with spermiogram characteristics and do not represent molecular markers for genetic susceptibility to male infertility.

journal_name

Gynecol Obstet Invest

authors

Kurz C,Bentz EK,Denschlag D,Berner I,Keck C,Tempfer CB,Pietrowski D

doi

10.1159/000126494

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

63-7

issue

1

eissn

0378-7346

issn

1423-002X

pii

000126494

journal_volume

66

pub_type

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