Abstract:
BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were allowed to receive chemosensitization and not more than one prior chemotherapy regimen excluding taxanes. Docetaxel 35 mg/m2 was administered intravenously weekly for 3 weeks followed by 1 week off until disease progression or adverse effects prohibited further therapy. RESULTS:Ten patients were entered into this study, all of who were evaluable for toxicity and response. A median of 2 cycles (range 2-6) were administered. The most frequent drug-related toxicities were anemia and fatigue. There were no objective responses. Three patients had stable disease up to 6 cycles. One patient died of exsanguination from a known vaginal metastasis after completing her second cycle. The median progression-free interval was 1.7 months (range 0.9-5.8) and overall survival was 6.9 months (1.6-23.7). CONCLUSIONS:Docetaxel has limited activity in patients with recurrent cancer of the cervix at the dose and schedule tested.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Pearl ML,Johnston CM,McMeekin DSdoi
10.1159/000106489subject
Has Abstractpub_date
2007-01-01 00:00:00pages
193-8issue
4eissn
0378-7346issn
1423-002Xpii
000106489journal_volume
64pub_type
杂志文章abstract::We developed a model in which full-thickness human genital mucous membranes (fallopian tubes, endometrium) were heterotopically xenografted into the skin of severe combined immunodeficient (SCID) mice. The transplanted tissue retained its human phenotype for at least 4 weeks including the glandular epithelium, the lam...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292314
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Urinary bladder endometriosis is a severe form of endometriosis often requiring surgery. The several cases treated at our hospital in recent years has led us to evaluate the incidence of urinary bladder endometriosis in Finland. METHODS:We performed a register-based analysis of incidence of urinary bladder e...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000288161
更新日期:2010-01-01 00:00:00
abstract:AIMS:The study aimed to compare the clinical course and disease severity between culture positive and culture negative patients with intra-uterine devices (IUD)-associated pelvic inflammatory disease (PID). METHODS:A retrospective study of all IUD-associated PID patients admitted to tertiary medical center between 201...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000490666
更新日期:2019-01-01 00:00:00
abstract::We examined the fetal circulatory responses to maternal blood loss in pregnant women during the third trimester. Seven healthy women with placenta previa and singleton pregnancies underwent phlebotomies in an autologous donation program. Four hundred milliliters of blood was collected within 15 min at 34 and 35 weeks ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052915
更新日期:2001-01-01 00:00:00
abstract::During a 9-year period 61 Israeli Jewish Patients with histologically confirmed invasive squamous cell carcinoma of the uterine cervix (SUC) were treated by irradiation alone. A large proportion of the patients (44.2%) were more than 60 years old and only 27.9% were diagnosed as having stage IB disease. This is attrib...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299404
更新日期:1983-01-01 00:00:00
abstract::Monochorionic triplet pregnancies are very rare. Here we report 2 cases of multiple pregnancies with monochorionic triplets following intracytoplasmic sperm injection (ICSI) and day 3 embryo transfer. The 2 women concomitantly underwent controlled ovarian hyperstimulation due to male factor infertility. Following oocy...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000076786
更新日期:2004-01-01 00:00:00
abstract::Fetal echocardiographic and Doppler ultrasonographic prospective studies were performed in utero on 299 babies delivered at Hirata Municipal Hospital, Shimane, Japan, from May 1984 to June 1986. Two or three ultrasonographic examinations were performed on each fetus from 20 weeks of gestation to term. Three congenital...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293682
更新日期:1988-01-01 00:00:00
abstract::To the best of our knowledge, this is the first report of in vivo endometrial estrogen and progesterone receptor induction as a result of tamoxifen exposure in a postmenopausal breast cancer patient. The following observations, that the postmenopausal endometrium is sensitive to tamoxifen, that this agent can act as a...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292464
更新日期:1994-01-01 00:00:00
abstract::The relative roles of the cyclic nucleotide messengers cAMP and cGMP in the suppression of follicle-stimulating hormone (FSH) secretion in response to inhibin (IBN) were assessed employing rat gonadotropes in monolayer culture. While exposure of cells to gonadotropin-releasing hormone (GnRH) induced a significant incr...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298808
更新日期:1987-01-01 00:00:00
abstract::Women with Kartagener's syndrome (KS) are at a risk for infertility because of the dyskinetic ciliary activity in the fallopian tubes. In vitro fertilization - embryo transfer (IVF-ET) is considered the treatment of choice for patients with tubal factor infertility. In the literature only 2 patients with KS were treat...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106503
更新日期:2008-01-01 00:00:00
abstract::The success rate after intraperitoneal insemination is also imputed to superovulation protocols. We report here the first case, to our knowledge, of pregnancy following intraperitoneal insemination during a natural cycle. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293342
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:Limited information is available regarding the quantity of blood loss associated with uncomplicated transvaginal oocyte retrieval. The aim of the present study was evaluating the quantity of such a loss. METHODS:One hundred and fifty consecutive women undergoing oocyte retrieval were recruited. They un...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000158649
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Little is known about proper interval periods between the flushings of totally implantable access ports after completion of chemotherapy. Manufacturer guidelines recommend flushing catheters every 4 weeks. METHODS:This retrospective study examined whether flushing less than every 4 weeks conferred any benef...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294919
更新日期:2010-01-01 00:00:00
abstract::In vitro production of progesterone and estradiol by human corpora lutea of different ages was evaluated in the presence or absence of human chorionic gonadotrophin (HCG). Progesterone production by the luteal tissue was enhanced by as little as 0.1 IU/ml HCG and maximally stimulated by approximately 10 IU/ml HCG. Est...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293698
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:Perinatal environmental exposure may affect fetal development and reprogram the developing organism for adult-onset disease. In this case-control study, we aimed at assessing this pathogenetic model in endometriosis. METHODS:Consecutive patients with a first laparoscopic diagnosis of endometriosis were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000323531
更新日期:2011-01-01 00:00:00
abstract::The essential metal copper, zinc and iron content in starved virgin and pregnant rat tissue has been studied. The copper content of the whole rat, which was actually increased in pregnant rats, decreased in starved pregnant rats. The differences were significant in 19-day pregnant rats. The total copper content of the...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293737
更新日期:1988-01-01 00:00:00
abstract::The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of anti...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000074103
更新日期:2003-01-01 00:00:00
abstract::Immunocytochemical study in paraffin sections of human endometrium showed that the receptor contents for both oestrogen and progesterone receptors were lower than in the frozen sections although the staining patterns were similar in these two section types. Pretreating the specimens with proteolytic enzymes like tryps...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292422
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To determine whether a diminished intrapartum amniotic fluid volume represents a risk of adverse neonatal outcome when it occurs in conjunction with prolonged labor. METHODS:The intrapartum amniotic fluid index (iAFI) was measured in 242 parturients over 35 weeks of gestation during 1st-stage labor, and the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000049402
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to compare the levels of maternal blood lipids, placental and venous blood lipid transporters, and inflammatory factor receptors in pregnant women with and without gestational diabetes mellitus (GDM). We also aimed to figure out the relationship between these values and neonatal weigh...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000510032
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND/AIMS:To assess whether patients prefer surgery or a pessary as treatment for pelvic organ prolapse (POP). METHODS:A structured interview was performed among treated and untreated women with POP. We conducted fictive scenarios of potential disadvantages of surgery and pessary use. Our main outcome was the wi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000336634
更新日期:2012-01-01 00:00:00
abstract::Serum calcium, inorganic phosphate and heat-labile alkaline phosphatase (HLAP) have been estimated in maternal and cord sera of 120 pregnant women at labour. 75 women who did not take any vitamin D supplements during pregnancy showed statistically significant hypocalcaemia, hypophosphataemia and elevation of HLAP. Hyp...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299597
更新日期:1981-01-01 00:00:00
abstract:AIM:We investigated whether there is a correlation between morphological changes of the lower uterine segment after caesarean section (CS), visualized by means of either a transvaginal sonography (TVS) or a sonohysterography (SHG), and the frequency of abnormal uterine bleedings reported by the women. METHODS:By means...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000091497
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:A hypoxic environment is known to be essential for early placentation. A low oxygen tension induces hypoxia-inducible factor-1 (HIF-1alpha) which may play an important role as a transcription factor in maintaining the proliferative and undifferentiated phenotype in human trophoblasts. METHODS:We analyzed th...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000097634
更新日期:2007-01-01 00:00:00
abstract::Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. They can also be found in the blood of healthy non-pregnant women and in the seminal fluid o...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298985
更新日期:1985-01-01 00:00:00
abstract::The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of e...
journal_title:Gynecologic and obstetric investigation
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000343067
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:MIB 1 is a new monoclonal antibody which recognizes nuclei of proliferating cells throughout the cell cycle except during the G0 and early G1 phases. In the present study we analyzed the MIB 1 immunostaining as an index of cellular proliferation in cervical intraepithelial neoplasia (CIN) and microinvasive ca...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291977
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate maternal serum transformed alpha-fetoprotein (MSt-AFP) levels, a new molecular conformation of AFP was used in cases of threatened preterm labor (TPL). METHODS:Prospective case-control study. Maternal serum levels of classical AFP and transformed AFP (t-AFP) were compared between 2 groups m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000233239
更新日期:2009-01-01 00:00:00
abstract::In the present study we have measured the concentrations of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in preovulatory follicular fluid (FF) samples obtained from patients undergoing ovulation induction with human menopausal gonadotropin/human chorionic gonadotropin. In 13 of the 24 (54...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294853
更新日期:1992-01-01 00:00:00
abstract::We herein present a case of exencephaly with rachischisis, situs ambiguous and club feet, diagnosed antenatally by ultrasound. This combination of anomalies is very rare. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293305
更新日期:1990-01-01 00:00:00