Transformed alpha-fetoprotein (t-AFP) levels in women with threatened preterm labor.

Abstract:

BACKGROUND/AIMS:To evaluate maternal serum transformed alpha-fetoprotein (MSt-AFP) levels, a new molecular conformation of AFP was used in cases of threatened preterm labor (TPL). METHODS:Prospective case-control study. Maternal serum levels of classical AFP and transformed AFP (t-AFP) were compared between 2 groups matched by gestational age: 25 women with TPL and 25 healthy pregnant women as controls. RESULTS:There was no significant difference in classical maternal serum AFP (MSAFP) levels between the 2 groups. In contrast, MSt-AFP levels were significantly lower in cases of TPL than in the control group [7.64 (1.78-29.06) vs. 33.38 (13.80-190.50) ng/ml; p = 0.006]. Similarly, the t-AFP:AFP ratio was also decreased in the TPL group [0.04 (0.004-0.12) vs. 0.16 (0.05-0.80); p = 0.008]. There was no significant correlation between MSAFP and MSt-AFP levels. CONCLUSIONS:MSt-AFP levels are decreased in women with TPL.

journal_name

Gynecol Obstet Invest

authors

González-Bugatto F,Bailén Mde L,Fernández-Macías R,Fernández-Deudero A,Hervías-Vivancos B,Bartha JL

doi

10.1159/000233239

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

199-204

issue

3

eissn

0378-7346

issn

1423-002X

pii

000233239

journal_volume

68

pub_type

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