Effects of hormone replacement therapy on plasma homocysteine and C-reactive protein levels.

Abstract:

:In order to investigate the effect of hormone replacement therapy (HRT) on plasma homocysteine and C-reactive protein (CRP) levels 46 healthy postmenopausal women were prospectively enrolled. HRT, which was either 0.625 mg/day conjugated equine estrogen (CEE) plus 2.5 mg/day medroxyprogesterone acetate (MPA) or 0.625 mg/day CEE alone were administered. After 6 months, estrogen alone significantly increased serum CRP concentrations (p = 0.039), however, estrogen plus progesterone therapy did not significantly alter serum CRP levels. Both regimens significantly decreased plasma homocysteine levels (CEE group p = 0.034, CEE+MPA group p = 0.007). It was concluded that the reduction in plasma homocysteine levels with both regimens might contribute to the cardiovascular benefit of HRT and the CRP raising effect of estrogen might be partially prevented by the addition of progesterone.

journal_name

Gynecol Obstet Invest

authors

Yildirir A,Aybar F,Tokgozoglu L,Yarali H,Kabakci G,Bukulmez O,Sinici I,Oto A

doi

10.1159/000049412

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

54-8

issue

1

eissn

0378-7346

issn

1423-002X

pii

goi53054

journal_volume

53

pub_type

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