Involvement of phenotypes and serum levels of haptoglobin in the outcome of in vitro fertilization and embryo transfer.

Abstract:

:Haptoglobin (Hp) possesses many functions in the immune system and angiogenesis as well as scavenging released hemoglobin, and thus it is speculated that Hp may also play a critical role in the reproductive process. To investigate the possible involvement of Hp in the outcome of in vitro fertilization and embryo transfer (IVF-ET), the serum Hp of 50 patients who underwent IVF-ET was analyzed by the Western blot method. The results showed a higher pregnancy rate in the patients with the Hp2-2 phenotype (38%) than in those with the Hp2-1 phenotype (16%) (p = 0.08), and the serum alpha 2 subunit levels in the patients who achieved pregnancy within four attempts at IVF-ET were higher than in the others (p < 0.05). The results of this study suggest that Hp is involved in the outcome of IVF-ET.

journal_name

Gynecol Obstet Invest

authors

Ueda K,Yamamasu S,Nakamura Y,Honda K,Ozaki K,Fujino Y,Ishiko O,Ogita S

doi

10.1159/000058053

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

219-22

issue

4

eissn

0378-7346

issn

1423-002X

pii

58053

journal_volume

51

pub_type

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