Chromosome breakage in individuals with single-cell structural aberrations and habitual abortions.

Abstract:

:The rate of spontaneous and methotrexate (MTX)-induced chromosome breakage was studied in individuals with a history of habitual abortions in whom a structural chromosomal aberration was found in a single cell during routine cytogenetic analysis. Twelve such individuals were selected because they were not under the influence of any known mutagenic factor such as smoking, alcohol, medication and apparent irradiation; they were compared to 12 age- and sex-matched control parents. A detailed statistical analysis revealed that the spontaneous and MTX-induced chromosome breakage was significantly increased in the abortion group. The MTX-induced breakage rate was especially elevated in the women of the abortion group.

journal_name

Gynecol Obstet Invest

authors

Velissariou V,Lyberatou E,Antonopoulou E,Polymilis C

doi

10.1159/000292599

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

71-4

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

36

pub_type

杂志文章
  • Testicular feminization syndrome in the neonate.

    abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293367

    authors: van Zijl JA,Evers JL,Gerver WJ

    更新日期:1990-01-01 00:00:00

  • The influence of tocolytic therapy on serum digoxin-like immunoreactive substance concentration.

    abstract::Digoxin-like immunoreactive substance (DLIS) has been proposed to have a role in what seems to be the timely onset of labor. The relationship between the DLIS in patients with preterm labor and the success of tocolytic therapy with ritodrine and nifedipine has been studied. Using a commercially available radioimmunoas...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292511

    authors: Yapar EG,Ayhan A

    更新日期:1994-01-01 00:00:00

  • Mucin-like carcinoma-associated antigen serum levels in patients with adenocarcinomas originating from ovary, breast and colon.

    abstract::The mucin-like carcinoma-associated antigen (MCA) enzyme immunoassay was tested in 962 healthy controls. MCA levels were compared with CA 125 in 70 patients with benign and 76 with malignant ovarian tumors. In addition MCA was compared with CA 15.3 in 58 patients with breast cancer and with CEA in 50 patients with col...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291890

    authors: Bon GG,Verheijen RH,Zuetenhorst JM,van Kamp GJ,Verstraeten AA,Kenemans P

    更新日期:1996-01-01 00:00:00

  • Side effects of tamoxifen in oophorectomized rats.

    abstract:OBJECTIVE:Our objective was to evaluate the direct effect of tamoxifen citrate (TAM) on the endometrium, liver, breast tissue and the lipid profile in oophorectomized (OX) rats. STUDY DESIGN:An experimental animal study. MATERIAL AND METHODS:Forty-one mature rats (33 OX) were randomly divided into four groups and rec...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009933

    authors: Kafkasli A,Erdem F,Müezzinoglu B,Akbaşak B,Burak F,Aksoy T,Birincioglu M,Biotech MG,Biotec FT

    更新日期:1998-01-01 00:00:00

  • Cyclic changes in cervical microflora and their effect on infections following hysterectomy.

    abstract::In a prospective study the cyclic changes in the cervical microflora and the endometrial histology were correlated with the incidence of postoperative infections in 99 women undergoing elective abdominal hysterectomy. Escherichia coli and Bacteroides fragilis were isolated more frequently during the proliferative phas...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299447

    authors: Thadepalli H,Savage EW Jr,Salem FA,Roy I,Davidson EC Jr

    更新日期:1982-01-01 00:00:00

  • CD9 gene variations are not associated with female infertility in humans.

    abstract:BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphis...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000262451

    authors: Nishiyama S,Kishi T,Kato T,Suzuki M,Nishizawa H,Pryor-Koishi K,Sawada T,Nishiyama Y,Iwata N,Udagawa Y,Kurahashi H

    更新日期:2010-01-01 00:00:00

  • Effect of repeated doses of dexamethasone on the incidence and severity of respiratory distress syndrome in multifetal gestation between 24 and 34 weeks.

    abstract::The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052936

    authors: Al-Yatama MK,Al Essa M,Omu AE,Al-Shamali I,Egbase P,Rashwan N

    更新日期:2001-01-01 00:00:00

  • Effect of calcium and vitamin D supplementation on toxaemia of pregnancy.

    abstract::To study the effect of calcium and vitamin D supplementation on the incidence of toxaemia of pregnancy, 200 randomly selected pregnant women (supplemented group), were put on calcium (375 mg/day) and vitamin D (1,200 IU/day) supplements at 20-24 weeks of pregnancy onwards. Another 200 pregnant women constituted the no...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000298772

    authors: Marya RK,Rathee S,Manrow M

    更新日期:1987-01-01 00:00:00

  • Accelerated bone turnover in pregnant women with McCune-Albright syndrome.

    abstract::Bone turnover in pregnant women with McCune-Albright syndrome may be affected by both the syndrome and pregnancy. This study evaluated changes in biochemical bone turnover markers in pregnant women with the syndrome. Serum calcium, phosphorus, 1,25-dihydroxyvitamin D (1,25-(OH)2D), intact osteocalcin (I-OC) and alkali...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000085535

    authors: Osada H,Sakamoto R,Seki K,Sekiya S

    更新日期:2005-01-01 00:00:00

  • Prostacyclin does not influence placental blood pool in vivo.

    abstract::In 20 healthy pregnant women placental blood pool was estimated by means of placental scintigrams before, during and after infusion of either prostacyclin (PGI2) or placebo for 10 min to study the effect of PGI2 on the local regulation of uterine blood flow. There was no difference in the mean number of counts between...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000299012

    authors: Husslein P,Gitsch E,Pateisky N,Philipp K,Leodolter S,Sinzinger H

    更新日期:1985-01-01 00:00:00

  • Age distribution of erythrocyte population in women with twin pregnancy.

    abstract::An evaluation of the age distribution of erythrocytes in twin gestation was performed. Based on previous studies on age distribution of erythrocytes in late pregnancy, we have proposed that a more pronounced shift in age distribution of erythrocytes in twin pregnancy may be expected. We have used the density distribut...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292618

    authors: Lurie S,Blickstein I

    更新日期:1993-01-01 00:00:00

  • A Randomized Controlled Trial on Efficacy and Safety of Trocar-Site Infiltration with Lidocaine for Postoperative Pain Relief after Diagnostic Laparoscopy.

    abstract:BACKGROUND/AIMS:To compare the efficacy and safety of trocar-site infiltration with lidocaine and no intervention for postoperative pain relief after diagnostic laparoscopy. METHODS:A randomized clinical trial of women with infertility scheduled for diagnostic laparoscopy without additional procedures in Life Institut...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000490565

    authors: Joe-Ikechebelu NN,Eleje GU,Ugwu EO,Okafor CD,Nwachukwu CE,Okam PC,Ogboji OE,Ikechebelu JI

    更新日期:2019-01-01 00:00:00

  • Longitudinal measurement of amniotic fluid index in term pregnancies and its association with intrapartum fetal distress.

    abstract:OBJECTIVE:The aim of the present study was to evaluate the dynamic changes in serially obtained amniotic fluid index values and to determine any association with intrapartum fetal distress in a term population. MATERIALS AND METHODS:All patients, > or = 40 weeks of gestational age, evaluated at the Institute of Obstet...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000291535

    authors: Garzetti GG,Ciavattini A,La Marca N,De Cristofaro F

    更新日期:1997-01-01 00:00:00

  • Adrenoceptor function in female genital tract.

    abstract::The function of adrenoceptors in the female genital tract was tested estimating the uptake of 3H-noradrenaline (3H-NA) in vitro in oviductal, uterine arterial and myometrial tissue samples obtained from 74 women. The highest 3H-NA value, 64 +/- 5 ng/g, was in the oviduct (p less than 0.001 vs. uterine artery and myome...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293673

    authors: Saarikoski S

    更新日期:1988-01-01 00:00:00

  • Interval between port catheter flushing can be extended to four months.

    abstract:BACKGROUND:Little is known about proper interval periods between the flushings of totally implantable access ports after completion of chemotherapy. Manufacturer guidelines recommend flushing catheters every 4 weeks. METHODS:This retrospective study examined whether flushing less than every 4 weeks conferred any benef...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294919

    authors: Ignatov A,Ignatov T,Taran A,Smith B,Costa SD,Bischoff J

    更新日期:2010-01-01 00:00:00

  • Scanning electron microscopy of human Fallopian tube in ectopic pregnancy.

    abstract::The scanning electron microscopy by virtue of its high resolution topographic reproduction of epithelial surfaces lining the female genital tract, provides unique information toward understanding the anatomy and physiology of the female reproductive system. The human Fallopian ectopic pregnancy is an urgent gynecologi...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299226

    authors: Samberg I,Degani S,Zilberman A,Eibschitz I,Nir I,Scharf M

    更新日期:1983-01-01 00:00:00

  • Partial hydatidiform mole in the fallopian tube.

    abstract::An extremely rare case of partial hydatidiform mole located in the right Fallopian tube was diagnosed by ultrasonography and computed tomography. The lesion was excised, and the human chorionic gonadotropin (HCG) level in early morning urine fell below 1,000 IU/ml on postoperative day 11, and the serum HCG-beta level ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292708

    authors: Terada S,Suzuki N,Uchide K,Akasofu K

    更新日期:1993-01-01 00:00:00

  • Fetal kidney size related to gestational age.

    abstract::Fetal renal anatomy was assessed in 660 apparently normal fetuses. The problems of technique of visualization of the kidneys are outlined. A correlation of fetal kidney length and gestational age is presented. The results are presented to be used as an adjunct in establishing fetal gestational age, as well as the asse...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298825

    authors: Sagi J,Vagman I,David MP,Van Dongen LG,Goudie E,Butterworth A,Jacobson MJ

    更新日期:1987-01-01 00:00:00

  • Calcium dobesilate lowers the blood pressure in mild to moderate midtrimester hypertension: a pilot study.

    abstract::To test the effects of calcium dobesilate (Doxium) in pregnancies complicated with pregnancy-induced hypertension or mild/moderate pre-eclampsia a double-blind, placebo-controlled pilot study was carried out. Primigravida patients (gestational age

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000010080

    authors: Tamás P,Csermely T,Ertl T,Vizer M,Szabó I,Prievara FT

    更新日期:1999-01-01 00:00:00

  • Hypoxia represses the differentiation of Rcho-1 rat trophoblast giant cells.

    abstract:BACKGROUND:A hypoxic environment is known to be essential for early placentation. A low oxygen tension induces hypoxia-inducible factor-1 (HIF-1alpha) which may play an important role as a transcription factor in maintaining the proliferative and undifferentiated phenotype in human trophoblasts. METHODS:We analyzed th...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000097634

    authors: Takeda T,Sakata M,Isobe A,Yamamoto T,Nishimoto F,Minekawa R,Okamoto Y,Tasaka K,Murata Y

    更新日期:2007-01-01 00:00:00

  • Heart rate and blood pressure response and metabolic changes in the sheep fetus following reduction of uterine blood flow.

    abstract::The cardiovascular and metabolic responses during acute fetal hypoxia were studied in 7 pregnant sheep near term. Complete reduction of uterine flow (UBF) for 180 s was performed in 13 experiments by inflating a balloon positioned in the maternal aorta. Fetal heart rate (FHR), systolic and diastolic blood pressure (BP...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299425

    authors: Künzel W,Kastendieck E,Hohmann M

    更新日期:1983-01-01 00:00:00

  • Endogenous digoxin-like immunoreactivity in follicular fluid and in vitro fertilization.

    abstract::Plasma digoxin-like immunoreactive factor (DLIF) has been detected in various pathophysiological conditions associated with volume expansion. In this study, using radioimmunoassay, we confirmed the existence of high levels of DLIF in the stimulated follicular fluid, a rapidly volume-expanding biological model. The con...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293029

    authors: Jakobi P,Krivoy N,Eibschitz I,Ziskind G

    更新日期:1991-01-01 00:00:00

  • Cervical partial hydatidiform molar pregnancy.

    abstract:BACKGROUND:Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. CASE:We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on transvaginal ultrasound and color Do...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000141647

    authors: Aytan H,Caliskan AC,Demirturk F,Koseoglu RD,Acu B

    更新日期:2008-01-01 00:00:00

  • Proteoglycans from cultures of fibroblast from the human uterine cervix.

    abstract::A small dermatan sulphate proteoglycan has been isolated from the human uterine cervix. The concentration of this proteoglycan has been shown to decrease during pregnancy. To study the mechanism behind this change fibroblasts from the human uterine cervix were established in culture. Their synthesis and secretion of p...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299026

    authors: Uldbjerg N,Malmström A,Ekman G,Ulmsten U

    更新日期:1985-01-01 00:00:00

  • Clinical significance of squamous cell carcinoma antigen in cancer of the human uterine cervix. Comparison with CEA and CA-125.

    abstract::Serum squamous cell carcinoma antigen (SCCa) concentrations were determined by a radioimmunoassay kit before and during the treatment of 50 patients with cervical carcinoma: 44 with squamous cell carcinoma (SCC) and 6 with adenocarcinoma. The positivity rate of SCCa was 50% (52% for SCC and 33% for adenocarcinoma). Th...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292993

    authors: Verlooy H,Devos P,Janssens J,Mortelmans L,Gerits M,Bonte J,De Roo M

    更新日期:1991-01-01 00:00:00

  • Rheumatoid factor-associated high-molecular-weight complexes in the menstrual and amniotic fluids.

    abstract::We have previously described the identification of the human decidua-associated protein hDP200 as a rheumatoid factor [1]. Assuming that rheumatoid factor binds to Fc of immunoglobulins, the existence of high-molecular-weight complexes was studied in decidual extract, pooled uterine fluid from proliferative and early ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292272

    authors: Halperin R,Schneider D,Kraicer PF,Hadas E

    更新日期:1996-01-01 00:00:00

  • Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients.

    abstract:AIMS:To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. METHODS:A total of 96 patients undergoing IVF-ET were included in thi...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000162104

    authors: Choi YS,Kim SH,Ku SY,Jee BC,Suh CS,Choi YM,Kim JG,Moon SY

    更新日期:2009-01-01 00:00:00

  • Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders.

    abstract:BACKGROUND/AIMS:The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders. METHODS:A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000496609

    authors: Matsukawa S,Sumigama S,Kotani T,Wang J,Miki R,Moriyama Y,Nakano T,Mano Y,Tsuda H,Tamakoshi K,Kikkawa F

    更新日期:2019-01-01 00:00:00

  • Intrauterine balloon catheter for ultrasound evaluation of pelvic masses. Enhancement of uterus localization.

    abstract::Pelvic masses can be diagnosed by pelvic ultrasonography. Difficulties may be encountered to identify the organ origin of a pelvic mass. An intrauterine marker is proposed to facilitate the diagnosis by the exact localization of the uterus and its relationship to other pelvic findings. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298777

    authors: Zakut H,Achiron R

    更新日期:1987-01-01 00:00:00

  • Oligohydramnios, small for gestational age and pregnancy outcomes: an analysis using precise measures.

    abstract:BACKGROUND/AIM:Marginal or decreased amniotic fluid volume by ultrasound estimate and fetal growth restriction have been shown to be significantly associated with perinatal mortality. The association of fetal growth restriction and precisely measured amniotic fluid volume is unknown. The purpose of this study was to de...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000324570

    authors: Magann EF,Haas DM,Hill JB,Chauhan SP,Watson EM,Learman LA

    更新日期:2011-01-01 00:00:00