Effect of repeated doses of dexamethasone on the incidence and severity of respiratory distress syndrome in multifetal gestation between 24 and 34 weeks.

Abstract:

:The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies, who only had one course of dexamethasone, were compared with controls. Corticosteroid therapy was associated with a reduction in moderate to severe RDS in all groups (twins p < 0.01, triplets and quadruplets p < 0.008) and the emergency group with dexamethasone therapy (p < 0.036) when compared to their individual controls. Dexamethasone reduced the duration of stay in the neonatal intensive care unit of the emergency twin group (p < 0.01). Neonatal birth weights were significantly less in all groups treated with repeated doses in comparison to the controls.

journal_name

Gynecol Obstet Invest

authors

Al-Yatama MK,Al Essa M,Omu AE,Al-Shamali I,Egbase P,Rashwan N

doi

10.1159/000052936

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

26-33

issue

1

eissn

0378-7346

issn

1423-002X

pii

52936

journal_volume

52

pub_type

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