Human chorionic gonadotropin in cervicovaginal secretions as a predictor of preterm birth.

Abstract:

OBJECTIVE:To compare the qualitative (QL) and quantitative (QN) levels of betahCG in cervicovaginal secretions as predictors of preterm birth. METHODS:The study included 100 women. QL and QN assays were done with velocit kit and ELISA, respectively. RESULTS:A positive QL assay had sensitivity of 78%, specificity 95%, positive predictive value (PPV) 90%, negative predictive value (NPV) 88% and odds ratio (OR) = 70.87 (95% CI = 18.50, 271.50). The likelihood ratios (LRs) for positive and negative tests were 15.6 and 0.06, respectively. Using a cutoff value of 34.5 mIU/ml, the QN assay had sensitivity of 86%, specificity 86%, PPV 78% and NPV 92%, OR = 36.90 (95% CI = 10.79, 126.15). The LRs for positive and negative tests were 6.14 and 0.16, respectively. CONCLUSION:The simple and cheaper QL betahCG test is a better predictor of preterm birth as compared to the QN test.

journal_name

Gynecol Obstet Invest

authors

Rengaraj G,Guleria K,Suneja A,Gambhir JK

doi

10.1159/000189917

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

202-7

issue

3

eissn

0378-7346

issn

1423-002X

pii

000189917

journal_volume

67

pub_type

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