Abstract:
BACKGROUND/AIMS:The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders. METHODS:A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. Microarray analysis and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to extract upregulated genes in the adherent site. Gene expression changes were examined by immunohistochemistry. RESULTS:Microarray analysis showed that 157 transcripts were > 3-fold upregulated, including the following: a disintegrin and metalloproteinase-28 (ADAM28), 3.10-fold; cathepsin V (CTSV), 3.73-fold; cathepsin S (CTSS), 3.46-fold; and matrix metalloproteinase-19 (MMP19), 3.41-fold. RT-PCR showed relatively high mRNA expressions. On immunohistochemistry, extravillous trophoblast (EVT) at the non-adherent site showed weak or no CTSV expression, whereas EVT that invaded myometrium at the adherent site showed strong expression (histological score, median [min-max], 115.6 [37.6-153.6] vs. 184.8 [56.4-222.8], p < 0.05). MMP19 showed moderate staining, with no difference between the adherent and non-adherent sites. ADAM28 and CTSS showed weak or no staining. DISCUSSION:This limited study suggests that CTSV may be involved in the pathogenesis of PAS.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Matsukawa S,Sumigama S,Kotani T,Wang J,Miki R,Moriyama Y,Nakano T,Mano Y,Tsuda H,Tamakoshi K,Kikkawa Fdoi
10.1159/000496609subject
Has Abstractpub_date
2019-01-01 00:00:00pages
396-406issue
4eissn
0378-7346issn
1423-002Xpii
000496609journal_volume
84pub_type
杂志文章abstract::Cervico-oculo-acousticus syndrome is a very rare entity with only 21 cases described in the world literature. A study of a case of this syndrome with pregnancy is presented. This primigravida, in addition to the classical triad of the syndrome, had other dysmorphic features such as short stature (141 cm), and marked t...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293115
更新日期:1991-01-01 00:00:00
abstract::We experienced a typical case of eclampsia. After the onset of eclampsia, we performed magnetic resonance imaging angiography (MRI angiography) to estimate the function of the cerebral artery. MRI angiography showed that spasm occurred in many cerebral arteries. The spasm was still observed in some arteries 13 day aft...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292595
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abstract::The rate of spontaneous and methotrexate (MTX)-induced chromosome breakage was studied in individuals with a history of habitual abortions in whom a structural chromosomal aberration was found in a single cell during routine cytogenetic analysis. Twelve such individuals were selected because they were not under the in...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292599
更新日期:1993-01-01 00:00:00
abstract::Sixty postmenopausal women were randomly assigned to three types of treatment with intranasal salmon calcitonin (SCT) plus calcium 500 mg daily (group A: 100 IU daily of SCT; group B: 100 IU daily of SCT for alternate cycles of 2 months with a 1-month interval; group C: 100 IU daily of SCT for alternate cycles of 3 mo...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000294874
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous studies on the effects of estrogen on sclerostin regulation were conducted in postmenopausal women in humans or animals following estrogen treatment or induced estrogen deficiency. The aim of this study was to evaluate the effects of sex hormones on serum sclerostin levels in premenopausal wome...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000347013
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To study the association of umbilical cord presentation found on antenatal ultrasound and the incidence of cord prolapse in labor. STUDY DESIGN:We reviewed the antenatal records of all deliveries in the Mount Sinai Hospital in a 5-year period and conducted two separate retrospective studies. In the first stu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072323
更新日期:2003-01-01 00:00:00
abstract::Holtzman, female rats with a plastic or copper IUD were maintained on either a dexamethasone solution (9.4 or 28 micrograms/rat/day) in the drinking water or on water alone. Animals were caged with males of proven fertility and subsequently killed at day 14 of pregnancy and the number of implantation sites counted. Bo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299826
更新日期:1980-01-01 00:00:00
abstract::Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293608
更新日期:1989-01-01 00:00:00
abstract::In a prospective clinical investigation of 2,144 deliveries, we elucidate the indications for episiotomy and how different methods of anesthesia affect the frequency of episiotomy and the perineal problems after episiotomy compared with those after spontaneous perineal laceration. We found a significantly higher infec...
journal_title:Gynecologic and obstetric investigation
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doi:10.1159/000293161
更新日期:1991-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106489
更新日期:2007-01-01 00:00:00
abstract::The possible interaction of the newly developed triazole antifungal SCH 39304 with low-dose combined oral contraceptives (OCs) was studied in 15 healthy women. Serum levels of ovarian and adrenocortical steroids and sex hormone-binding globulin (SHBG) were analyzed in samples collected during the OC cycles immediately...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293003
更新日期:1991-01-01 00:00:00
abstract::To determine the relationship between abnormal fetal heart rate (FHR) patterns, fetal oxygen content by reflectance pulse oximetry, and the effects of maternal oxygen administration, 158 intrapartum women consisting of 120 women with normal FHR patterns, and 38 women with varying degrees of variable FHR decelerations ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291404
更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000093975
更新日期:2006-01-01 00:00:00
abstract::Corpus luteum activity was monitored in 15 women undergoing nonsurgical management of ectopic pregnancy with local methotrexate injection followed by alternating oral methotrexate and citrovorum factor (group A, n = 8) or local methotrexate injection alone (group B, n = 7). All patients initially demonstrated a viable...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294872
更新日期:1992-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000358389
更新日期:2014-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292710
更新日期:1993-01-01 00:00:00
abstract:AIMS:The study aimed to assess the diagnostic value of serial monitoring of biochemical inflammatory markers (C-reactive protein (CRP) and white blood cell (WBC) count) in the postoperative diagnosis of anastomotic leakage or ureteral injury after bowel resection for deep infiltrating endometriosis. METHODS:This is a ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000447513
更新日期:2017-01-01 00:00:00
abstract::Pelvic masses can be diagnosed by pelvic ultrasonography. Difficulties may be encountered to identify the organ origin of a pelvic mass. An intrauterine marker is proposed to facilitate the diagnosis by the exact localization of the uterus and its relationship to other pelvic findings. ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298777
更新日期:1987-01-01 00:00:00
abstract::Hyaluronan (HA), a high molecular weight polysaccharide, is a major component of connective tissue and is thus present in the extracellular matrix of most tissues. Increased serum concentrations have been reported in association with pre-eclampsia and liver malfunction, amongst other disorders. We have performed histo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052986
更新日期:2001-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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journal_title:Gynecologic and obstetric investigation
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更新日期:1996-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
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更新日期:1997-01-01 00:00:00
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journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:A hypoxic environment is known to be essential for early placentation. A low oxygen tension induces hypoxia-inducible factor-1 (HIF-1alpha) which may play an important role as a transcription factor in maintaining the proliferative and undifferentiated phenotype in human trophoblasts. METHODS:We analyzed th...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000097634
更新日期:2007-01-01 00:00:00
abstract:AIM:To evaluate the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL). METHODS:A prospective observational study with 154 pregnant women ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000480235
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:To assess the performance of colposcopists and correlate it with their experience when diagnosing cervical pathology by reviewing conventional colposcopy (CC) digital images and the Dynamic Spectral Imaging System (DySIS) cervical map. METHODS:Images from 50 women with normal and abnormal cervix collec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. METHODS:Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511440
更新日期:2020-12-04 00:00:00