Changes of beta-1,4-galactosyltransferase with the development of endometrial cancer.

Abstract:

:To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of beta-1,4-galactosyltransferase (beta-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that beta-1,4GT was diffusely positive in the cytoplasm of endometrial cancer cells, and that the level of its expression was increased compared with that in normal endometrium. Also, beta-1,4GT mRNA corresponding to 4.7 kb was very low in normal endometrium, while an intense signal was detected in endometrial cancer. Our results suggest that the increase of beta-1,4GT contributes to the expression of the type 2 carbohydrate chain in endometrial cancer.

journal_name

Gynecol Obstet Invest

authors

Kubushiro K,Ma J,Fukuchi T,Banno K,Muramatsu Y,Tsukazaki K,Nozawa S

doi

10.1159/000010158

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

211-4

issue

3

eissn

0378-7346

issn

1423-002X

pii

10158

journal_volume

48

pub_type

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