Effects of synthetic LH-RH and TRH on pituitary function in anencephalic infants.

Abstract:

:The pituitary endocrine function in 4 anencephalic infants was studied by measuring the concentrations of growth hormone, prolactin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in umbilical venous serum. There was no significant difference in hormone levels between the anencephalic and normal infants. The response of FSH and LH was negative after administration of 10 micrograms of luteinizing hormone-releasing hormone. The TSH levels after administration of 50 micrograms of TRH elevated about 4- to 6-fold over pre-administration levels. These results indicate that the hypothalamo-pituitary axis of the human fetus initiates its function from mid-pregnancy; TSH may have an autoregulating system of the pituitary itself.

journal_name

Gynecol Obstet Invest

authors

Furuhashi N,Suzuki M,Fukaya T,Kono H,Tachibana Y,Shinkawa O

doi

10.1159/000299842

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

231-6

issue

4

eissn

0378-7346

issn

1423-002X

journal_volume

11

pub_type

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