Abstract:
:The mucin-like carcinoma-associated antigen (MCA) enzyme immunoassay was tested in 962 healthy controls. MCA levels were compared with CA 125 in 70 patients with benign and 76 with malignant ovarian tumors. In addition MCA was compared with CA 15.3 in 58 patients with breast cancer and with CEA in 50 patients with colon carcinoma. In healthy controls the 95th percentile cutoff of 19.2 U/ml appeared to be higher than generally used. With the common cutoff value of 14 U/ml, a 38% sensitivity and 100% specificity was reached in malignant versus benign ovarian tumors. In colorectal cancer only 4% of patients had elevated MCA serum levels (CEA: 50%). In breast cancer patients the MCA assay performed better than CA 15.3 although only 17.2% showed elevated levels (CA 15.3: 7.4%). Thus MCA seems to be of limited value in the diagnosis and follow-up of adenocarcinomas of breast, ovary or colon.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Bon GG,Verheijen RH,Zuetenhorst JM,van Kamp GJ,Verstraeten AA,Kenemans Pdoi
10.1159/000291890subject
Has Abstractpub_date
1996-01-01 00:00:00pages
58-62issue
1eissn
0378-7346issn
1423-002Xjournal_volume
42pub_type
杂志文章abstract::Implantation of intrauterine devices (IUDs) is associated with an increased incidence of uterine infection, probably as a result of vaginal bacteria entering the uterus at the time of insertion. To reduce the incidence of IUD-related infections, the incorporation of antimicrobial agents into the tail of the device was...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010256
更新日期:2000-01-01 00:00:00
abstract::Two women, one 27 years old (case 1) and the other 20 years old (case 2), were evaluated due to right lower quadrant pain. The lactate dehydrogenase level was increased in case 1 and the dihydroepiandostrone level was increased in both cases. Preoperative transvaginal ultrasonography revealed solid masses, but the tum...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000053009
更新日期:2002-01-01 00:00:00
abstract::Holtzman, female rats with a plastic or copper IUD were maintained on either a dexamethasone solution (9.4 or 28 micrograms/rat/day) in the drinking water or on water alone. Animals were caged with males of proven fertility and subsequently killed at day 14 of pregnancy and the number of implantation sites counted. Bo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299826
更新日期:1980-01-01 00:00:00
abstract::In 121 women attending the infertility clinic between 1978 and 1982, 127 cycles with luteal phases of 10 days or more were investigated by a complete basal body temperature (BBT) chart, three plasma progesterone assays taken between 11 and 4 days before menses, and a dated endometrial biopsy (EB) taken at the time of ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299140
更新日期:1984-01-01 00:00:00
abstract::Alternations of the pelvic structure with an emphasis on those of the levator ani muscle, associated with uterine prolapse, were studied using sagittal magnetic resonance images obtained from 19 subjects without and 14 with uterine or vaginal prolapse of varied degree and 3 patients with Rokitansky syndrome who had un...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292723
更新日期:1992-01-01 00:00:00
abstract::We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation i...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000052877
更新日期:2000-01-01 00:00:00
abstract::Amniotic fluids from women in West Virginia were evaluated for the presence of antibacterial activity by a bioassay technique. 41% of 32 third trimester samples were inhibitory. Evaluation of additional test organisms emphasized differences in susceptibility of various bacterial strains; two isolates of Escherichia co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299390
更新日期:1983-01-01 00:00:00
abstract:AIMS:To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. METHODS:A total of 96 patients undergoing IVF-ET were included in thi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000162104
更新日期:2009-01-01 00:00:00
abstract::The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052936
更新日期:2001-01-01 00:00:00
abstract::This study was undertaken to evaluate the response to parenteral administration of iron in 62 pregnant patients with asiderotic anemia and mean initial hemoglobin (Hb) concentrations (Hb1) of 9.91+/-(SD) 1.13 g/dl. Iron (742+/-366 mg) was administered intravenously, and the response to treatment was classified accordi...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010109
更新日期:1999-01-01 00:00:00
abstract::Fertility-sparing surgery (FSS) is an established concept within operative gynaecology. Intraoperative ultrasound (IOUS) has the potential of assessing lesion margins, allowing complete resection with minimal damage to the surrounding healthy tissue and could potentially play a major role in FSS for benign or malignan...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000505689
更新日期:2020-01-01 00:00:00
abstract::Maternofetal transfer of ritodrine and its effect on placental glucose and oxygen consumption were studied using a recycling perfusion of maternal and fetal circulations of an isolated cotyledon of a term human placenta. 3H-labeled ritodrine was introduced into the maternal side of the perfusion system. Transfer was c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292983
更新日期:1991-01-01 00:00:00
abstract::In a prospective clinical investigation of 2,144 deliveries, we elucidate the indications for episiotomy and how different methods of anesthesia affect the frequency of episiotomy and the perineal problems after episiotomy compared with those after spontaneous perineal laceration. We found a significantly higher infec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293161
更新日期:1991-01-01 00:00:00
abstract::To evaluate a new reflectance photometer (Accusport) for blood lactate determination, a prospective non-interventional study was performed on blood obtained from the umbilical cord artery immediately after delivery of the baby in 109 consecutive women. For each sample, the results of cord arterial blood lactate values...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009919
更新日期:1998-01-01 00:00:00
abstract::Highly evacuated (980 mbar) wound drainage systems according to Redon were used in 100 gynecologic laparotomies. In 96% of cases, no flask exchange was required before the system was removed. Bacteriological specimens from various locations of the Redon system showed minimal colonization with pathogenic bacteria. No c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293758
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To study the association of umbilical cord presentation found on antenatal ultrasound and the incidence of cord prolapse in labor. STUDY DESIGN:We reviewed the antenatal records of all deliveries in the Mount Sinai Hospital in a 5-year period and conducted two separate retrospective studies. In the first stu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072323
更新日期:2003-01-01 00:00:00
abstract::We report the third case of a prenatal diagnosis of Larsen's syndrome, which is the first report affecting both a 37-year-old primiparous caucasian woman and her fetus not considered to have Larsen's syndrome until the finding of bilateral clubfeet was demonstrated on screening ultrasound at 23 weeks of gestation. His...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010050
更新日期:1998-01-01 00:00:00
abstract::The relative roles of the cyclic nucleotide messengers cAMP and cGMP in the suppression of follicle-stimulating hormone (FSH) secretion in response to inhibin (IBN) were assessed employing rat gonadotropes in monolayer culture. While exposure of cells to gonadotropin-releasing hormone (GnRH) induced a significant incr...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298808
更新日期:1987-01-01 00:00:00
abstract::Circulating levels of leptin, estradiol (E(2)) and progesterone (P(4)) throughout normal menstrual cycles (n = 13), and controlled, stimulated cycles (n = 33) were examined using sensitive specific radioimmunoassays in order to investigate the relationships between sex hormones (E(2), P(4)). Serum leptin levels during...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010228
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000106489
更新日期:2007-01-01 00:00:00
abstract::In a prospective study the cyclic changes in the cervical microflora and the endometrial histology were correlated with the incidence of postoperative infections in 99 women undergoing elective abdominal hysterectomy. Escherichia coli and Bacteroides fragilis were isolated more frequently during the proliferative phas...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299447
更新日期:1982-01-01 00:00:00
abstract::The rate of spontaneous and methotrexate (MTX)-induced chromosome breakage was studied in individuals with a history of habitual abortions in whom a structural chromosomal aberration was found in a single cell during routine cytogenetic analysis. Twelve such individuals were selected because they were not under the in...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292599
更新日期:1993-01-01 00:00:00
abstract::Sonography has achieved a position of preeminence in the diagnostic evaluation of molar gestation. However, little information is available about the serial change of the transvaginal sonographic features of molar pregnancy. We describe a case of complete hydatidiform mole, and present serial transvaginal views taken ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072082
更新日期:2003-01-01 00:00:00
abstract::To determine the placental clearance of lactate and bicarbonate in sheep, the fetal side of an isolated cotyledon and the umbilical circulation of the total placenta were artificially perfused. The release and uptake of lactate and bicarbonate by the perfusion fluid and the fetomaternal concentration differences of th...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299913
更新日期:1979-01-01 00:00:00
abstract::Adenoma malignum (minimum deviation adenocarcinoma) is a rare neoplasma of the uterine cervix, the diagnosis of wich cannot be determined by cervical smear. Recently, magnetic resonance imaging (MRI) was reported as useful for its diagnosis, but differentiation of adenoma malignum from deep-seated nabothian cysts rema...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009959
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate the dynamic changes in serially obtained amniotic fluid index values and to determine any association with intrapartum fetal distress in a term population. MATERIALS AND METHODS:All patients, > or = 40 weeks of gestational age, evaluated at the Institute of Obstet...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291535
更新日期:1997-01-01 00:00:00
abstract::25 singleton pregnancies were terminated by cesarean section between 28 and 33 weeks of gestation because of suspected growth retardation and abnormal unstressed cardiotocograms. Only infants with birth weights below the tenth centile were considered. 17 survived and were neurologically examined at 2.5-7 years of age....
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299030
更新日期:1985-01-01 00:00:00
abstract::A solitary peritoneal metastasis from a poorly differentiated adenocarcinoma of unknown origin in a 38-year-old female is described. The patient presented with a left ovarian tumor and elevated cancer antigen 125. She underwent complete excision of tumor and received six courses of postoperatively adjuvant cisplatin-b...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291858
更新日期:1997-01-01 00:00:00
abstract::Fifty-six patients with pelvic endometriosis were treated with a buserelin dosage of 200 micrograms/day s.c. for 6 months. Scoring of the American Fertility Society (AFS) for endometriosis was performed by laparoscopy in all cases before and at the end of therapy. Serum CA-125 and estradiol levels were determined befo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292491
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to investigate the in vivo magnetic resonance spectroscopy features of uterine leiomyomas using long echo time and to characterize the spectral patterns of these lesions. METHODS:We calculated metabolites in 15 patients with uterine leiomyomas and myometrium of 20 healthy control...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000080020
更新日期:2004-01-01 00:00:00