Common genetic changes between endometriosis and ovarian cancer.

Abstract:

:We analyzed 81 ovarian cancers for loss of heterozygosity (LOH) on 10q23 and for mutations in PTEN. LOH was common among the endometrioid (43%) and serous (28%) cancers, but was infrequent among the other histological subtypes. Somatic PTEN mutations were detected in seven (21%) endometrioid cancers and the mutation in all informative cases was accompanied by loss of the wild-type allele. One mucinous cancer without 10q23 LOH was shown to harbor two somatic PTEN mutations. Frequent LOH was observed on chromosome 6q (60.0%) and chromosome 10q (40.0%) in ovarian atypical endometriosis, but no PTEN mutations were observed. These findings support the hypothesis that endometrioid and clear cell ovarian carcinomas may arise through malignant transformation of endometriotic lesions.

journal_name

Gynecol Obstet Invest

authors

Obata K,Hoshiai H

doi

10.1159/000052877

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

39-43

eissn

0378-7346

issn

1423-002X

pii

52877

journal_volume

50 Suppl 1

pub_type

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