Transplacental transfer of ritodrine and its effect on placental glucose and oxygen consumption in an in vitro human placental cotyledon perfusion.

Abstract:

:Maternofetal transfer of ritodrine and its effect on placental glucose and oxygen consumption were studied using a recycling perfusion of maternal and fetal circulations of an isolated cotyledon of a term human placenta. 3H-labeled ritodrine was introduced into the maternal side of the perfusion system. Transfer was calculated from the linear rise of ritodrine concentrations on the fetal side and was found to be 7.31 +/- 1.02 ng/g placental wet weight/min (SEM) when 1.4 micrograms/ml of ritodrine was used (n = 3) and 14.7 +/- 1.06 ng/g placental wet weight/min when the concentration was 2.8 micrograms/ml (n = 5). The antipyrine transfer rate, 4.1 +/- 0.51 mg/kg/min (n = 8), was used to demonstrate perfusion adequacy and served as an internal standard. Upon computing the mass balance of ritodrine and antipyrine at the end of the experiment, it was found that 17% of ritodrine disappeared from the perfusion system compared to 0.7% of antipyrine (p less than 0.01). The introduction of ritodrine into the perfusion system did not affect placental glucose and oxygen consumption rates of 0.35 +/- 0.01 mumol/g/min (n = 7) and 0.19 +/- 0.013 mumol/g/min (n = 5), respectively.

journal_name

Gynecol Obstet Invest

authors

Urbach J,Mor L,Fuchs S,Brandes JM

doi

10.1159/000292983

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

10-4

issue

1

eissn

0378-7346

issn

1423-002X

journal_volume

32

pub_type

杂志文章
  • Etiology of serum CA-125 in patients with endometriosis treated with a gonadotrophin-releasing hormone agonist (Buserelin).

    abstract::Fifty-six patients with pelvic endometriosis were treated with a buserelin dosage of 200 micrograms/day s.c. for 6 months. Scoring of the American Fertility Society (AFS) for endometriosis was performed by laparoscopy in all cases before and at the end of therapy. Serum CA-125 and estradiol levels were determined befo...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292491

    authors: Cetin T,Vardar MA,Demir C,Burgut R

    更新日期:1994-01-01 00:00:00

  • Primary omental pregnancy presenting with hemorrhagic shock. A case report.

    abstract::Abdominal pregnancy is a very rare and serious type of extrauterine gestation that accounts for approximately 0.003% of all ectopic pregnancies. Omental pregnancy, an extremely rare form of abdominal pregnancy, can be primary or secondary to a tubal pregnancy that aborts out of the fimbria and reimplants in the perito...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000070188

    authors: Ozdemir I,Demirci F,Yucel O,Alper M

    更新日期:2003-01-01 00:00:00

  • Maternal blood distribution of zinc and copper during labor and after delivery.

    abstract::In 15 normal mothers the stress effects of labor on zinc and copper distributions in erythrocytes and plasma were investigated. Lower levels of total zinc and of zinc derived from both carbonic anhydrase isoenzymes (CA-I and CA-II), especially from CA-I, in erythrocytes were obtained immediately after delivery. On the...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298798

    authors: Yamashita K,Ohno H,Kondo T,Kawamura M,Mure K,Yorozu Y,Ishikawa M,Shimizu T,Taniguchi N

    更新日期:1987-01-01 00:00:00

  • Placental alkaline phosphatase compared with human placental lactogen and oestriol in high-risk pregnancies.

    abstract::Serum levels of placental alkaline phosphatase (PLAP), human placental lactogen (HPL) and oestriol (E3) were investigated in 33 women with high-risk pregnancies. In pregnancies complicated by intrauterine growth retardation (IUGR) low PLAP values were constantly recorded. HPL values showed a similar pattern while E3 l...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299082

    authors: Ronin-Walknowska E,Holmgren PA,von Schoultz B,Stigbrand T

    更新日期:1984-01-01 00:00:00

  • A clinicohysteroscopic scoring system of intrauterine adhesions.

    abstract::We propose a new scoring system for intrauterine adhesions (IUA) that may predict the prognosis after hysteroscopic adhesiolysis. We analyzed hysteroscopic findings and clinical data of patients diagnosed as having IUA by reviewing previously published hysteroscopic classifications of IUA. The data were subjected to e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010305

    authors: Nasr AL,Al-Inany HG,Thabet SM,Aboulghar M

    更新日期:2000-01-01 00:00:00

  • Conservative treatment of ectopic pregnancy and its effect on corpus luteum activity.

    abstract::Corpus luteum activity was monitored in 15 women undergoing nonsurgical management of ectopic pregnancy with local methotrexate injection followed by alternating oral methotrexate and citrovorum factor (group A, n = 8) or local methotrexate injection alone (group B, n = 7). All patients initially demonstrated a viable...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294872

    authors: Shulman A,Maymon R,Zmira N,Lotan M,Holtzinger M,Bahary C

    更新日期:1992-01-01 00:00:00

  • Preeclampsia and maternal heart rate variability.

    abstract::Maternal heart rate variability was evaluated by means of 24-hour Holter ECG monitoring in three groups of patients (15 preeclamptic, 15 women hospitalized due to other complications and 15 normal ambulatory pregnant women) in the 28th-33rd week of gestation. Heart rate variability was estimated by time and frequency ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009949

    authors: Eneroth E,Storck N

    更新日期:1998-01-01 00:00:00

  • Mixed clear cell and endometrioid carcinoma arising in parietal endometriosis.

    abstract:AIM:We report a case of a mixed clear cell and endometrioid carcinoma arising in parietal endometriosis. METHODS:A 46-year-old woman presented a second recurrence of parietal endometriosis. An extensive surgical resection of the tumor was then carried out. RESULTS:Histological analysis revealed heterogeneous tissues ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000096437

    authors: Razzouk K,Roman H,Chanavaz-Lacheray I,Scotté M,Verspyck E,Marpeau L

    更新日期:2007-01-01 00:00:00

  • Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum.

    abstract:OBJECTIVE:To investigate the incidence of glucose intolerance postpartum in women with gestational diabetes (GDM) and assess body weight, cholesterol and triglyceride concentrations after delivery. METHODS:This was a study of an initial cohort of 100 women with GDM who were tested at 6 weeks, 6 months, and 1 year post...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000331652

    authors: Saucedo R,Zarate A,Basurto L,Hernandez M,Puello E,Campos S,Moreno E

    更新日期:2012-01-01 00:00:00

  • Diagnostic aid of endometrium biopsy.

    abstract::The 784 cases, from which 701 complained of abnormal uterine bleeding, were reviewed by age groups, presenting symptoms, sex steroid medication and endometrial findings. Endometrial polyps and endometritis, which showed an incidence of 17.5 and 10.0%, respectively, were correlated with clinicopathologic findings. Peri...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299980

    authors: van Bogaert LJ

    更新日期:1979-01-01 00:00:00

  • Tension-free vaginal tape procedure: an effective minimally invasive operation for the treatment of recurrent stress urinary incontinence?

    abstract::The aim of this study was to evaluate the results of tension-free vaginal tape (TVT) surgery in women with recurrent stress urinary incontinence (SUI). Fifty-one women with recurrent SUI were treated with TVT and followed prospectively for a minimum of 2 years according to a protocol. Twenty percent of the women had a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072942

    authors: Kuuva N,Nilsson CG

    更新日期:2003-01-01 00:00:00

  • Hysterectomy and lower urinary tract symptoms: a nonrandomized comparison of vaginal and abdominal hysterectomy.

    abstract:BACKGROUND/AIMS:It has been reported that lower urinary tract symptoms (LUTS) are more prevalent in patients who have undergone hysterectomy. However, the effects of surgical approach of hysterectomy on micturition have not been well documented. The aim of this study is to compare LUTS between patients who underwent va...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000297507

    authors: Lakeman MM,van der Vaart CH,Roovers JP,HysVA study group.

    更新日期:2010-01-01 00:00:00

  • Pathophysiology and possible iatrogenic cause of leiomyomatosis peritonealis disseminata.

    abstract::We present a case of leiomyomatosis peritonealis disseminata (LPD) after myoma morcellation and review the literature using the keywords leiomyomatosis peritonealis disseminata and disseminated peritoneal leiomyomatosis. The search was conducted in Medline, EMBASE, and Cochrane Database of systematic reviews. We encou...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000274487

    authors: Al-Talib A,Tulandi T

    更新日期:2010-01-01 00:00:00

  • Acute effect of dihydralazine on uteroplacental blood flow in hypertension during pregnancy.

    abstract::The uteroplacental blood flow was measured in 12 women with hypertension during pregnancy before and after intravenous injection of dihydralazine. After intravenous administration of 18.5 MBq (0.5 mCi) 113mIn, the gamma radiation emanating from the placenta was recorded with a computer-linked gamma camera during 10-se...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299279

    authors: Lunell NO,Lewander R,Nylund L,Sarby B,Thornström S

    更新日期:1983-01-01 00:00:00

  • Human papillomavirus DNA in triple neoplasms of the cervix, perianus and ureter in one woman.

    abstract:BACKGROUND:Multiple malignancies of the urogenital tract have been reported. We investigated the etiological role of human papillomavirus (HPV) in the pathogenesis of urogenital cancers. CASE:We present a case of cervical squamous carcinoma in a 64-year-old woman who subsequently developed Bowen's disease in the peria...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000097139

    authors: Huang LW,Pan HS,Lin YH,Chou KY

    更新日期:2007-01-01 00:00:00

  • Effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human myometrium.

    abstract::The effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human isthmic myometrium was examined. Methergin (10(-8)-10(-6) g/ml) enhanced plateau potential and contraction, however, the effects were not prominent. Plateau potential and contraction were also potentiated afte...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293327

    authors: Kawarabayashi T,Kishikawa T,Sugimori H

    更新日期:1990-01-01 00:00:00

  • Laparoscopic ovarian cystectomy versus fenestration/coagulation or laser vaporization for the treatment of endometriomas: a meta-analysis of randomized controlled trials.

    abstract:AIM:To compare outcomes after laparoscopic ovarian cystectomy versus fenestration/coagulation or laser ablation for the treatment of endometriomas. METHODS:Studies were identified by searching the PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trials databases using the terms ovarian, endometrioma...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,meta分析

    doi:10.1159/000351165

    authors: Dan H,Limin F

    更新日期:2013-01-01 00:00:00

  • Maternal endothelin-1 and cyclic guanosine monophosphate concentrations in pregnancies complicated by pregravid and gestational diabetes mellitus.

    abstract:BACKGROUND/AIMS:Pregnancy complicated by diabetes is associated with increased risk of unfavorable obstetric outcomes. A common abnormality in diabetes is endothelial dysfunction resulting in an altered pattern of vasoactive substance production by the endothelial cells. The aim of study was to assess serum endothelin-...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000253851

    authors: Swiderski S,Celewicz Z,Miazgowski T,Ogonowski J

    更新日期:2010-01-01 00:00:00

  • Estrogen-producing ovarian adenocarcinoma with large abscess formation.

    abstract::We report a postmenopausal patient with serous papillary cystadenocarcinoma of the ovary associated with large abscess formation and estrogen production. Ovarian cancer accompanied by stromal function is an occasional event, but large abscess association is a rarity. The present case is thus even rarer. Her clinical c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292710

    authors: Yoshida M,Katsuragawa H,Miyamoto U,Ohnishi S,Katsura Y

    更新日期:1993-01-01 00:00:00

  • Accuracy of frozen section diagnosis in borderline ovarian malignancy.

    abstract::This study was conducted to determine the accuracy of frozen section diagnosis in borderline ovarian tumors. Thirty-three patients were evaluated on the basis of frozen sections between February 1992 and December 1997. Frozen section diagnosis and final diagnosis were divided into three categories: for frozen section ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010244

    authors: Kayikçioglu F,Pata O,Cengiz S,Tulunay G,Boran N,Yalvaç S,Köse MF

    更新日期:2000-01-01 00:00:00

  • The Importance of Mid-Follicular Phase Luteinizing Hormone Rise in GnRH Antagonist-Based Ovarian Stimulation for IVF.

    abstract:INTRODUCTION:Previous publications examined the endocrinology of follicular stimulation, focusing on luteinizing hormone (LH) levels changes. In selected, good prognosis IVF patients, a sharp drop in LH serum level was demonstrated between cycle days 2 and 6. OBJECTIVE:The purpose of this study was to examine if this ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000505688

    authors: Vanetik S,Beck-Fruchter R,Segal L,Kol S

    更新日期:2020-01-01 00:00:00

  • Prenatal diagnosis and obstetric management of Larsen's syndrome in a patient with an unrecognized family history of the disease.

    abstract::We report the third case of a prenatal diagnosis of Larsen's syndrome, which is the first report affecting both a 37-year-old primiparous caucasian woman and her fetus not considered to have Larsen's syndrome until the finding of bilateral clubfeet was demonstrated on screening ultrasound at 23 weeks of gestation. His...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010050

    authors: Dören M,Rehder H,Holzgreve W

    更新日期:1998-01-01 00:00:00

  • Effect of an aromatase inhibitor in human follicular fluid on DNA synthesis of granulosa cells, theca cells, and follicles.

    abstract::An aromatase inhibitor was identified in human follicular fluid. We sought to examine the effects of this inhibitor on granulosa cells, theca cells, a mixture of granulosa and theca cells, and follicles. Granulosa cells, theca cells, the mixture of granulosa and theca cells, and follicles were incubated with [3H]-thym...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292692

    authors: Ono T,Komiya Y,Kawagoe SN,Hiroi M

    更新日期:1993-01-01 00:00:00

  • Elevated Expression of T-Cell Immunoglobulin and Mucin Domain 3 on T Cells from Peripheral Blood in Patients with Cervical Carcinoma.

    abstract:OBJECTIVE:To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. METHODS:Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were co...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000511440

    authors: Li J,Sun XF,Shen Y,Yang Q,Dai SY

    更新日期:2020-12-04 00:00:00

  • Can a low-lying placenta be the risk factor of cervical incompetence? A preliminary study on the relationship between placenta insertion and anatomical status of uterine cervix.

    abstract::An attempt was made to verify the hypothesis that a low-lying placenta may be a factor leading to the dynamic form of cervical incompetence. A vaginal evaluation of the cervix was made in 143 pregnant women who by means of ultrasonographic method were found to have low-lying placentas. In as many as 68 out of the 143 ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298964

    authors: Uszyński M,Majczyński T,Uszyński W

    更新日期:1985-01-01 00:00:00

  • Is radical hysterectomy necessary in early cervical cancer?

    abstract:AIMS:To estimate the prevalence of tumor spread to the parametrium, vagina and uterine corpus in radical hysterectomy specimens and define a subgroup of patients with low-risk of extracervical involvement, who may benefit from less radical surgery. METHODS:We retrospectively reviewed 96 patients with stage IA1-IIA cer...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000353899

    authors: Meirovitz M,Sade S,Dreiher J,Shaco-Levy R

    更新日期:2013-01-01 00:00:00

  • Reference values for resistance index and pulsatility index of uteroplacental Doppler flow velocity waveforms based on 612 uneventful pregnancies.

    abstract::Using a 4-MHz continuous-wave Doppler device, standard rates were established for resistance index (RI) and pulsatility index (PI) of uterine and arcuate arteries of 612 patients with uneventful pregnancies and deliveries. From 18 to 41 weeks of gestation, neither RI nor PI of uterine or arcuate arteries proved to var...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292732

    authors: Grab D,Hütter W,Sterzik K,Terinde R

    更新日期:1992-01-01 00:00:00

  • Clinical significance of squamous cell carcinoma antigen in cancer of the human uterine cervix. Comparison with CEA and CA-125.

    abstract::Serum squamous cell carcinoma antigen (SCCa) concentrations were determined by a radioimmunoassay kit before and during the treatment of 50 patients with cervical carcinoma: 44 with squamous cell carcinoma (SCC) and 6 with adenocarcinoma. The positivity rate of SCCa was 50% (52% for SCC and 33% for adenocarcinoma). Th...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292993

    authors: Verlooy H,Devos P,Janssens J,Mortelmans L,Gerits M,Bonte J,De Roo M

    更新日期:1991-01-01 00:00:00

  • Antenatal diagnosis of congenital heart disease and fetal arrhythmia by ultrasound: prospective study.

    abstract::Fetal echocardiographic and Doppler ultrasonographic prospective studies were performed in utero on 299 babies delivered at Hirata Municipal Hospital, Shimane, Japan, from May 1984 to June 1986. Two or three ultrasonographic examinations were performed on each fetus from 20 weeks of gestation to term. Three congenital...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293682

    authors: Hata T,Takamori H,Hata K,Takamiya O,Murao F,Kitao M

    更新日期:1988-01-01 00:00:00

  • Elevated immunoreactivity against class I histone deacetylases in adenomyosis.

    abstract:BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000336409

    authors: Liu X,Nie J,Guo SW

    更新日期:2012-01-01 00:00:00