Effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human myometrium.

Abstract:

:The effect of methylergometrine maleate (methergin) on electrical and mechanical activities of pregnant human isthmic myometrium was examined. Methergin (10(-8)-10(-6) g/ml) enhanced plateau potential and contraction, however, the effects were not prominent. Plateau potential and contraction were also potentiated after pretreatment with 10(-7) g/ml phentolamine (alpha-blocker), however 10(-7) g/ml methergin further increased these effects. It is suggested that methergin might potentiate contractions by changing the pattern of action potentials and not by alpha-adrenoceptor.

journal_name

Gynecol Obstet Invest

authors

Kawarabayashi T,Kishikawa T,Sugimori H

doi

10.1159/000293327

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

246-9

issue

4

eissn

0378-7346

issn

1423-002X

journal_volume

29

pub_type

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