Comparison of Serum A Disintegrin and Metalloproteinase with Thrombospondin Motifs-19 Levels in Different Fertility Situations: Could It Be a Serum Marker of Ovarian Function and Oocyte Pool?

Abstract:

BACKGROUND/AIMS:A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes take part in extracellular matrix (ECM) remodeling which has been shown to contribute to the ovulation and follicular functions. We aimed to compare serum levels of ADAMTS-19 in patients with different fertility situations. METHODS:A total of 86 women were enrolled to this cross sectional and case-control study. Four groups were constituted with respect to women's clinical and hormonal status: group 1, women with premature ovarian failure (POF; n = 21); group 2, women with natural menopause (n = 21); group 3, women with polycystic ovary syndrome (PCOS; n = 22); and group 4, healthy fertile controls. Serum ADAMTS-19 levels and individual characteristics were compared among groups. RESULTS:-ADAMTS-19 levels were found as 36.7 ± 10.2, 40.1 ± 12.6, 46.7 ± 16.1, and 51.0 ± 18.8 ng/mL in POF, fertile, natural menopause, and PCOS groups, respectively (p = 0.012). Especially, ADAMTS-19 levels in the PCOS group were significantly higher than the POF group, as found in dual comparisons (p = 0.010). CONCLUSIONS:ADAMTS-19 was found to be higher in PCOS patients than in POF patients. This work provides a novel vantage point for function of ECM within the ovary. ADAMTS-19 may have a potential for being an important marker of ovarian function and oocyte pool.

journal_name

Gynecol Obstet Invest

authors

Ersoy E,Özler S,Öztaş E,Ersoy AÖ,Ergin M,Tokmak A,Yilmaz N

doi

10.1159/000490665

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

6-11

issue

1

eissn

0378-7346

issn

1423-002X

pii

000490665

journal_volume

84

pub_type

杂志文章
  • Unexpected nature of a pelvic mass in pregnancy: Castleman's disease.

    abstract::The obstetrician is rarely confronted with a pregnant patient who presents with a large suspicious pelvic mass. Diagnostic tools are not always of value and laparotomy may be performed for obstetric and histopathologic reasons. In this article we present an interesting case of an unusual pelvic mass in pregnancy secon...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293507

    authors: Başer I,Dilek S,Pabuçcu R,Ulgenalp I,Mermut S,Finci R

    更新日期:1989-01-01 00:00:00

  • Persistence of Lactobacilli in Postmenopausal Women - A Double-Blind, Randomized, Pilot Study.

    abstract:AIM:To investigate the ability of lactobacilli to persist in the genital area (vagina and labia) of women after the topical application of an ointment containing Lactobacillus gasseri LN40, L. fermentum LN99 and L. rhamnosus LN113. Secondary objectives were to study the presence of Escherichia coli and other contaminan...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000446946

    authors: Kwak YK,Daroczy K,Colque P,Kühn I,Möllby R,Kopp Kallner H

    更新日期:2017-01-01 00:00:00

  • Insulin-like growth factor 1 receptor mRNA expression and autophosphorylation in human myometrium and leiomyoma.

    abstract::Uterine leiomyomas are the most common tumors of the genital tract. Growth factors seem to be implicated in the development of leiomyoma. The aim of this study was to determine insulin-like growth factor 1 receptor (IGF-1-R) mRNA levels and IGF-1-R tyrosine kinase activity in normal myometrium and leiomyoma. Plasma me...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000076690

    authors: Martin Chaves EB,Brum IS,Stoll J,Capp E,Corleta Hv

    更新日期:2004-01-01 00:00:00

  • Serial transvaginal sonography of a case of complete hydatidiform mole.

    abstract::Sonography has achieved a position of preeminence in the diagnostic evaluation of molar gestation. However, little information is available about the serial change of the transvaginal sonographic features of molar pregnancy. We describe a case of complete hydatidiform mole, and present serial transvaginal views taken ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072082

    authors: Shioji M,Shimoya K,Koyama M,Kanzaki T,Murata Y

    更新日期:2003-01-01 00:00:00

  • Immunohistological study in cases of HELLP syndrome (hemolysis, elevated liver enzymes and low platelets) and acute fatty liver of pregnancy.

    abstract::We immunohistologically studied the hepatic tissue sections in cases with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome; n = 2) and acute fatty liver of pregnancy (AFLP; n = 2) compared to necropsy controls. Unlike in the AFLP cases, a marked infiltration of neutrophils in liver ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292053

    authors: Halim A,Kanayama N,El Maradny E,Maehara K,Takahashi A,Nosaka K,Fukuo S,Amamiya A,Kobayashi T,Terao T

    更新日期:1996-01-01 00:00:00

  • Clinical effects of preoperative oestradiol treatment before vaginal repair operation. A double-blind, randomized trial.

    abstract::The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000292320

    authors: Mikkelsen AL,Felding C,Clausen HV

    更新日期:1995-01-01 00:00:00

  • Effects of add-back therapy on bone mineral density and pyridinium crosslinks in patients with endometriosis treated with gonadotropin-releasing hormone agonists.

    abstract::Treatment of endometriosis with gonadotropin-releasing hormone agonists (GnRHa) is limited to 6 months because of possible adverse effects on bone metabolism. We designed a randomized, double-blind, placebo-controlled, prospective study of 27 patients with endometriosis who were given GnRHa with or without hormone add...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000010059

    authors: Gnoth CH,Gödtke K,Freundl G,Godehardt E,Kienle E

    更新日期:1999-01-01 00:00:00

  • A statistical approach to the determination of the fertile period.

    abstract::17 beta-Estradiol (E2), basal body temperature (BBT) and luteinizing hormone (LH), were measured in normally menstruating women. The preovulatory E2 observations were characterized by variations about a constant level during the preovula-peak. The BBT observations typically varied about a constant level during the pre...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299523

    authors: Carter RL,Abrams RM,Moghissi KS

    更新日期:1982-01-01 00:00:00

  • Accuracy of frozen section diagnosis in borderline ovarian malignancy.

    abstract::This study was conducted to determine the accuracy of frozen section diagnosis in borderline ovarian tumors. Thirty-three patients were evaluated on the basis of frozen sections between February 1992 and December 1997. Frozen section diagnosis and final diagnosis were divided into three categories: for frozen section ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010244

    authors: Kayikçioglu F,Pata O,Cengiz S,Tulunay G,Boran N,Yalvaç S,Köse MF

    更新日期:2000-01-01 00:00:00

  • Intravenous iron therapy in pregnancy anemia: hematological response in relation to gestational age.

    abstract::This study was undertaken to evaluate the response to parenteral administration of iron in 62 pregnant patients with asiderotic anemia and mean initial hemoglobin (Hb) concentrations (Hb1) of 9.91+/-(SD) 1.13 g/dl. Iron (742+/-366 mg) was administered intravenously, and the response to treatment was classified accordi...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000010109

    authors: Carretti N,Paticchio MR

    更新日期:1999-01-01 00:00:00

  • Correlating the accuracy of colposcopy with practitioner experience when diagnosing cervical pathology using the dynamic spectral imaging system.

    abstract:BACKGROUND/AIMS:To assess the performance of colposcopists and correlate it with their experience when diagnosing cervical pathology by reviewing conventional colposcopy (CC) digital images and the Dynamic Spectral Imaging System (DySIS) cervical map. METHODS:Images from 50 women with normal and abnormal cervix collec...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000365087

    authors: Coronado PJ,Fasero M

    更新日期:2014-01-01 00:00:00

  • Vaginal cuff closure: a comparison between the vaginal route and laparoscopic suture in patients undergoing total laparoscopic hysterectomy.

    abstract:BACKGROUND:To compare the vaginal route and laparoscopic suture for vaginal cuff closure (VCC) in patients undergoing a total laparoscopic hysterectomy (TLH). METHODS:A total of 471 women who required hysterectomy were allocated to two groups. 261 women had TLH via VCC by the vaginal route and 210 women had TLH via VC...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000316052

    authors: Hwang JH,Lee JK,Lee NW,Lee KW

    更新日期:2011-01-01 00:00:00

  • Human chorionic gonadotropin in cervicovaginal secretions as a predictor of preterm birth.

    abstract:OBJECTIVE:To compare the qualitative (QL) and quantitative (QN) levels of betahCG in cervicovaginal secretions as predictors of preterm birth. METHODS:The study included 100 women. QL and QN assays were done with velocit kit and ELISA, respectively. RESULTS:A positive QL assay had sensitivity of 78%, specificity 95%,...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000189917

    authors: Rengaraj G,Guleria K,Suneja A,Gambhir JK

    更新日期:2009-01-01 00:00:00

  • Lymphokine-activated killer activity in women with endometriosis.

    abstract::The aim of the present study was to investigate whether women with endometriosis displayed a decreased lymphokine-activated killer (LAK) activity. In 15 women with and 7 women without endometriosis the cytotoxicity against four different tumor cell lines--K562, the endometrium carcinomas AN3CA and RL95, the natural-ki...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292556

    authors: Oosterlynck DJ,Lacquet FA,Waer M,Koninckx PR

    更新日期:1994-01-01 00:00:00

  • Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

    abstract:BACKGROUND:Pentraxin 3 (PTX3) is a novel vascular inflammatory marker which increases in vascular events such as diabetes mellitus. The aim of this study was to investigate the relationship between serum PTX3 levels and gestational diabetes mellitus (GDM). METHODS:This prospective observational study was comprised of ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000373889

    authors: Yildirim M,Simavli SA,Uysal Derbent A,Kaygusuz I,Uysal S

    更新日期:2015-01-01 00:00:00

  • Expression of the Peptidase "Fibroblast Activation Protein" on Decidual Stromal Cells Facilitating Tissue Remodeling.

    abstract:INTRODUCTION:Expression of fibroblast activation protein (FAP) has been detected in activated fibroblasts participating in injury response, fibrotic and inflammatory conditions, and tumorigenesis. Human endometrium is equally characterized by rapid tissue remodeling events due to the reproductive tasks comprising the a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000511439

    authors: Segerer SE,Bartmann C,Schwab M,Kämmerer U

    更新日期:2020-01-01 00:00:00

  • Should we continue performing intrauterine inseminations in the year 2004?

    abstract::This review summarizes the existing evidence regarding intrauterine insemination (IUI) as a treatment for cervical hostility, male and unexplained subfertility. IUI in natural cycles has been proven effective in patients with cervical hostility and moderate male subfertility. IUI in cycles with mild ovarian hyperstimu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000080492

    authors: Cohlen BJ

    更新日期:2005-01-01 00:00:00

  • Surgical treatment of tuberculous paraparesis in the third trimester: a report of two cases and review of the literature.

    abstract:BACKGROUND:Tuberculous paraplegia as a consequence of spinal infiltration in pregnancy is reported to be rare. Analysis of the current literature produces few case studies that report successful outcomes. Delay in diagnosis and treatment may ultimately result in an irreversible neurological deficit. The potential impli...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000235869

    authors: Loughenbury P,Pavlou G,Dunsmuir R

    更新日期:2009-01-01 00:00:00

  • Nasal bone measurement during the 1st trimester: is it useful?

    abstract::The aim of this study was to present our preliminary data about nasal bone measurements at 11-14 weeks of pregnancy. This study was conducted in our prenatal unit between 2000 and 2003. A total of 642 pregnant women (single pregnancies) were enrolled into the study. During the first trimester of pregnancy, crown-rump ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000078499

    authors: Kelekci S,Yazicioğlu HF,Oguz S,Inan I,Yilmaz B,Sönmez S

    更新日期:2004-01-01 00:00:00

  • Blood loss during transvaginal oocyte retrieval.

    abstract:BACKGROUND/AIMS:Limited information is available regarding the quantity of blood loss associated with uncomplicated transvaginal oocyte retrieval. The aim of the present study was evaluating the quantity of such a loss. METHODS:One hundred and fifty consecutive women undergoing oocyte retrieval were recruited. They un...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000158649

    authors: Ragni G,Scarduelli C,Calanna G,Santi G,Benaglia L,Somigliana E

    更新日期:2009-01-01 00:00:00

  • Plasma fibronectin receptor levels during pregnancy complicated by preeclampsia and abruptio placentae.

    abstract::The level of human fibronectin receptor (FNR) in plasma was measured by enzyme-linked immunosorbent assay in samples from normal pregnant women in the 1st trimester (n = 5), 2nd trimester (n = 7), 3rd trimester (n = 23), normal postpartum women day 1 (n = 4), day 2 (n = 5), day 3 (n = 8), nonpregnant women (n = 18), 2...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000294869

    authors: Kanayama N,Terao T

    更新日期:1992-01-01 00:00:00

  • Can women's cognitive appraisals be registered throughout childbirth?

    abstract::The aims of the present study were: (a) to examine whether it was possible to measure women's cognitive appraisals hourly during the whole process of labor and delivery, and (b) to explore how the appraisals varied during labor. Measurements from 12 nulliparous women are presented. The findings indicate that it is pos...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010209

    authors: Alehagen S,Wijma K,Wijma B

    更新日期:2000-01-01 00:00:00

  • Can labor with breech presentation be induced?

    abstract::Our objective was to evaluate the efficacy and safety of labor induction in women with a breech presentation, and an unripe cervix. We conducted a retrospective, matched-paired study on patients with breech presentation and an unripe cervix (n = 23), who underwent induction of labor using extra-amniotic saline instill...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010029

    authors: Fait G,Daniel Y,Lessing JB,Bar-Am A,Gull I,Shenhav M,Kupferminc MJ

    更新日期:1998-01-01 00:00:00

  • Testicular feminization syndrome in the neonate.

    abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293367

    authors: van Zijl JA,Evers JL,Gerver WJ

    更新日期:1990-01-01 00:00:00

  • Immunosuppressant material in human seminal fluid. Inhibition of blast transformation and of NK activity by seminal fluid patients of a male infertility clinic.

    abstract::Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK activity. Using the test of inhibition of NK activity, the semen samples from individuals with higher c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298834

    authors: Marcus ZH,Lunenfeld B,Weissenberg R,Lewin LM

    更新日期:1987-01-01 00:00:00

  • Conventional and computerized antepartum telecardiotocography. Experienced and inexperienced observers versus computerized analysis.

    abstract::The study assessed the agreement in cardiotocogram interpretation between the 2CTG computerized system and experienced and inexperienced observers involved in a telecardiotocography project called 'TOCOMAT'. Both observers and computer analyzed FHR baseline, FHR variability, and number of large accelerations and of de...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000068955

    authors: Di Lieto A,Giani U,Campanile M,De Falco M,Scaramellino M,Papa R

    更新日期:2003-01-01 00:00:00

  • Vulvar papillomatosis, aceto-white lesions, and normal-looking vulvar mucosa evaluated by microscopy and human papillomavirus analysis.

    abstract:BACKGROUND AND OBJECTIVES:To assess the presence of human papillomavirus (HPV) DNA in vulvar papillomatosis, since some women with this complaint have symptoms associated with HPV infection, such as itching, burning, and dyspareunia. GOAL:To reassure the patients that they do not have a transmissible viral disease, by...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292350

    authors: Strand A,Wilander E,Zehbe I,Kraaz W,Rylander E

    更新日期:1995-01-01 00:00:00

  • Study of uterine prolapse by magnetic resonance imaging: topographical changes involving the levator ani muscle and the vagina.

    abstract::Alternations of the pelvic structure with an emphasis on those of the levator ani muscle, associated with uterine prolapse, were studied using sagittal magnetic resonance images obtained from 19 subjects without and 14 with uterine or vaginal prolapse of varied degree and 3 patients with Rokitansky syndrome who had un...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292723

    authors: Ozasa H,Mori T,Togashi K

    更新日期:1992-01-01 00:00:00

  • Ovarian morphology in patients with polycystic ovaries and in an age-matched reference material. A statistical evaluation of 149 cases.

    abstract::The ovarian morphology in 149 patients with the clinical syndrome of polycystic ovaries (group I) is described. The ovaries from 10 age-matched women (group II) with no signs of ovarian disorder were investigated as a reference material. The number of cysts documented for group I was twice that of the reference group ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293771

    authors: Lunde O,Hoel PS,Sandvik L

    更新日期:1988-01-01 00:00:00

  • Osseous Metaplasia and Subsequent Spontaneous Pregnancy Chance: A Case Report and Review of the Literature.

    abstract:BACKGROUNDS:What is not clear as yet is not only the etiology, but also the management of osseous metaplasia. We describe an infertile patient with osseous metaplasia and subsequent pregnancy after treatment and review the literature from infertility perspective. METHOD:We presented a 30-year-old woman with 8 years of...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000439529

    authors: Bozdag G,Mumusoglu S,Dogan S,Esinler I,Gunalp S

    更新日期:2015-01-01 00:00:00