Abstract:
OBJECTIVE:Our objective was to evaluate the direct effect of tamoxifen citrate (TAM) on the endometrium, liver, breast tissue and the lipid profile in oophorectomized (OX) rats. STUDY DESIGN:An experimental animal study. MATERIAL AND METHODS:Forty-one mature rats (33 OX) were randomly divided into four groups and received either TAM (0.4 or 0.8 mg/kg p.o.) therapy or placebo over 60 days as follows: (1) sham; (2) OX + TAM (0.4 mg/kg); (3) OX + TAM (0.8 mg/kg); (4) OX. All histological changes in the endometrium, liver and breast tissue were evaluated under the light microscope by comparing the TAM-treated groups with the OX and sham-operated groups. Blood total cholesterol and low-density lipoprotein cholesterol levels were also analyzed. RESULTS:TAM-treated rats showed a significant reduction in body weight, blood cholesterol and low-density lipoprotein cholesterol levels, but the wet uterine weight was not affected. Estrogenic effects of TAM were not detected with either dosage on the endometrium. TAM-treated groups showed atrophic breast tissue. No histopathological changes were detected in the liver with TAM treatment. CONCLUSION:The data suggests that TAM may not act as an estrogen receptor agonist with the given dosage on the endometrium in OX rats. Two different doses of TAM do not cause histological changes in liver over 60 days of treatment.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Kafkasli A,Erdem F,Müezzinoglu B,Akbaşak B,Burak F,Aksoy T,Birincioglu M,Biotech MG,Biotec FTdoi
10.1159/000009933subject
Has Abstractpub_date
1998-01-01 00:00:00pages
93-8issue
2eissn
0378-7346issn
1423-002Xpii
goi45093journal_volume
45pub_type
杂志文章abstract::To evaluate both the incidence of c-myc gene mutation and the relationship of this finding to the clinico-pathologic characteristics of patients with cervical cancer, a polymerase chain reaction (PCR)-based heteroduplex gel electrophoresis method was used to screen DNA extracted from 102 cervical invasive carcinomas r...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291505
更新日期:1997-01-01 00:00:00
abstract:AIM:The aim of the study was to compare the effectiveness of dienogest (DIE), depo medroxyprogesterone 17-acetate (MPA), and micronized progesteron (MP) regimens for treatment of simple endometrial hyperplasia (EH) without atypia. METHODS:One hundred and twenty premenopausal patients aged between 35 and 55, with simpl...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000477618
更新日期:2018-01-01 00:00:00
abstract::In 8 fetal sheep under anesthesia, we examined the relationship between the fetal aorta blood flow velocity waveform and fetal mean arterial pressure after administration of norepinephrine and angiotensin II. It was hypothesized that the pulsatility index (PI) of the waveform would change during fetal hypertension. Me...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292583
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Human placentae from normal and pre-eclamptic pregnancies were evaluated for possible changes in gene expression by microarray analysis to uncover new clues for the research of the etiology of pre-eclampsia. METHODS:Placentae from five normal pregnancies and five pregnancies complicated by pre-eclampsia were...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092857
更新日期:2006-01-01 00:00:00
abstract::The effects of estradiol-17 beta (E2) and clomiphene citrate (CC) on pituitary-uterine function in ovariectomized (OVX) rats were compared in two experiments. In experiment 1, CC completely blocked E2 stimulation of uterine weight when administered concurrently for 10 and 30 days. In experiment 2, content of total (oc...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293095
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:The endometriosis fertility index (EFI) is a novel index for predicting pregnancy after surgery. We investigated the utility of the EFI for predicting the ability to conceive without assisted reproductive technology (ART) treatment after laparoscopic surgery. METHODS:From July 2011 through December 2012, we ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000480454
更新日期:2018-01-01 00:00:00
abstract::Connective tissue of human ovarian capsule with polycystic ovarian disease (PCO) is analyzed. The connective tissue components of the capsule were found to mainly consist of type I collagen and acid glycosaminoglycans, such as dermatan sulfate, heparan sulfate, and chondroitin 4- and 6-sulfate. Although their concentr...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299089
更新日期:1984-01-01 00:00:00
abstract::Endometriosis is a sex steroids-dependent disease. It has been postulated that certain genetic polymorphisms involved in sex steroids biosynthesis and metabolisms may be associated with increased risk of developing endometriosis. Despite a deluge of reports of positive associations of endometriosis with numerous polym...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000089011
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Dyslipidemia is commonly observed in polycystic ovary syndrome (PCOS) patients. Bezafibrate is a drug for dyslipidemia acting through peroxisome proliferator-activated receptors. We investigated the effects of bezafibrate for ovulation induction in patients with PCOS with dyslipidemia who were resistant to c...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000316265
更新日期:2010-01-01 00:00:00
abstract::Two women, one 27 years old (case 1) and the other 20 years old (case 2), were evaluated due to right lower quadrant pain. The lactate dehydrogenase level was increased in case 1 and the dihydroepiandostrone level was increased in both cases. Preoperative transvaginal ultrasonography revealed solid masses, but the tum...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000053009
更新日期:2002-01-01 00:00:00
abstract::Serum levels of placental alkaline phosphatase (PLAP), human placental lactogen (HPL) and oestriol (E3) were investigated in 33 women with high-risk pregnancies. In pregnancies complicated by intrauterine growth retardation (IUGR) low PLAP values were constantly recorded. HPL values showed a similar pattern while E3 l...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299082
更新日期:1984-01-01 00:00:00
abstract::The scanning electron microscopy by virtue of its high resolution topographic reproduction of epithelial surfaces lining the female genital tract, provides unique information toward understanding the anatomy and physiology of the female reproductive system. The human Fallopian ectopic pregnancy is an urgent gynecologi...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299226
更新日期:1983-01-01 00:00:00
abstract::A suburethral sling procedure using a Mersilene mesh has been performed in 24 patients. Six patients had recurrent incontinence after an unsuccessful past operation. A postoperative follow-up was done for an average of 24 months. Twenty-three patients were free of symptoms, while only 1 patient had recurrent incontine...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292521
更新日期:1994-01-01 00:00:00
abstract::This study was conducted in order to investigate the usefulness of granulocyte elastase levels as predictive factors in the onset of perinatal infections. The subjects were 41 patients who delivered within 48 h after amniocentesis after giving their informed consent. The relationship between cervical granulocyte elast...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292401
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:Some embryo implantation problems in patients with recurrent implantation failure may be explained by the inability of the embryo to hatch out of its zona pellucida. In this case-control study, a study group which had received modified quarter laser-assisted zona thinning (mQLAZT) was compared with a co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000171068
更新日期:2009-01-01 00:00:00
abstract::The pathophysiology of postpartum urinary retention (PUR) is still unclear. The prevalence rate varies with the definition used and the literature discusses various risk factors. Bladder catheterization is the treatment of choice, but the best way to do it is not ascertained. Long-term sequelae seem to be rare. There ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000099306
更新日期:2007-01-01 00:00:00
abstract::The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied. Serum reproductive hormone concentrations, clinical findings and ovarian morphology were analyzed in 71 WWE who had been receiving antiepileptic drugs (AED) for a minimum of 2 years. Of the 71 WW...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000203537
更新日期:2009-01-01 00:00:00
abstract::The concentration of P29, a phosphoprotein related to estradiol receptor (RE), was measured by an immunoradiometric assay in human breast cancer cytosol and the results compared with the levels of RE and progesterone receptors (RP), as measured by the classical ligand-binding assay. Good linear correlation was found b...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293689
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To clarify the alteration of maternal-fetal mixed lymphocyte reaction (MLR) in intrahepatic cholestasis of pregnancy (ICP). METHODS:Twenty-two patients with intrahepatic cholestasis of pregnancy and 21 normal pregnant women were recruited into the present study. Of patients with ICP, 5 also experienced pregn...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000068381
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. METHODS:We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphis...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000262451
更新日期:2010-01-01 00:00:00
abstract:AIMS:To document progress with human papillomavirus (HPV) vaccine introduction in three closely related European countries, one with organized (the Netherlands) and two with opportunistic cervical cancer screening (Belgium and Luxembourg). METHODS:Experts involved in cervical cancer screening and national immunization...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000314010
更新日期:2010-01-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might al...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000072694
更新日期:2003-01-01 00:00:00
abstract::Semistructured interviews were made among a random sample of applicants for abortion in Stockholm, when legal abortion on demand had been available in Sweden for 10 years. One hundred and twenty women were interviewed, 75 of them having their first abortion and 45 having a repeat abortion. The use of contraceptives wa...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292572
更新日期:1994-01-01 00:00:00
abstract::A defect in placental function has been suggested to be associated both with preeclampsia (PE), with or without concomitant intrauterine growth retardation (IUGR), and with IUGR as a single entity. Our aim was to compare the mRNA expression of the growth-related protooncogenes c-fos and c-jun and the vasoconstrictor a...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291494
更新日期:1997-01-01 00:00:00
abstract::A solitary peritoneal metastasis from a poorly differentiated adenocarcinoma of unknown origin in a 38-year-old female is described. The patient presented with a left ovarian tumor and elevated cancer antigen 125. She underwent complete excision of tumor and received six courses of postoperatively adjuvant cisplatin-b...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291858
更新日期:1997-01-01 00:00:00
abstract:AIMS:The study aimed to compare the clinical course and disease severity between culture positive and culture negative patients with intra-uterine devices (IUD)-associated pelvic inflammatory disease (PID). METHODS:A retrospective study of all IUD-associated PID patients admitted to tertiary medical center between 201...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000490666
更新日期:2019-01-01 00:00:00
abstract::The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all informati...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000478982
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIM:We aimed to assess the value of early laparoscopic therapy in management of tubo-ovarian abscess (TOA) or pelvic abscess. METHODS:This was a retrospective study of all consecutive patients who were initially diagnosed with TOA or pelvic abscess at the local hospital between January 2010 and December 201...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000493855
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To perform a health economics analysis of 5 screening programs for osteoporosis in perimenopausal Thai women comparing two alternatives; without intervention and universal treatment without screening. DESIGN:A decision analysis was performed to evaluate five screening strategies: Dual energy X-ray absorptiom...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092803
更新日期:2006-01-01 00:00:00
abstract::The feasibility of performing hysteroscopic endomyometrial resection using isotonic 2.2% glycine as distension medium was studied in 181 consecutive operations. A standard continuous flow loop-resectoscope was used. Distension was achieved by means of a gravity-fed system and glycine flowed out under its own pressure....
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010119
更新日期:1999-01-01 00:00:00