Higher Levels of Triglyceride, Fatty Acid Translocase, and Toll-Like Receptor 4 and Lower Level of HDL-C in Pregnant Women with GDM and Their Close Correlation with Neonatal Weight.

Abstract:

OBJECTIVES:In this study, we aimed to compare the levels of maternal blood lipids, placental and venous blood lipid transporters, and inflammatory factor receptors in pregnant women with and without gestational diabetes mellitus (GDM). We also aimed to figure out the relationship between these values and neonatal weight. METHODS:Fifty pregnant women with GDM under blood glucose control belong to the case group, and 50 pregnant women with normal glucose tolerance in concurrent delivery belong to the control group. Fasting venous blood of these pregnant women was taken 2 weeks before delivery, and umbilical cord blood was collected after delivery. The levels of triglyceride (TG), serum total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) in maternal blood and umbilical cord blood were tested in the laboratory department of our hospital. The level of toll-like receptor 4 (TLR4) in serum of umbilical veins was detected by the double-antibody sandwich ELISA. Western blot and RT-PCR were used to detect the protein and mRNA expressions of TLR4, LPL, and FAT/CD36 in the placenta. RESULTS:The level of TG in maternal blood in the case group was remarkably higher than that in the control group, which was opposite to the level of HDL-C. In the umbilical cord blood of women with GDM, the expression of TLR4 increased and was closely correlated with neonatal weight. In the placenta of women with GDM, the expressions of FAT/CD36 and TLR4 increased, and both of them were closely correlated with neonatal weight. Besides, TLR4 in umbilical cord blood increased and was closely correlated with neonatal weight. Although the expression of LPL in the placenta decreased, it had no obvious correlation with neonatal weight. CONCLUSIONS:TG in maternal blood, TLR4 in the placenta and umbilical cord blood, and FAT/CD36 in the placenta were positively correlated with neonatal weight. However, HDL-C in maternal blood was negatively correlated with neonatal weight. Although the expression of LPL in the placenta reduced due to GDM, it had no correlation with neonatal weight.

journal_name

Gynecol Obstet Invest

authors

Zhou J,Bai J,Guo Y,Fu L,Xing J

doi

10.1159/000510032

subject

Has Abstract

pub_date

2021-01-22 00:00:00

pages

1-7

eissn

0378-7346

issn

1423-002X

pii

000510032

pub_type

杂志文章
  • Cyclic changes in cervical microflora and their effect on infections following hysterectomy.

    abstract::In a prospective study the cyclic changes in the cervical microflora and the endometrial histology were correlated with the incidence of postoperative infections in 99 women undergoing elective abdominal hysterectomy. Escherichia coli and Bacteroides fragilis were isolated more frequently during the proliferative phas...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299447

    authors: Thadepalli H,Savage EW Jr,Salem FA,Roy I,Davidson EC Jr

    更新日期:1982-01-01 00:00:00

  • Prenatal diagnosis of minute supernumerary marker chromosomes.

    abstract::The identification of supernumerary marker chromosomes (SMC) at prenatal diagnosis is problematic, particularly for the prediction of phenotype. The assessment of phenotypic risk is based on the size, morphology and origin of the SMC. Fluorescence in situ hybridization (FISH) characterization and family studies are al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000083482

    authors: Cotter PD,Drexler K,Corley AL,Covert SM,Moland JS,Govberg IJ,Norton ME

    更新日期:2005-01-01 00:00:00

  • Primary omental pregnancy presenting with hemorrhagic shock. A case report.

    abstract::Abdominal pregnancy is a very rare and serious type of extrauterine gestation that accounts for approximately 0.003% of all ectopic pregnancies. Omental pregnancy, an extremely rare form of abdominal pregnancy, can be primary or secondary to a tubal pregnancy that aborts out of the fimbria and reimplants in the perito...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000070188

    authors: Ozdemir I,Demirci F,Yucel O,Alper M

    更新日期:2003-01-01 00:00:00

  • Maternal free thyroxine and thyroxine-binding globulin during pregnancy ending in congenital malformations in the offspring.

    abstract::Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293608

    authors: Skjöldebrand Sparre LS

    更新日期:1989-01-01 00:00:00

  • Is the incidence of urinary bladder endometriosis increasing? Figures from Finland.

    abstract:OBJECTIVE:Urinary bladder endometriosis is a severe form of endometriosis often requiring surgery. The several cases treated at our hospital in recent years has led us to evaluate the incidence of urinary bladder endometriosis in Finland. METHODS:We performed a register-based analysis of incidence of urinary bladder e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000288161

    authors: Vaarala MH,Hellstrom P,Santala M

    更新日期:2010-01-01 00:00:00

  • Termination of pregnancy in a woman with hereditary antithrombin deficiency under antithrombotic protection with subcutaneous heparin and infusion of plasma.

    abstract::Subcutaneous heparin and plasma infusion were successfully used during an induced abortion in a young woman with familial antithrombin-III deficiency and a history of severe thrombotic episodes. :Women with herditary antithrombin-3 deficiency are exposed to a considerable risk of thrombosis during periods of thrombog...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299612

    authors: Jespersen J

    更新日期:1981-01-01 00:00:00

  • Benefit of GnRH analogue pretreatment for hysteroscopic surgery in patients with bleeding disorders.

    abstract::Hysteroscopic surgery is widely used for the treatment of patients suffering from menorrhagia. In different studies, pretreatment of the endometrium with GnRH analogues (GnRH-a) prior to endometrial ablation has been reported to increase the success rate, as well as to reduce the menstrual blood flow, accounting for a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000052847

    authors: Römer T

    更新日期:1998-01-01 00:00:00

  • Magnetic resonance imaging angiography in a case of eclampsia.

    abstract::We experienced a typical case of eclampsia. After the onset of eclampsia, we performed magnetic resonance imaging angiography (MRI angiography) to estimate the function of the cerebral artery. MRI angiography showed that spasm occurred in many cerebral arteries. The spasm was still observed in some arteries 13 day aft...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292595

    authors: Kanayama N,Nakajima A,Maehara K,Halim A,Kajiwara Y,Isoda H,Masui T,Terao T

    更新日期:1993-01-01 00:00:00

  • A clinicohysteroscopic scoring system of intrauterine adhesions.

    abstract::We propose a new scoring system for intrauterine adhesions (IUA) that may predict the prognosis after hysteroscopic adhesiolysis. We analyzed hysteroscopic findings and clinical data of patients diagnosed as having IUA by reviewing previously published hysteroscopic classifications of IUA. The data were subjected to e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010305

    authors: Nasr AL,Al-Inany HG,Thabet SM,Aboulghar M

    更新日期:2000-01-01 00:00:00

  • Prostacyclin does not influence placental blood pool in vivo.

    abstract::In 20 healthy pregnant women placental blood pool was estimated by means of placental scintigrams before, during and after infusion of either prostacyclin (PGI2) or placebo for 10 min to study the effect of PGI2 on the local regulation of uterine blood flow. There was no difference in the mean number of counts between...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000299012

    authors: Husslein P,Gitsch E,Pateisky N,Philipp K,Leodolter S,Sinzinger H

    更新日期:1985-01-01 00:00:00

  • A phase II study of weekly docetaxel for patients with advanced or recurrent cancer of the cervix.

    abstract:BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000106489

    authors: Pearl ML,Johnston CM,McMeekin DS

    更新日期:2007-01-01 00:00:00

  • Uteroplacental blood flow measurement using radioisotopes in small placentas.

    abstract::In 25 pregnant females with a placental weight below the 20th percentile uteroplacental blood flow measurements using 113mIn-transferrin were performed in the 3rd trimester of pregnancy. Twelve patients with pregnancy-induced hypertension (PIH) were compared to 13 females with normal blood pressures. The results of ut...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298931

    authors: Philipp K,Skodler WD,Pateisky N

    更新日期:1986-01-01 00:00:00

  • Relationship between granulocyte elastase levels and perinatal infections.

    abstract::This study was conducted in order to investigate the usefulness of granulocyte elastase levels as predictive factors in the onset of perinatal infections. The subjects were 41 patients who delivered within 48 h after amniocentesis after giving their informed consent. The relationship between cervical granulocyte elast...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292401

    authors: Matsuda Y,Maruyama H,Kuraya K

    更新日期:1995-01-01 00:00:00

  • Cervico-oculo-acousticus syndrome with pregnancy.

    abstract::Cervico-oculo-acousticus syndrome is a very rare entity with only 21 cases described in the world literature. A study of a case of this syndrome with pregnancy is presented. This primigravida, in addition to the classical triad of the syndrome, had other dysmorphic features such as short stature (141 cm), and marked t...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293115

    authors: Sholapurkar SL,Dhall GI

    更新日期:1991-01-01 00:00:00

  • Effects of caffeine ingestion during pregnancy.

    abstract::We studied the effects of caffeine ingestion during pregnancy. A total number of 9,921 healthy pregnant women with a gestational age after 24 weeks were subjected to the study. The women who drank more than 5 cups of coffee per day had a high incidence of impending abortion, premature labor, and fetuses small for gest...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299032

    authors: Furuhashi N,Sato S,Suzuki M,Hiruta M,Tanaka M,Takahashi T

    更新日期:1985-01-01 00:00:00

  • Early development of HELLP syndrome: a case report.

    abstract::The HELLP syndrome is a severe complication of pregnancy. It usually occurs in the middle of the third trimester. In our case, however, a very early development is reported. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293233

    authors: Georgiew DB,Skortcheva I,Abadjiew V

    更新日期:1990-01-01 00:00:00

  • Maternal and perinatal outcome in nulliparous women aged 35 and older.

    abstract:OBJECTIVE:To compare the maternal and perinatal outcome of nulliparous women 35 years and older at the time of delivery with nulliparous women 25-29 years old. METHODS:A retrospective review of maternal and newborn records of singleton gestations only for first birth in women aged 35 and older (study group n = 143) we...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000064689

    authors: Ziadeh SM

    更新日期:2002-01-01 00:00:00

  • Role of T-cell cytokines in decidua and in cumulus oophorus during pregnancy.

    abstract::We focus on the roles of decidual and cumulus oophorus T cells. It was suggested that Th1-type cytokines (IFN-gamma and TNF-beta), which promote allograft rejection, may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-5, IL-10) inhibiting the Th1 responses promote allograft tolerance and therefore may i...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000101738

    authors: Piccinni MP

    更新日期:2007-01-01 00:00:00

  • Heart rate and blood pressure response and metabolic changes in the sheep fetus following reduction of uterine blood flow.

    abstract::The cardiovascular and metabolic responses during acute fetal hypoxia were studied in 7 pregnant sheep near term. Complete reduction of uterine flow (UBF) for 180 s was performed in 13 experiments by inflating a balloon positioned in the maternal aorta. Fetal heart rate (FHR), systolic and diastolic blood pressure (BP...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299425

    authors: Künzel W,Kastendieck E,Hohmann M

    更新日期:1983-01-01 00:00:00

  • Low myometrial glycogen content compared with rectus muscle in term pregnant women before labor.

    abstract::Glycogen, glucose, some nucleosides and purine base derivatives were determined in biopsies from 10 term pregnant women undergoing elective cesarean sections before labor. The concentrations were compared in the biopsies which were cut from isthmus and fundus of the uterus and m. rectus abdominis. M. rectus biopsies h...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010086

    authors: Steingrímsdóttir T,Ronquist G,Ulmsten U,Waldenström A

    更新日期:1999-01-01 00:00:00

  • Partial hydatidiform mole in the fallopian tube.

    abstract::An extremely rare case of partial hydatidiform mole located in the right Fallopian tube was diagnosed by ultrasonography and computed tomography. The lesion was excised, and the human chorionic gonadotropin (HCG) level in early morning urine fell below 1,000 IU/ml on postoperative day 11, and the serum HCG-beta level ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292708

    authors: Terada S,Suzuki N,Uchide K,Akasofu K

    更新日期:1993-01-01 00:00:00

  • Women with gestational diabetes develop glucose intolerance with high frequency within one year postpartum.

    abstract:OBJECTIVE:To investigate the incidence of glucose intolerance postpartum in women with gestational diabetes (GDM) and assess body weight, cholesterol and triglyceride concentrations after delivery. METHODS:This was a study of an initial cohort of 100 women with GDM who were tested at 6 weeks, 6 months, and 1 year post...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000331652

    authors: Saucedo R,Zarate A,Basurto L,Hernandez M,Puello E,Campos S,Moreno E

    更新日期:2012-01-01 00:00:00

  • Antimicrobial activity of human follicular fluids.

    abstract::The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of anti...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074103

    authors: Stepanović S,Djukić S,Veljković M,Arsić B,Garalejić E,Ranin L

    更新日期:2003-01-01 00:00:00

  • Are the histological and ultrastructural features of endometrial carcinomas reliable indicators of their steroid receptor content?

    abstract::The histological and ultrastructural features of 15 endometrial carcinomas were analyzed and recorded without knowledge of the steroid receptor content which was determined in the cytosol of the tumor tissue. Serum levels of estrogens were determined in all patients. The importance of this simultaneous determination o...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299521

    authors: Genton CY,Büchi KA

    更新日期:1982-01-01 00:00:00

  • Ureteral blockage as a complication of Burch colposuspension: report of 6 cases.

    abstract::Burch colposuspension for correction of urinary incontinence is rarely followed by complications. A very rarely described complication is ureteral kinking, which tends to occur in patients with previous pelvic surgeries. We present 6 additional cases of this rare complication and recommend appropriate intraoperative d...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293398

    authors: Ferriani RA,Silva de Sá MF,Dias de Moura M,Charaffedine MN,Hockgreb de Freitas Júnior A

    更新日期:1990-01-01 00:00:00

  • Ectopic pregnancy rates after frozen versus fresh embryo transfer: a meta-analysis.

    abstract:BACKGROUND/AIMS:The aim of this meta-analysis was to determine whether frozen embryo transfer (ET) increases ectopic pregnancy (EP) rate compared with fresh ET. METHODS:A meta-analysis was performed of data from seven comparative studies including 13,059 pregnancies that resulted from nondonor in vitro fertilization c...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,meta分析

    doi:10.1159/000213048

    authors: Jee BC,Suh CS,Kim SH

    更新日期:2009-01-01 00:00:00

  • Association between polymorphisms in sclerostin, dickkopfs and secreted frizzled-related protein genes and bone mineral density in postmenopausal Korean women.

    abstract:BACKGROUND/AIMS:The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in sclerostin (SOST), dickkopf (DKK), secreted frizzled-related protein (sFRP) genes and bone mineral density (BMD) in postmenopausal Korean women. METHODS:The SOST, Wnt inhibitory factor 1 (WIF1...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000358389

    authors: Lee DO,Kim H,Ku SY,Kim SH,Kim JG

    更新日期:2014-01-01 00:00:00

  • Advantage or disadvantage of episiotomy compared with spontaneous perineal laceration.

    abstract::In a prospective clinical investigation of 2,144 deliveries, we elucidate the indications for episiotomy and how different methods of anesthesia affect the frequency of episiotomy and the perineal problems after episiotomy compared with those after spontaneous perineal laceration. We found a significantly higher infec...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293161

    authors: Larsson PG,Platz-Christensen JJ,Bergman B,Wallstersson G

    更新日期:1991-01-01 00:00:00

  • Tissue plasminogen activator and plasminogen activator inhibitors of types 1 and 2 in amniotic fluid before labour and after childbirth.

    abstract::We measured three selected components of the fibrinolytic system in amniotic fluid of 36 parturient women, i.e. the antigen of tissue plasminogen activator (tPA) and antigens of plasminogen activator inhibitor of type 1 (PAI-1) and type 2 (PAI-2). The ELISA method was used. During labour, the level of each of the stud...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292387

    authors: Uszyński M,Uszyński W,Kiełkowski A

    更新日期:1995-01-01 00:00:00

  • Surgical treatment of tuberculous paraparesis in the third trimester: a report of two cases and review of the literature.

    abstract:BACKGROUND:Tuberculous paraplegia as a consequence of spinal infiltration in pregnancy is reported to be rare. Analysis of the current literature produces few case studies that report successful outcomes. Delay in diagnosis and treatment may ultimately result in an irreversible neurological deficit. The potential impli...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000235869

    authors: Loughenbury P,Pavlou G,Dunsmuir R

    更新日期:2009-01-01 00:00:00