Abstract:
:The aim of the present study was to investigate whether women with endometriosis displayed a decreased lymphokine-activated killer (LAK) activity. In 15 women with and 7 women without endometriosis the cytotoxicity against four different tumor cell lines--K562, the endometrium carcinomas AN3CA and RL95, the natural-killer (NK)-resistant Daudi cell line--was investigated, using either freshly isolated peripheral blood mononuclear cells (PBMC) or recombinant interleukin (IL)-2-stimulated PBMC. In 5 additional women collagenase-DNase-digested endometrium was used, to investigate whether recombinant IL-2-activated lymphocytes displayed an increased cytotoxicity against fresh and cultured endometrial cells. The cytotoxicity of unstimulated PBMC toward K562, AN3CA and RL95 target cells was decreased in women with endometriosis compared to women without endometriosis (p < 0.05, for all). After recombinant IL-2 stimulation the cytotoxicity toward the four different target cells increased significantly, both in women with and without endometriosis. There was no difference in LAK-mediated cytotoxicity against the four tumoral cells between women with and without endometriosis. Significant LAK activity was demonstrated against both fresh and cultured (72 h) endometrial cells. The cytotoxicity of autologous lymphocytes against cultured endometrial cells was 31.0 +/- 17 versus 67.4 +/- 5.8%, using lymphocytes cultured in medium without and with recombinant IL-2, respectively (paired t test, p < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Oosterlynck DJ,Lacquet FA,Waer M,Koninckx PRdoi
10.1159/000292556subject
Has Abstractpub_date
1994-01-01 00:00:00pages
185-90issue
3eissn
0378-7346issn
1423-002Xjournal_volume
37pub_type
杂志文章abstract:OBJECTIVE:To investigate normal human placental growth longitudinally throughout the second and third trimesters using MRI. METHODS:Twenty normal, first-time singleton pregnancies were scanned 7 times between the 14th and 38th week of gestation, at 4-week intervals, using MRI. Placental volumes were measured in both s...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000452661
更新日期:2017-01-01 00:00:00
abstract::Breast involvement in ovarian cancer is extremely rare. We report a case of solitary breast metastasis from ovarian carcinoma in a 43-year-old white woman, 3 months following diagnosis of ovarian cancer. The diagnostic, therapeutic and prognostic aspects as well as a review of the literature of this uncommon site of m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052946
更新日期:2001-01-01 00:00:00
abstract::Maternofetal transfer of ritodrine and its effect on placental glucose and oxygen consumption were studied using a recycling perfusion of maternal and fetal circulations of an isolated cotyledon of a term human placenta. 3H-labeled ritodrine was introduced into the maternal side of the perfusion system. Transfer was c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292983
更新日期:1991-01-01 00:00:00
abstract::The theory that the Th1 and Th2 cell ratio shifts towards Th2 dominance during pregnancy may improve fetal survival has gained support from recent studies. Also, the variation in the Th1/Th2 cell ratio is reportedly associated with intrauterine growth retardation and preeclampsia. On the basis of these findings, the a...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000010328
更新日期:2000-01-01 00:00:00
abstract::Immunocytochemical study in paraffin sections of human endometrium showed that the receptor contents for both oestrogen and progesterone receptors were lower than in the frozen sections although the staining patterns were similar in these two section types. Pretreating the specimens with proteolytic enzymes like tryps...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292422
更新日期:1995-01-01 00:00:00
abstract::It is recognised that there is a non-reactive status in the maternal immune system during normal pregnancy as it fails to recognise the fetus which is an allograft. The present study was aimed to understand the nature of cell-mediated immune response and the presence of immunosuppressive factors during human pregnancy...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294838
更新日期:1992-01-01 00:00:00
abstract::If we see a young, phenotypically female patient with an XY karyotype, it is of great importance to differentiate between the testicular feminization syndrome and gonadal dysgenesis. Patients with testicular feminization will always have normal testes, which are situated either in the ovarian fossa or in the inguinal ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293367
更新日期:1990-01-01 00:00:00
abstract::Severe fetal distress was produced in 16 fetal dogs by successive and/or prolonged occlusion of the maternal abdominal aorta in an acute surgical preparation, and was characterized in fetal arterial blood of 7.06 for pH, 10 mm Hg for O2, 127 mm Hg for CO2, and fetal heart rate decelerations. Five fetuses recovered spo...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000294837
更新日期:1992-01-01 00:00:00
abstract::The possibility to predict a large infant during pregnancy was assessed using data from a prospective cohort study of 537 singleton pregnancies with term deliveries. Maternal characteristics, symphysis fundal height and ultrasound measurements were used in multivariate analyses for the prediction of an infant with a b...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292658
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. CASE:We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on transvaginal ultrasound and color Do...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000141647
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The role of defective fimbrio-ovarian relation in cases of unexplained infertility has not been extensively studied. The aim of the study was to assess the role of fimbrio-ovarian relation as an investigative modality in women with unexplained infertility. We also aimed to evaluate the efficacy of superovu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000086004
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIM:To evaluate the efficacy and tolerability of postoperative depot medroxyprogesterone acetate (DMPA) versus postoperative continuous oral contraceptive (OC) pills in the treatment of endometriosis-associated pain. METHODS:After a conservative surgery, 84 patients with symptomatic endometriosis were rando...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000337713
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We sought to compare the pullout strengths of the sacral end of the sacrocolpopexy mesh when attached using one suture at the first versus second sacral vertebral level (S1 vs. S2) in female cadaveric pelvises. METHODS:The sacral vertebrae were isolated in 9 unembalmed female cadavers, and segments of polyp...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000338892
更新日期:2012-01-01 00:00:00
abstract::The concentration of P29, a phosphoprotein related to estradiol receptor (RE), was measured by an immunoradiometric assay in human breast cancer cytosol and the results compared with the levels of RE and progesterone receptors (RP), as measured by the classical ligand-binding assay. Good linear correlation was found b...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293689
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in sclerostin (SOST), dickkopf (DKK), secreted frizzled-related protein (sFRP) genes and bone mineral density (BMD) in postmenopausal Korean women. METHODS:The SOST, Wnt inhibitory factor 1 (WIF1...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000358389
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to evaluate oxidative protein damage (OPD) by investigating protein carbonyl (PCO) and nitrotyrosine (NT) levels, oxidative stress by total thiol (T-SH), erythrocyte glutathione (GSH) and nitric oxide (NO) levels in women receiving hormone replacement therapy (HRT). MATERIALS AND ME...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000067718
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To clarify the alteration of maternal-fetal mixed lymphocyte reaction (MLR) in intrahepatic cholestasis of pregnancy (ICP). METHODS:Twenty-two patients with intrahepatic cholestasis of pregnancy and 21 normal pregnant women were recruited into the present study. Of patients with ICP, 5 also experienced pregn...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000068381
更新日期:2002-01-01 00:00:00
abstract::We treated a patient with an ovarian tumor histologically consisting of an endometrial cyst, dermoid cyst and mucinous cystadenoma, in the same ovary. A comparative study between ultrasonic and histological findings was done. The usefulness, drawbacks and limitations in the ultrasonic evaluation of ovarian tumors are ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293646
更新日期:1989-01-01 00:00:00
abstract::We examined the fetal circulatory responses to maternal blood loss in pregnant women during the third trimester. Seven healthy women with placenta previa and singleton pregnancies underwent phlebotomies in an autologous donation program. Four hundred milliliters of blood was collected within 15 min at 34 and 35 weeks ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000052915
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate maternal serum transformed alpha-fetoprotein (MSt-AFP) levels, a new molecular conformation of AFP was used in cases of threatened preterm labor (TPL). METHODS:Prospective case-control study. Maternal serum levels of classical AFP and transformed AFP (t-AFP) were compared between 2 groups m...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000233239
更新日期:2009-01-01 00:00:00
abstract::Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cerv...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292372
更新日期:1995-01-01 00:00:00
abstract::A case control study was performed to examine possible morbidity associated with Chlamydia trachomatis in 15 pregnant women with idiopathic preterm premature rupture of the membranes (PROM; group A), and in two control groups, 35 healthy preterm pregnant women (group B), and 43 healthy pregnant women at term (group C)...
journal_title:Gynecologic and obstetric investigation
pub_type: 临床试验,杂志文章
doi:10.1159/000293249
更新日期:1990-01-01 00:00:00
abstract::ABO blood group was analyzed in 70 patients with hydatidiform mole and 53 patients with malignant trophoblastic disease. 319 healthy pregnant women served as controls. The distribution of ABO blood groups in patients with hydatidiform mole did not deviate significantly from the distribution in the controls. There was ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298967
更新日期:1985-01-01 00:00:00
abstract::To elucidate the mechanism of the type 2 carbohydrate chain accompanying the development of endometrial cancer, we studied the expression of beta-1,4-galactosyltransferase (beta-1,4GT) in normal endometrial and endometrial cancer tissues. An immunohistochemical study revealed that beta-1,4GT was diffusely positive in ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010158
更新日期:1999-01-01 00:00:00
abstract::During a 9-year period 61 Israeli Jewish Patients with histologically confirmed invasive squamous cell carcinoma of the uterine cervix (SUC) were treated by irradiation alone. A large proportion of the patients (44.2%) were more than 60 years old and only 27.9% were diagnosed as having stage IB disease. This is attrib...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299404
更新日期:1983-01-01 00:00:00
abstract::The aims of the present study were: (a) to examine whether it was possible to measure women's cognitive appraisals hourly during the whole process of labor and delivery, and (b) to explore how the appraisals varied during labor. Measurements from 12 nulliparous women are presented. The findings indicate that it is pos...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000010209
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Single-port laparoscopy (LESS) utilizes a single, multichannel port in an attempt to decrease postoperative pain, while enhancing cosmesis and minimizing the potential risks and morbidities associated with the multiple ports used in conventional laparoscopy. METHODS:We performed a retrospective study examin...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000367659
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000336409
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. METHODS:Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511440
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVE:To perform a health economics analysis of 5 screening programs for osteoporosis in perimenopausal Thai women comparing two alternatives; without intervention and universal treatment without screening. DESIGN:A decision analysis was performed to evaluate five screening strategies: Dual energy X-ray absorptiom...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000092803
更新日期:2006-01-01 00:00:00