Maternal free thyroxine and thyroxine-binding globulin during pregnancy ending in congenital malformations in the offspring.

Abstract:

:Thyroxine-binding globulin (TBG) and free thyroxine (FT4) were studied in 172 apparently healthy women giving birth to malformed children. The malformations were divided into two groups: minor malformations (group A) and major malformations (group B). The blood samples were usually drawn in the first trimester. Group A showed no significant difference in TBG values compared to women with healthy children. Group B showed lower, but not significantly lower values in earlier pregnancy. However, from the 15th-16th week of pregnancy the TBG values were significantly lower. The FT4 values were in the hyperthyroid range in as much as 20% of the women, compared to the reported rate of 0.2% hyperthyroidism in pregnant women.

journal_name

Gynecol Obstet Invest

authors

Skjöldebrand Sparre LS

doi

10.1159/000293608

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

19-21

issue

1

eissn

0378-7346

issn

1423-002X

journal_volume

27

pub_type

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