Relationship between recurrent miscarriage and insulin resistance.

Abstract:

AIMS:To investigate the differences in insulin resistance between women with recurrent miscarriage and those with normal pregnancy. METHODS:Pregnant women with a history of recurrent miscarriage were included in the patient group (n = 97), while those with no history of abnormal pregnancy were included in the control group (n = 52). Both groups consented to undertake an oral glucose tolerance test and insulin-releasing test between the 5th and 13th weeks of pregnancy. RESULTS:(1) Levels of fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index, and homeostasis model assessment β function were not statistically significantly different (p < 0.05) between the two groups. (2) The area under the curve of glucose and area under the curve of insulin were higher in the patient group than in the control group. The composite insulin sensitivity index of the patient group was lower than that of the control group. The differences in these three parameters between the groups were statistically significant (p < 0.05). CONCLUSION:Women with a history of recurrent miscarriage are at an increased risk for insulin resistance during the first trimester of a new pregnancy.

journal_name

Gynecol Obstet Invest

authors

Wang Y,Zhao H,Li Y,Zhang J,Tan J,Liu Y

doi

10.1159/000325165

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

245-51

issue

4

eissn

0378-7346

issn

1423-002X

pii

000325165

journal_volume

72

pub_type

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