The combined effect of a GnRH analog in premenopause plus postmenopausal estrogen deficiency for the treatment of uterine leiomyomas in perimenopausal women.

Abstract:

:Thirty-four perimenopausal women with uterine leiomyomas were treated with intramuscular injections of leuprolide acetate depot each 28 days for 6 cycles, and 12 of them after 168 days of no medication underwent a second 6-month therapy cycle. At the end of the observation period the expected improvement during treatment was maintained at cessation of therapy in 15 patients, due to the effect of the natural postmenopausal estrogen deficiency. Only 3 women underwent hysterectomy, due to the regrowth to baseline values of uterine size. It is concluded that the therapy with gonadotropin-releasing hormone analogs in perimenopause offers an effective alternative to surgery in the treatment of uterine leiomyomas.

journal_name

Gynecol Obstet Invest

authors

de Aloysio D,Altieri P,Pretolani G,Romeo A,Paltrinieri F

doi

10.1159/000292391

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

115-9

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

39

pub_type

杂志文章
  • Impaired mixed lymphocyte reaction in intrahepatic cholestasis of pregnancy.

    abstract:OBJECTIVE:To clarify the alteration of maternal-fetal mixed lymphocyte reaction (MLR) in intrahepatic cholestasis of pregnancy (ICP). METHODS:Twenty-two patients with intrahepatic cholestasis of pregnancy and 21 normal pregnant women were recruited into the present study. Of patients with ICP, 5 also experienced pregn...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000068381

    authors: Dong M,Xie X,Wang Z,He J,Zhou J,Cheng Q

    更新日期:2002-01-01 00:00:00

  • Veralipride for hot flushes during gonadotropin-releasing hormone agonist treatment.

    abstract::Hot flushes are the commonest symptom induced by gonadotropin-releasing hormone agonists (GnRHa). We performed an open observational trial to evaluate the efficacy of veralipride, an antidopaminergic drug, in reducing hot flushes in 25 premenopausal women treated with a GnRHa for endometriosis (8 subjects) or menorrha...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000292736

    authors: Vercellini P,Vendola N,Colombo A,Passadore C,Trespidi L,Crosignani PG

    更新日期:1992-01-01 00:00:00

  • Gestational diabetes: an evaluation of serum fructosamine as a screening test in a high-risk population.

    abstract:AIM:To evaluate the value of serum fructosamine as a screening test for gestational diabetes mellitus (GDM). METHODS:849 pregnant women underwent the one-step 75 g oral glucose tolerance test (OGTT) for universal screening of GDM. The fasting serum fructosamine (cFruc) was assessed using the area under the receiver op...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000318705

    authors: Agarwal MM,Dhatt GS,Othman Y,Ljubisavljevic MR

    更新日期:2011-01-01 00:00:00

  • Metastatic choriocarcinoma presenting in a gravid woman.

    abstract::Choriocarcinoma coexistent with an intrauterine pregnancy is rare and requires decisions affecting mother and child to treat this aggressive tumor. An instance of this situation is presented to highlight clinical circumstances that warrant departure from accepted dogma. Pathologic aspects of choriocarcinoma are also d...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000363234

    authors: Byrd K,Seay R,Bechert CJ,Maxwell GL,Bicher A

    更新日期:2015-01-01 00:00:00

  • Transient bilateral osteoporosis of the hip in pregnancy. A case report and review of the literature.

    abstract::Osteoporosis of the hip is a rare complication of pregnancy, the diagnosis of which can only be determined by radiologic means. Differentiation between osteonecrosis and osteoporosis remains problematic in some cases. Magnetic resonance imaging was reported as useful for the diagnosis of osteoporosis. Treatment of ost...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052910

    authors: Axt-Fliedner R,Schneider G,Seil R,Friedrich M,Mink D,Schmidt W

    更新日期:2001-01-01 00:00:00

  • Serum-specific antibodies for Chlamydia trachomatis in preterm premature rupture of the membranes.

    abstract::A case control study was performed to examine possible morbidity associated with Chlamydia trachomatis in 15 pregnant women with idiopathic preterm premature rupture of the membranes (PROM; group A), and in two control groups, 35 healthy preterm pregnant women (group B), and 43 healthy pregnant women at term (group C)...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000293249

    authors: Cohen I,Tenenbaum E,Fejgin M,Michaeli G,Beyth Y,Sarov I

    更新日期:1990-01-01 00:00:00

  • Postoperative depot medroxyprogesterone acetate versus continuous oral contraceptive pills in the treatment of endometriosis-associated pain: a randomized comparative trial.

    abstract:BACKGROUND/AIM:To evaluate the efficacy and tolerability of postoperative depot medroxyprogesterone acetate (DMPA) versus postoperative continuous oral contraceptive (OC) pills in the treatment of endometriosis-associated pain. METHODS:After a conservative surgery, 84 patients with symptomatic endometriosis were rando...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000337713

    authors: Cheewadhanaraks S,Choksuchat C,Dhanaworavibul K,Liabsuetrakul T

    更新日期:2012-01-01 00:00:00

  • Elevated immunoreactivity against class I histone deacetylases in adenomyosis.

    abstract:BACKGROUND/AIMS:Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women with and without adenomyosis. METHODS:The ectopic and homologous eu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000336409

    authors: Liu X,Nie J,Guo SW

    更新日期:2012-01-01 00:00:00

  • Heparanase expression and angiogenesis in endometrial cancer.

    abstract::Human heparanase has been shown to function in tumor progression, metastatic spread, and tumor angiogenesis. The aim of the present study was to assess heparanase expression in endometrial cancer in correlation with neovascularization and clinicopathological factors. Forty endometrial cancers were obtained from previo...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072821

    authors: Watanabe M,Aoki Y,Kase H,Tanaka K

    更新日期:2003-01-01 00:00:00

  • Early development of HELLP syndrome: a case report.

    abstract::The HELLP syndrome is a severe complication of pregnancy. It usually occurs in the middle of the third trimester. In our case, however, a very early development is reported. ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293233

    authors: Georgiew DB,Skortcheva I,Abadjiew V

    更新日期:1990-01-01 00:00:00

  • Outpatient Hysteroscopic Polypectomy: Bipolar Energy System (Versapoint®) versus Mechanical Energy System (TRUCLEAR System®) - Preliminary Results.

    abstract:HYPOTHESIS:The new hysteroscopic system with mechanical energy is an effective outpatient technique for diagnosis and treatment that has certain advantages over conventional hysteroscopy in the management of endometrial polyps. OBJECTIVES:Our primary objective was to assess the total duration of hysteroscopy and polyp...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000377700

    authors: Rovira Pampalona J,Degollada Bastos M,Mancebo Moreno G,Ratia Garcia E,Buron Pust A,Mateu Pruñonosa JC,Guerra Garcia A,Carreras Collado R,Bresco Torras P

    更新日期:2015-01-01 00:00:00

  • Sacral mesh pullout strength based on suture location for sacrocolpopexy.

    abstract:BACKGROUND:We sought to compare the pullout strengths of the sacral end of the sacrocolpopexy mesh when attached using one suture at the first versus second sacral vertebral level (S1 vs. S2) in female cadaveric pelvises. METHODS:The sacral vertebrae were isolated in 9 unembalmed female cadavers, and segments of polyp...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000338892

    authors: Shippey S,Sutter E,Belkoff SM,Gutman R,Chen CC

    更新日期:2012-01-01 00:00:00

  • Thermal artifact after three techniques of loop excision of the transformation zone: a comparative study.

    abstract:AIMS:To compare a surgical-margin thermal artifact in 3 techniques of loop excision of the transformation zone (LETZ). METHODS:The histopathologic specimens from 140 patients who underwent 3 techniques of LETZ with different electrosurgical units (large loop used with a Valleylab, large loop used with an Ellman Surgit...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000333438

    authors: Boonlikit S,Yanaranop M

    更新日期:2012-01-01 00:00:00

  • Vacuum aspiration at therapeutic abortion: blood loss at operation in multigravid women.

    abstract::Therapeutic abortion by vacuum aspiration in the first trimester was carried out on 129 healthy multigravid women. The loss of haemoglobin at operation was estimated and the volume of blood calculated. The figures were compared to those in a group of primigravid women earlier reported. Blood loss increases with gestat...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000300997

    authors: Sandström B,Segerbrand E,Solheim F

    更新日期:1978-01-01 00:00:00

  • Comparison of the long-term effects of estrogen and clomiphene citrate on pituitary and uterine function in ovariectomized rats.

    abstract::The effects of estradiol-17 beta (E2) and clomiphene citrate (CC) on pituitary-uterine function in ovariectomized (OVX) rats were compared in two experiments. In experiment 1, CC completely blocked E2 stimulation of uterine weight when administered concurrently for 10 and 30 days. In experiment 2, content of total (oc...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293095

    authors: Brown JL,Byrd SJ,Mitchell AS,Nelson MF,Young RL,Chakraborty PK

    更新日期:1991-01-01 00:00:00

  • Safety of therapeutic doses of tinzaparin during pregnancy.

    abstract:BACKGROUND/AIMS:Low molecular weight heparin is recommended for the treatment of venous thromboembolism (VTE) during pregnancy. However, there are few reliable data regarding the safety of therapeutic doses of tinzaparin in this setting. The objective of this study was to assess the safety of once-daily therapeutic dos...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000367846

    authors: Parent F,Deruelle P,Sanchez O,Meyer G,Girard P,Jilwan F,Boyer-Neumann C,Wolf M,Simonneau G

    更新日期:2015-01-01 00:00:00

  • Blood loss during transvaginal oocyte retrieval.

    abstract:BACKGROUND/AIMS:Limited information is available regarding the quantity of blood loss associated with uncomplicated transvaginal oocyte retrieval. The aim of the present study was evaluating the quantity of such a loss. METHODS:One hundred and fifty consecutive women undergoing oocyte retrieval were recruited. They un...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000158649

    authors: Ragni G,Scarduelli C,Calanna G,Santi G,Benaglia L,Somigliana E

    更新日期:2009-01-01 00:00:00

  • Are blood flow velocity waveforms related to umbilical cord acid-base status in the human fetus?

    abstract::Doppler blood flow velocity waveforms from fetal umbilical artery, descending aorta, internal carotid artery and maternal uterine arteries were recorded in 50 fetuses near term undergoing cesarean section before the onset of labor in order to evidence eventual relationships with the fetal acid-base status. The primary...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293652

    authors: Arduini D,Rizzo G,Romanini C,Mancuso S

    更新日期:1989-01-01 00:00:00

  • Transvaginal ultrasound is an effective method for screening in polycystic ovarian disease: preliminary study.

    abstract::To assess the usefulness of transvaginal ultrasound scanning (TVS) for screening in polycystic ovarian (PCO) disease, we symptomatically and endocrinologically compared 9 cases (group A) with PCO noted by transabdominal ultrasound scanning (TAS) with 8 cases (group B) with PCO noted by TVS only. No difference in the m...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000293210

    authors: Takahashi K,Nishigaki A,Eda Y,Yamasaki H,Yoshino K,Kitao M

    更新日期:1990-01-01 00:00:00

  • Urinary excretion, osmolarity and electrolytes after bolus-injection of fenoterol in female rabbits.

    abstract::The effects of bolus injections of 1.0-80.0 micrograms/kg body weight fenoterol on urinary excretion, osmolarity and electrolytes were studied in unanesthetized, water-loaded rabbits. In animals infused initially with isotonic solution over 2 h with 60 ml/h and thereafter over 10 h with 45 ml/h, urine excretion was 53...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299169

    authors: Grospietsch G,Ulbrich R,Saul U,Fenske M,Ensink FB,Kuhn W

    更新日期:1984-01-01 00:00:00

  • A clinicohysteroscopic scoring system of intrauterine adhesions.

    abstract::We propose a new scoring system for intrauterine adhesions (IUA) that may predict the prognosis after hysteroscopic adhesiolysis. We analyzed hysteroscopic findings and clinical data of patients diagnosed as having IUA by reviewing previously published hysteroscopic classifications of IUA. The data were subjected to e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010305

    authors: Nasr AL,Al-Inany HG,Thabet SM,Aboulghar M

    更新日期:2000-01-01 00:00:00

  • Angiogenesis in endometriosis and angiogenic factors.

    abstract::Among angiogenic factors, VEGF secreted from activated macrophages under the influence of ovarian steroids, IL-8 expressed in endometrial stromal cells, and basic FGF expressed in endometriotic tissue and PD-ECGF expressed in lining epithelial cells independently of the sex steroidal milieu might contribute to the cha...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000052864

    authors: Fujimoto J,Sakaguchi H,Hirose R,Wen H,Tamaya T

    更新日期:1999-01-01 00:00:00

  • Two Cases of True Uterine Artery Aneurysms Diagnosed during Pregnancy.

    abstract::We report 2 cases of true uterine artery aneurysms diagnosed during pregnancy. Both cases presented with nonspecific symptoms such as urethral obstruction, minimal vaginal bleeding and lower abdominal pain in the 2nd trimester. Both aneurysms were diagnosed by color Doppler ultrasound. In the first case labor was indu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000449384

    authors: Schlütter JM,Johansen G,Helmig RB,Petersen OB

    更新日期:2017-01-01 00:00:00

  • The special programme of research in human reproduction: forty years of activities to achieve reproductive health for all.

    abstract::The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of e...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 历史文章,杂志文章,评审

    doi:10.1159/000343067

    authors: Benagiano G,d'Arcangues C,Harris Requejo J,Schafer A,Say L,Merialdi M

    更新日期:2012-01-01 00:00:00

  • Placental proteins in male serum.

    abstract::Placental proteins such as human chorionic gonadotrophin (hCG), Schwangerschaftsprotein 1 (SP1) and pregnancy-associated plasma protein A (PAPP-A) are found in the blood of pregnant women and in subjects suffering from cancer. They can also be found in the blood of healthy non-pregnant women and in the seminal fluid o...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298985

    authors: Klopper A,Ahmed AG,Bersinger N,Urbaniak S

    更新日期:1985-01-01 00:00:00

  • Successful treatment of deep dyspareunia and primary dysmenorrhea with laparoscopic uterosacral nerve ablation (LUNA) procedure.

    abstract::Deep dyspareunia, often described as pain resulting from pelvic thrusting during sexual intercourse, is relatively common and has many causes. To date, feasible surgical interventions for deep dyspareunia are very rare. The two procedures which have been mentioned in the literature for the treatment of deep dyspareuni...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000087562

    authors: Juang CM,Yen MS,Horng HC,Yu HC,Chang CM,Yeh JY

    更新日期:2006-01-01 00:00:00

  • Urodynamic investigation of women operated on for genuine stress incontinence.

    abstract::Anterior colporrhaphy (Kelly-Stoeckel suture) was performed on 22 women suffering from grade-I or grade-II genuine stress incontinence. Urodynamic investigation was performed on every patient before surgery and 6 months postoperatively. 21 patients were cured and 1 patient improved. After operation the functional uret...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010196

    authors: Matányi S,Acs N,Fontányi Z,Paulin F

    更新日期:1999-01-01 00:00:00

  • Uterine intravascular fetal material and coagulopathy at peripartum hysterectomy.

    abstract:BACKGROUND/AIMS:To test the hypothesis that obstetrical disseminated intravascular coagulopathy results from an excessive leakage of fetal material into the maternal circulation. METHODS:All peripartum hysterectomy cases for hemorrhage at two suburban Illinois hospitals over 10 years were included. Intravascular prese...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000332373

    authors: Benson MD,Cheema N,Kaufman MW,Goldschmidt RA,Beaumont JL

    更新日期:2012-01-01 00:00:00

  • Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension.

    abstract::The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role. Moreover, there is a significantly positive association between PE and later hypertension. Apolipoprotein J (apo J) plays an important role in stabilizing cell membranes at diverse fluid-tissue interfaces and might protect ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000086056

    authors: Chen M,Yuan Z,Shan K

    更新日期:2005-01-01 00:00:00

  • Introduction of human papillomavirus vaccination in Belgium, Luxembourg and the Netherlands.

    abstract:AIMS:To document progress with human papillomavirus (HPV) vaccine introduction in three closely related European countries, one with organized (the Netherlands) and two with opportunistic cervical cancer screening (Belgium and Luxembourg). METHODS:Experts involved in cervical cancer screening and national immunization...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000314010

    authors: Arbyn M,Simoens C,Van Damme P,Scharpantgen A,Meijer CJ,Beutels P

    更新日期:2010-01-01 00:00:00