Abstract:
:The relative fatty acid composition of serum lecithin was followed in groups of women during postmenopausal replacement therapy. The effects of estradiol valerate and ethinyl estradiol in two different doses, and the modulating influence of various progestogens and antiestrogens were compared. Unopposed estrogen treatment enhanced liver lecithin synthesis along pathway I, i.e. reduced the amount of stearic acid and increased the amount of palmitic acid. The effect was clearly dose-dependent and even the low dose of 10 micrograms of ethinyl estradiol was more potent than 2 mg of estradiol valerate. No qualitative difference between the two estrogens was recorded. The sequential addition of the antiestrogen tamoxifen significantly reduced the influence of ethinyl estradiol. Liver lecithin synthesis along pathway I may be stimulated by all estrogens and not only by 17C-alkylated compounds. The prostaglandin precursors, dihomogammalinolenic and arachidonic acid, showed a seemingly dose-dependent increase during estrogen treatment. The comparatively weaker effects of estradiol valerate on lipid metabolism should make this non-alkylated estrogen the first choice in clinical practice.
journal_name
Gynecol Obstet Investjournal_title
Gynecologic and obstetric investigationauthors
Ottosson UB,Lagrelius A,Rosing U,von Schoultz Bdoi
10.1159/000299096subject
Has Abstractpub_date
1984-01-01 00:00:00pages
296-302issue
6eissn
0378-7346issn
1423-002Xjournal_volume
18pub_type
杂志文章abstract:OBJECTIVE:To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells of cervical carcinoma patients. METHODS:Peripheral blood samples from 15 high-grade cervical squamous intraepithelial lesion (HSIL) patients, 24 cervical carcinoma patients, and 21 healthy controls were co...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000511440
更新日期:2020-12-04 00:00:00
abstract:OBJECTIVES:To investigate the signs, symptoms and changes in the vaginal milieu that could be associated with cervical human papillomavirus infection (CHPI). STUDY DESIGN:Women (n = 972) attending for contraceptive advice were tested for human papillomavirus in cervical samples. Results of gynecological history, exami...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291818
更新日期:1997-01-01 00:00:00
abstract::Subcutaneous heparin and plasma infusion were successfully used during an induced abortion in a young woman with familial antithrombin-III deficiency and a history of severe thrombotic episodes. :Women with herditary antithrombin-3 deficiency are exposed to a considerable risk of thrombosis during periods of thrombog...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299612
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND/AIMS:Adiponectin receptor 1 (ADIPOR1) is an identified receptor for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. The ADIPOR1 gene is a potential candidate gene in polycystic ovary syndrome (PCOS). The aim of this study is to assess the association between single-nu...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000356960
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine whether a diminished intrapartum amniotic fluid volume represents a risk of adverse neonatal outcome when it occurs in conjunction with prolonged labor. METHODS:The intrapartum amniotic fluid index (iAFI) was measured in 242 parturients over 35 weeks of gestation during 1st-stage labor, and the ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000049402
更新日期:2002-01-01 00:00:00
abstract::Twenty-four women with second-trimester cervical incompetence underwent emergency cerclage. The appropriateness of cervical cerclage was analyzed according to a scoring system (Cervical Incompetence Scale; CIS) which measures the degree of cervical effacement, cervical dilatation and protrusion of fetal membranes into...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293093
更新日期:1991-01-01 00:00:00
abstract::Gestational diabetes (GD), defined as carbohydrate intolerance with onset or first recognition during pregnancy, has a prevalence of 7% and is a growing problem worldwide. Infants born to mothers with GD are more likely to be large for gestational age, incur traumatic birth injury, require a stay in the intensive care...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,评审
doi:10.1159/000357616
更新日期:2014-01-01 00:00:00
abstract::A suburethral sling procedure using a Mersilene mesh has been performed in 24 patients. Six patients had recurrent incontinence after an unsuccessful past operation. A postoperative follow-up was done for an average of 24 months. Twenty-three patients were free of symptoms, while only 1 patient had recurrent incontine...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292521
更新日期:1994-01-01 00:00:00
abstract::The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all informati...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000478982
更新日期:2017-01-01 00:00:00
abstract:AIM:To compare the effect of suprapubic and transurethral catheterization on postvoid residual volumes (PRVs) after cystocele repair. METHODS:126 women who underwent pelvic organ prolapse surgery including cystocele repair were randomized to suprapubic or transurethral catheterization. At the third postoperative day, ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323827
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Cisplatin is used as a key drug for ovarian yolk sac tumor (YST), but relapse may occur. Details of the molecular mechanism responsible for cisplatin resistance remain unclear. METHODS:We established cisplatin-resistant ovarian YST cells (NOY1-CR) from parent NOY1. To characterize these cells, we examined c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000320744
更新日期:2011-01-01 00:00:00
abstract::To evaluate both the incidence of c-myc gene mutation and the relationship of this finding to the clinico-pathologic characteristics of patients with cervical cancer, a polymerase chain reaction (PCR)-based heteroduplex gel electrophoresis method was used to screen DNA extracted from 102 cervical invasive carcinomas r...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000291505
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Scar deciduosis provides a research model that enables us to assess the impact of decidua on the activity and quality of the immune cells infiltrating this scar tissue. This unique model allows us to examine these processes under conditions excluding the impact of placental cells which, along with decidual...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000111533
更新日期:2008-01-01 00:00:00
abstract:HYPOTHESIS:The new hysteroscopic system with mechanical energy is an effective outpatient technique for diagnosis and treatment that has certain advantages over conventional hysteroscopy in the management of endometrial polyps. OBJECTIVES:Our primary objective was to assess the total duration of hysteroscopy and polyp...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章,随机对照试验
doi:10.1159/000377700
更新日期:2015-01-01 00:00:00
abstract:AIMS:To investigate misoprostol use as a self-administered medical abortifacient and to explore the knowledge and availability of misoprostol and attitudes towards it among Saudi women. METHODS:A questionnaire-based cross-sectional study was conducted in obstetric and gynecological outpatient clinics at private and te...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000363238
更新日期:2014-01-01 00:00:00
abstract::We report a postmenopausal patient with serous papillary cystadenocarcinoma of the ovary associated with large abscess formation and estrogen production. Ovarian cancer accompanied by stromal function is an occasional event, but large abscess association is a rarity. The present case is thus even rarer. Her clinical c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292710
更新日期:1993-01-01 00:00:00
abstract::Highly evacuated (980 mbar) wound drainage systems according to Redon were used in 100 gynecologic laparotomies. In 96% of cases, no flask exchange was required before the system was removed. Bacteriological specimens from various locations of the Redon system showed minimal colonization with pathogenic bacteria. No c...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293758
更新日期:1988-01-01 00:00:00
abstract::Cesarean sections were performed in 24 cases before the end of the 32nd week of pregnancy. Despite the fact that the indications for the operations were severe obstetric complications, the perinatal mortality was 25%, which should be compared to 23% for all children born in Sweden at that age., 2 of the surviving chil...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299827
更新日期:1980-01-01 00:00:00
abstract:AIMS:The purpose was to investigate the influence of delivery mode on the postpartum regression of abnormal cervical cytology. METHODS:A retrospective review was conducted of 64 pregnant women with abnormal cervical cytology at Yonsei University Health System in Korea between 2001 and 2008. A Papanicolaou smear and pa...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000324500
更新日期:2011-01-01 00:00:00
abstract:AIM:This study aimed to clarify the genetic and epigenetic features of recurrent hydatidiform mole (RHM) in Japanese patients. METHODS:Four Japanese isolated RHM cases were analyzed using whole-exome sequencing. Villi from RHMs were collected by laser microdissection for genotyping and DNA methylation assay of differe...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000441780
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in sclerostin (SOST), dickkopf (DKK), secreted frizzled-related protein (sFRP) genes and bone mineral density (BMD) in postmenopausal Korean women. METHODS:The SOST, Wnt inhibitory factor 1 (WIF1...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000358389
更新日期:2014-01-01 00:00:00
abstract::The aim of the present experiments was to investigate a possible correlation between the occurrence of preeclampsia and the levels of norepinephrine in human myometrial biopsies obtained from the lower uterine segment at the time of cesarean section. Norepinephrine was measured directly by the technique of muscle CATS...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293271
更新日期:1990-01-01 00:00:00
abstract::We developed a model in which full-thickness human genital mucous membranes (fallopian tubes, endometrium) were heterotopically xenografted into the skin of severe combined immunodeficient (SCID) mice. The transplanted tissue retained its human phenotype for at least 4 weeks including the glandular epithelium, the lam...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292314
更新日期:1995-01-01 00:00:00
abstract::Recently some articles have been published in which the total lung profile has been introduced to determine the fetal lung maturation. In the present study the two-dimensional L/S ratio and the total lung profile, especially the phosphatidyl-glycerol content, are compared with the conventional one-dimensional L/S rati...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000299461
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Epithelial ovarian carcinoma produces steroid hormones that may be of prognostic importance. The steroids are mainly bound to plasma albumin and sex hormone-binding globulin. Alterations in plasma protein levels influence hormonal effects. As plasma prealbumin may reflect changes in the patient's clinical st...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292542
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Our objective was to evaluate the direct effect of tamoxifen citrate (TAM) on the endometrium, liver, breast tissue and the lipid profile in oophorectomized (OX) rats. STUDY DESIGN:An experimental animal study. MATERIAL AND METHODS:Forty-one mature rats (33 OX) were randomly divided into four groups and rec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000009933
更新日期:1998-01-01 00:00:00
abstract::Prophylactic antibiotic therapy is accepted for prevention of postceasarean infection in certain risk groups. Of the antibiotic regimens presented none appears superior. Patients having a cesarean section (CS) more than 6 h after membrane rupture were given three doses of cefuroxime (1.5 g every 8th hour) in a prospec...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293492
更新日期:1989-01-01 00:00:00
abstract::An attempt was made to verify the hypothesis that a low-lying placenta may be a factor leading to the dynamic form of cervical incompetence. A vaginal evaluation of the cervix was made in 143 pregnant women who by means of ultrasonographic method were found to have low-lying placentas. In as many as 68 out of the 143 ...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000298964
更新日期:1985-01-01 00:00:00
abstract::The possible interaction of the newly developed triazole antifungal SCH 39304 with low-dose combined oral contraceptives (OCs) was studied in 15 healthy women. Serum levels of ovarian and adrenocortical steroids and sex hormone-binding globulin (SHBG) were analyzed in samples collected during the OC cycles immediately...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000293003
更新日期:1991-01-01 00:00:00
abstract::Using a 4-MHz continuous-wave Doppler device, standard rates were established for resistance index (RI) and pulsatility index (PI) of uterine and arcuate arteries of 612 patients with uneventful pregnancies and deliveries. From 18 to 41 weeks of gestation, neither RI nor PI of uterine or arcuate arteries proved to var...
journal_title:Gynecologic and obstetric investigation
pub_type: 杂志文章
doi:10.1159/000292732
更新日期:1992-01-01 00:00:00