Pilot study: absorption and efficacy of multiple hormones delivered in a single cream applied to the mucous membranes of the labia and vagina.

Abstract:

BACKGROUND/AIMS:There is a lack of evidence in the literature supporting vaginal application of a combination hormone-containing cream for local and systemic symptom relief. This pilot study examined the extent of absorption of a single cream containing estriol, estradiol, progesterone, DHEA, and testosterone. METHODS:A combination cream was administered to 12 postmenopausal women in two differing doses over two independent time periods. Following 28 days (arm 1) and an additional 14 days (arm 2), measurement of hormones in saliva and blood and measurements of symptom relief, patient tolerability, and health-related quality of life (HRQoL) were obtained. RESULTS:The dosage and time of evaluation for study arm 1 was not ideal for providing documented increases in hormone levels. HRQoL measurements supported measured improvement in this arm. The second arm did document absorption of the various hormones when given vaginally. CONCLUSION:This study is the first documenting systemic absorption of multiple hormones by both saliva and blood as well as improvement of HRQoL. This therapy was generally well-tolerated with only 2 patients experiencing minor irritation, not necessitating discontinuation. Additional studies in larger numbers of patients will provide better knowledge for clinicians wanting to provide similar therapy at the lowest effective dose.

journal_name

Gynecol Obstet Invest

authors

Glaser RL,Zava DT,Wurtzbacher D

doi

10.1159/000128599

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

111-8

issue

2

eissn

0378-7346

issn

1423-002X

pii

000128599

journal_volume

66

pub_type

临床试验,杂志文章
  • Are the histological and ultrastructural features of endometrial carcinomas reliable indicators of their steroid receptor content?

    abstract::The histological and ultrastructural features of 15 endometrial carcinomas were analyzed and recorded without knowledge of the steroid receptor content which was determined in the cytosol of the tumor tissue. Serum levels of estrogens were determined in all patients. The importance of this simultaneous determination o...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299521

    authors: Genton CY,Büchi KA

    更新日期:1982-01-01 00:00:00

  • Repair of vaginal prolapse following penoscrotal flap vaginoplasty in a male-to-female transsexual.

    abstract::Penis and testicle amputation, vaginoplasty, and clitoroplasty are procedures that help male-to-female transsexuals to accept their body and to increase psychosocial well-being. We describe a successful correction of prolapse of the neovagina with abdominovaginal sacropexy in a male-to-female transsexual who had under...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000064559

    authors: Loverro G,Bettocchi C,Battaglia M,Cormio G,Selvaggi G,Di Tonno P,Selvaggi FP

    更新日期:2002-01-01 00:00:00

  • Normal serum relaxin in women with disabling pelvic pain during pregnancy.

    abstract::As part of a case control within cohort study 472 pregnant women answered a questionnaire post partum. Serum relaxin concentrations were measured by a homologous ELISA in samples collected from the women in the 30th week of pregnancy. Serum relaxin concentrations were not associated with pregnancy-associated pelvic pa...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292438

    authors: Petersen LK,Hvidman L,Uldbjerg N

    更新日期:1994-01-01 00:00:00

  • Plasma melatonin profile and hormonal interactions in the menstrual cycles of anovulatory infertile women treated with gonadotropins.

    abstract::The patterns of plasma melatonin, gonadotropins, sex steroids and prolactin were studied in anovulatory infertile females undergoing ovulation induction with hMG/hCG. Melatonin levels were found to fluctuate during the menstrual cycle of these subjects with a nadir at mid-cycle and peak occurring at the early follicul...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009977

    authors: Tang PL,Chan TY,Tang GW,Pang SF

    更新日期:1998-01-01 00:00:00

  • Risk Factors for Intrapartum Fever in Term Gestations and Associated Maternal and Neonatal Sequelae.

    abstract:AIM:To determine factors associated with intrapartum fever and to examine associated maternal and neonatal outcomes. METHODS:Retrospective study of patients between 360/7 and 420/7 gestational weeks who entered spontaneous or induced active labor and developed temperature ≥38°C; a similar group that did not develop fe...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000453611

    authors: Burgess APH,Katz JE,Moretti M,Lakhi N

    更新日期:2017-01-01 00:00:00

  • Endometriosis and genital anomalies: some histogenetic aspects of external endometriosis.

    abstract::Six cases with a coexistence of endometriosis and genital anomalies among 112 patients with external endometriosis and 90 patients with genital anomaly were detected. Three cases of severe endometriosis associated with uterovaginal duplication, unilateral renal agenesis and ipsilateral blind vagina and the latter in a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298899

    authors: Acién P

    更新日期:1986-01-01 00:00:00

  • Termination of pregnancy in a woman with hereditary antithrombin deficiency under antithrombotic protection with subcutaneous heparin and infusion of plasma.

    abstract::Subcutaneous heparin and plasma infusion were successfully used during an induced abortion in a young woman with familial antithrombin-III deficiency and a history of severe thrombotic episodes. :Women with herditary antithrombin-3 deficiency are exposed to a considerable risk of thrombosis during periods of thrombog...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299612

    authors: Jespersen J

    更新日期:1981-01-01 00:00:00

  • Use of chlorhexidine-releasing nylon fibres to reduce device-related uterine infections.

    abstract::Implantation of intrauterine devices (IUDs) is associated with an increased incidence of uterine infection, probably as a result of vaginal bacteria entering the uterus at the time of insertion. To reduce the incidence of IUD-related infections, the incorporation of antimicrobial agents into the tail of the device was...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000010256

    authors: Gard PR,Reynolds JP,Hanlon GW

    更新日期:2000-01-01 00:00:00

  • Can Genomic Amplification of Human Telomerase Gene and C-MYC in Liquid-Based Cytological Specimens Be Used as a Method for Opportunistic Cervical Cancer Screening?

    abstract:OBJECTIVE:To evaluate the effectiveness of five methods including the ThinPrep cytological test (TCT), liquid-based cytology, the human papillomavirus (HPV) test, detection of the TERC and C-MYC genes and visual inspection with acetic acid/Lugol's iodine (VIA/VILI) for opportunistic cervical cancer screening, and to ex...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000371760

    authors: Gao K,Eurasian M,Zhang J,Wei Y,Zheng Q,Ye H,Li L

    更新日期:2015-01-01 00:00:00

  • Antimicrobial activity of human follicular fluids.

    abstract::The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of anti...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074103

    authors: Stepanović S,Djukić S,Veljković M,Arsić B,Garalejić E,Ranin L

    更新日期:2003-01-01 00:00:00

  • Two Cases of True Uterine Artery Aneurysms Diagnosed during Pregnancy.

    abstract::We report 2 cases of true uterine artery aneurysms diagnosed during pregnancy. Both cases presented with nonspecific symptoms such as urethral obstruction, minimal vaginal bleeding and lower abdominal pain in the 2nd trimester. Both aneurysms were diagnosed by color Doppler ultrasound. In the first case labor was indu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000449384

    authors: Schlütter JM,Johansen G,Helmig RB,Petersen OB

    更新日期:2017-01-01 00:00:00

  • Outpatient Hysteroscopic Polypectomy: Bipolar Energy System (Versapoint®) versus Mechanical Energy System (TRUCLEAR System®) - Preliminary Results.

    abstract:HYPOTHESIS:The new hysteroscopic system with mechanical energy is an effective outpatient technique for diagnosis and treatment that has certain advantages over conventional hysteroscopy in the management of endometrial polyps. OBJECTIVES:Our primary objective was to assess the total duration of hysteroscopy and polyp...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000377700

    authors: Rovira Pampalona J,Degollada Bastos M,Mancebo Moreno G,Ratia Garcia E,Buron Pust A,Mateu Pruñonosa JC,Guerra Garcia A,Carreras Collado R,Bresco Torras P

    更新日期:2015-01-01 00:00:00

  • Is There a Benefit to Culturing Intra-Uterine Devices in Pelvic Inflammatory Disease?

    abstract:AIMS:The study aimed to compare the clinical course and disease severity between culture positive and culture negative patients with intra-uterine devices (IUD)-associated pelvic inflammatory disease (PID). METHODS:A retrospective study of all IUD-associated PID patients admitted to tertiary medical center between 201...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000490666

    authors: Fouks Y,Many A,Amit S,Levin I,Meiri A,Shinar S

    更新日期:2019-01-01 00:00:00

  • Preeclampsia and maternal heart rate variability.

    abstract::Maternal heart rate variability was evaluated by means of 24-hour Holter ECG monitoring in three groups of patients (15 preeclamptic, 15 women hospitalized due to other complications and 15 normal ambulatory pregnant women) in the 28th-33rd week of gestation. Heart rate variability was estimated by time and frequency ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000009949

    authors: Eneroth E,Storck N

    更新日期:1998-01-01 00:00:00

  • Tension-free vaginal tape procedure: an effective minimally invasive operation for the treatment of recurrent stress urinary incontinence?

    abstract::The aim of this study was to evaluate the results of tension-free vaginal tape (TVT) surgery in women with recurrent stress urinary incontinence (SUI). Fifty-one women with recurrent SUI were treated with TVT and followed prospectively for a minimum of 2 years according to a protocol. Twenty percent of the women had a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072942

    authors: Kuuva N,Nilsson CG

    更新日期:2003-01-01 00:00:00

  • Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysis.

    abstract::Proliferative activity of uterine leiomyomas from premenopausal (n = 44) and postmenopausal (n = 12) women was investigated by automatic image analysis on frozen tissue sections using immunohistochemistry with anti-proliferating cell nuclear antigen antibody. The quantitative proliferation index (QPI) in premenopausal...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292738

    authors: Lamminen S,Rantala I,Helin H,Rorarius M,Tuimala R

    更新日期:1992-01-01 00:00:00

  • Clinical effects of preoperative oestradiol treatment before vaginal repair operation. A double-blind, randomized trial.

    abstract::The objective of the study was to assess the effects of low-dose vaginal treatment with oestradiol before vaginal operation. In a double-blind randomized study including 43 postmenopausal women scheduled for vaginal repair operation for genital descensus, it was found that 7 patients suffered from concomitant urinary ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000292320

    authors: Mikkelsen AL,Felding C,Clausen HV

    更新日期:1995-01-01 00:00:00

  • Safety of therapeutic doses of tinzaparin during pregnancy.

    abstract:BACKGROUND/AIMS:Low molecular weight heparin is recommended for the treatment of venous thromboembolism (VTE) during pregnancy. However, there are few reliable data regarding the safety of therapeutic doses of tinzaparin in this setting. The objective of this study was to assess the safety of once-daily therapeutic dos...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000367846

    authors: Parent F,Deruelle P,Sanchez O,Meyer G,Girard P,Jilwan F,Boyer-Neumann C,Wolf M,Simonneau G

    更新日期:2015-01-01 00:00:00

  • Bacteroides fragilis, Streptococcus intermedius and group B streptococci in ascending infection of pregnancy. An animal experimental study.

    abstract::By means of bacteriological, histological and immunofluorescence methods, the ascending spread of endocervically inoculated bacteria was studied in 14 pregnant sheep. 8 ewes near term were exposed to group B streptococci, Bacteroides fragilis or Streptococcus intermedius for 2-4 days. 6 other animals in mid pregnancy ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299415

    authors: Evaldson G,Malmborg AS,Nord CE,Ostensson K

    更新日期:1983-01-01 00:00:00

  • Uteroplacental blood flow measurement using radioisotopes in small placentas.

    abstract::In 25 pregnant females with a placental weight below the 20th percentile uteroplacental blood flow measurements using 113mIn-transferrin were performed in the 3rd trimester of pregnancy. Twelve patients with pregnancy-induced hypertension (PIH) were compared to 13 females with normal blood pressures. The results of ut...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298931

    authors: Philipp K,Skodler WD,Pateisky N

    更新日期:1986-01-01 00:00:00

  • Laparoscopic ovarian cystectomy versus fenestration/coagulation or laser vaporization for the treatment of endometriomas: a meta-analysis of randomized controlled trials.

    abstract:AIM:To compare outcomes after laparoscopic ovarian cystectomy versus fenestration/coagulation or laser ablation for the treatment of endometriomas. METHODS:Studies were identified by searching the PubMed, EMBASE, SCOPUS, and Cochrane Central Register of Controlled Trials databases using the terms ovarian, endometrioma...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,meta分析

    doi:10.1159/000351165

    authors: Dan H,Limin F

    更新日期:2013-01-01 00:00:00

  • Mucocele of the vermiform appendix with sonographic appearance of an adnexal mass.

    abstract::Mucocele of the vermiform appendix is caused by mucus retention in its lumen, due to obstruction or hyperproduction. Appendiceal malignancy can be the underlying cause, making accurate preoperative diagnosis imperative. In women, it can sometimes present as an adnexal mass. A rare case of an appendiceal mucocele is pr...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000083680

    authors: Dragoumis K,Mikos T,Zafrakas M,Assimakopoulos E,Venizelos I,Demertzidis H,Bontis J

    更新日期:2005-01-01 00:00:00

  • Ovarian fibrothecoma: sonographic and histologic findings.

    abstract::The sonographic and histologic findings observed in 11 cases of ovarian fibrothecoma were compared, and an attempt was made to find a correlation between each histologic type of the tumor (pure thecoma, predominantly fibrous fibrothecoma, mixed fibrothecoma) and its sonographic appearance. The presence of a homogeneou...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000292992

    authors: Conte M,Guariglia L,Benedetti Panici P,Scambia G,Rabitti C,Capelli A,Mancuso S

    更新日期:1991-01-01 00:00:00

  • Placental clearance of lactate and bicarbonate in sheep.

    abstract::To determine the placental clearance of lactate and bicarbonate in sheep, the fetal side of an isolated cotyledon and the umbilical circulation of the total placenta were artificially perfused. The release and uptake of lactate and bicarbonate by the perfusion fluid and the fetomaternal concentration differences of th...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000299913

    authors: Kastendieck E,Künzel W,Kurz CS

    更新日期:1979-01-01 00:00:00

  • Can a low-lying placenta be the risk factor of cervical incompetence? A preliminary study on the relationship between placenta insertion and anatomical status of uterine cervix.

    abstract::An attempt was made to verify the hypothesis that a low-lying placenta may be a factor leading to the dynamic form of cervical incompetence. A vaginal evaluation of the cervix was made in 143 pregnant women who by means of ultrasonographic method were found to have low-lying placentas. In as many as 68 out of the 143 ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000298964

    authors: Uszyński M,Majczyński T,Uszyński W

    更新日期:1985-01-01 00:00:00

  • Patient satisfaction after laparoscopic total or supracervical hysterectomy.

    abstract:BACKGROUND/AIMS:To evaluate patient satisfaction after laparoscopic supracervical (LASH) or total hysterectomy (TLH). METHODS:Retrospective study of patient satisfaction after LASH or TLH. RESULTS:We studied 40 cases of LASH and another 40 of TLH. The age of the patients, marital status, education level and employmen...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000184679

    authors: Kafy S,Al-Sannan B,Kabli N,Tulandi T

    更新日期:2009-01-01 00:00:00

  • Doppler flow velocity waveforms and vasoactive effects of serotonin in human umbilical arteries.

    abstract::The vasoactive effect of serotonin was investigated by in vitro perfusion in human umbilical arteries in which antenatal Doppler ultrasound examination revealed abnormal velocity waveforms. The results were compared to those obtained in preparations from normotensive uncomplicated term pregnancies as well as from pret...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000052885

    authors: Haugen G,Rognerud H

    更新日期:2001-01-01 00:00:00

  • Fimbrio-ovarian relationship in unexplained infertility.

    abstract:INTRODUCTION:The role of defective fimbrio-ovarian relation in cases of unexplained infertility has not been extensively studied. The aim of the study was to assess the role of fimbrio-ovarian relation as an investigative modality in women with unexplained infertility. We also aimed to evaluate the efficacy of superovu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000086004

    authors: Roy KK,Hegde P,Banerjee K,Malhotra N,Nayyar B,Deka D,Kumar S

    更新日期:2005-01-01 00:00:00

  • Cervical partial hydatidiform molar pregnancy.

    abstract:BACKGROUND:Cervical hydatidiform molar pregnancy is an exceedingly rare occurrence that has been reported only twice before. CASE:We report a 25-year-old, G4P1D&C2 woman with a positive pregnancy test and vaginal bleeding. A cervical pregnancy with hydatidiform mole was detected on transvaginal ultrasound and color Do...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000141647

    authors: Aytan H,Caliskan AC,Demirturk F,Koseoglu RD,Acu B

    更新日期:2008-01-01 00:00:00

  • Efficacy of ER-alpha polymorphisms and the intrafollicular IGF system for predicting pregnancy in IVF-ET patients.

    abstract:AIMS:To evaluate the efficacies of the estrogen receptor-alpha (ER-alpha) gene polymorphisms and of the intrafollicular insulin-like growth factor (IGF) system for predicting pregnancy in in vitro fertilization and embryo transfer (IVF-ET) patients. METHODS:A total of 96 patients undergoing IVF-ET were included in thi...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000162104

    authors: Choi YS,Kim SH,Ku SY,Jee BC,Suh CS,Choi YM,Kim JG,Moon SY

    更新日期:2009-01-01 00:00:00