Proliferative activity of human uterine leiomyoma cells as measured by automatic image analysis.

Abstract:

:Proliferative activity of uterine leiomyomas from premenopausal (n = 44) and postmenopausal (n = 12) women was investigated by automatic image analysis on frozen tissue sections using immunohistochemistry with anti-proliferating cell nuclear antigen antibody. The quantitative proliferation index (QPI) in premenopausal leiomyoma cells was significantly (p < 0.025) higher than that in leiomyomas in postmenopausal women. Leiomyomas proliferated most actively during the secretory phase. After the climacterium, leiomyomas showed no proliferative activity in the absence of hormone supply, while combined substitution with estrogen and progestagen considerably increased QPI.

journal_name

Gynecol Obstet Invest

authors

Lamminen S,Rantala I,Helin H,Rorarius M,Tuimala R

doi

10.1159/000292738

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

111-4

issue

2

eissn

0378-7346

issn

1423-002X

journal_volume

34

pub_type

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