Abstract：
:microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we report that microRNA-9 (miR-9) regulates the expression of the Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT-1), one of the most abundant and conserved long non-coding RNAs. Intriguingly, we find that miR-9 targets AGO2-mediated regulation of MALAT1 in the nucleus. Our findings reveal a novel direct regulatory link between two important classes of non-coding RNAs, miRs and lncRNAs, and advance our understanding of microRNA functions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Leucci E,Patella F,Waage J,Holmstrøm K,Lindow M,Porse B,Kauppinen S,Lund AHdoi
10.1038/srep02535subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2535issn
2045-2322pii
srep02535journal_volume
3pub_type
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pub_type： 已发布勘误
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