Abstract:
:Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different environmental stresses depends on the ability of E. faecalis to maintain redox balance via lactate dehydrogenase (LDH). Furthermore, LDH-deficient mutants are less successful than the wild type at colonizing host organs in a murine model of systemic infection. Taken together, our results, as well as those previously published for Staphylococcus aureus (A. R. Richardson, S. J. Libby, and F. C. Fang, Science 319:1672-1676, 2008), identify LDH as an attractive drug target. These drugs may have additional applications, as in the fight against glycopeptide antibiotic-resistant bacteria and even cancer.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rana NF,Sauvageot N,Laplace JM,Bao Y,Nes I,Rincé A,Posteraro B,Sanguinetti M,Hartke Adoi
10.1128/IAI.01299-12subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2662-8issue
8eissn
0019-9567issn
1098-5522pii
IAI.01299-12journal_volume
81pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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