Botulism in metronidazole- treated conventional adult mice challenged orogastrically with spores of Clostridium botulinum type A or B.

abstract：:Urease from ureaplasmas was purified by immunoaffinity chromatography, and the N-terminal amino acid sequence was determined for two of the three subunits. These sequences were used to design primers for a polymerase chain reaction (PCR) that amplified most of the gene coding for one of the subunits. By using a novel ...

journal_title：Infection and immunity

authors： Willoughby JJ,Russell WC,Thirkell D,Burdon MG

更新日期：1991-07-01 00:00:00

abstract：:In an earlier report, we had described the isolation and characterization of autolysis-defective mutants of Staphylococcus aureus (N. Mani, P. Tobin, and R.K. Jayaswal, J. Bacteriol. 175:1493-1499, 1993). In the study reported here, an autolysis-defective mutant showed attenuated virulence in a rat model of experiment...

journal_title：Infection and immunity

authors： Mani N,Baddour LM,Offutt DQ,Vijaranakul U,Nadakavukaren MJ,Jayaswal RK

更新日期：1994-04-01 00:00:00

abstract：:The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in ...

journal_title：Infection and immunity

authors： Lembo A,Kalis C,Kirschning CJ,Mitolo V,Jirillo E,Wagner H,Galanos C,Freudenberg MA

更新日期：2003-10-01 00:00:00

abstract：:Utilization of heme-hemopexin as a source of heme by Haemophilus influenzae type b is dependent on expression by this bacterium of the 100-kDa HxuA protein, which is both present on the bacterial cell surface and released into the culture supernatant (L. D. Cope, R. Yogev, U. Muller-Eberhard, and E. J. Hansen, J. Bact...

journal_title：Infection and immunity

authors： Cope LD,Thomas SE,Hrkal Z,Hansen EJ

更新日期：1998-09-01 00:00:00

abstract：:Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...

journal_title：Infection and immunity

authors： Xue Y,Zhang H,Wang H,Hu J,Du M,Zhu MJ

更新日期：2014-05-01 00:00:00

abstract：:We have isolated full-length cDNAs encoding two distinct types of CuZn superoxide dismutases (SODs) from the filarial nematode parasite Brugia pahangi. The derived amino acid sequences suggested that one class of cDNAs represented a cytoplasmic form of SOD and the second class represented an extracellular (EC) variant...

journal_title：Infection and immunity

authors： Tang L,Ou X,Henkle-Dührsen K,Selkirk ME

更新日期：1994-03-01 00:00:00

abstract：:A virus-specific cell surface antigen(s) was detected on mouse adenovirus-infected cells by the immunofluorescent antibody technique. It was demonstrated in infected cells regardless of the mouse strain or animal species used. It became detectable on the cell surface about 6 h postinfection and was demonstrated in 90%...

journal_title：Infection and immunity

authors： Inada T,Uetake H

更新日期：1977-10-01 00:00:00

abstract：:Two weeks after mice had been infected in the footpad with cells of Nocardia brasiliensis, immunoglobulin and C3 deposits were observed in tissue from the inoculation site. Both immunoglobulin and C3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in w...

journal_title：Infection and immunity

authors： Conde C,Mancilla R,Fresan M,Ortiz-Ortiz L

更新日期：1983-06-01 00:00:00

abstract：:The effects of temperature and treatment with sodium dodecyl sulfate, Tween 20, dithiothreitol, trypsin, or guanidine on the hemagglutinating capacity of six strains of type A influenza virus (A(0)/PR8/34, A(1)/CAME/46, A(2)/J305/57, A(2)/Bethesda/63, A(2)/HK/Aichi/68, and A(2)/HK/80/68), one strain of swine virus (A/...

journal_title：Infection and immunity

authors： Cleeland R,Grunberg E,Prince HN

更新日期：1972-03-01 00:00:00

abstract：:After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important...

journal_title：Infection and immunity

authors： Bassinet L,Fitting C,Housset B,Cavaillon JM,Guiso N

更新日期：2004-09-01 00:00:00

abstract：:Recent studies have shown that probiotics are beneficial in T-cell-mediated inflammatory diseases. The molecular mechanism by which probiotics work remains elusive, but accumulating evidence indicates that probiotics can modulate immune cell responses. Since T cells express receptors for bacterial products or componen...

journal_title：Infection and immunity

authors： Peluso I,Fina D,Caruso R,Stolfi C,Caprioli F,Fantini MC,Caspani G,Grossi E,Di Iorio L,Paone FM,Pallone F,Monteleone G

更新日期：2007-04-01 00:00:00

abstract：:Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two group...

journal_title：Infection and immunity

authors： Pal S,Peterson EM,de La Maza LM

更新日期：2000-08-01 00:00:00

abstract：:The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection u...

journal_title：Infection and immunity

authors： Cyktor JC,Carruthers B,Stromberg P,Flaño E,Pircher H,Turner J

更新日期：2013-04-01 00:00:00

abstract：:A dextranase preparation (AD17) partially purified from a culture liquor of Spicaria violacea strain IFO 6120 significantly inhibited the formation of artifcial dental plaque on a steel wire or on an extracted tooth surface. Changes in the surface morphology of Streptococcus mutans cells due to AD17 action were studie...

journal_title：Infection and immunity

authors： Hamada S,Mizuno J,Murayama Y,Ooshima Y,Masuda N

更新日期：1975-12-01 00:00:00

abstract：:The relationship of catalase, cystinase, and deoxyribonuclease activity to toxinogeny in Corynebacterium diphtheriae was examined. Mutants deficient in each activity were isolated after mutagenization of strain C4 with nitrosoguanidine. All mutants were converted to toxinogeny after lysogenization with beta-converting...

journal_title：Infection and immunity

authors： Groman NB,Dean CK

更新日期：1973-09-01 00:00:00

abstract：:Menstrually associated toxic shock syndrome (TSS) is attributed primarily to the effects of staphylococcal exotoxin toxic shock syndrome toxin 1 (TSST-1). A region of the 194-amino-acid toxin spanning residues 115 through 144 constitutes a biologically active site. Several point mutations in the TSST-1 gene in that re...

journal_title：Infection and immunity

authors： Bonventre PF,Heeg H,Cullen C,Lian CJ

更新日期：1993-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Our laboratory previously reported that LPS-dependent macrophage-derived tumor necrosis factor alpha (TNF-alpha) production could be significantly potentiated by pretreatment with LPS at substimulat...

journal_title：Infection and immunity

authors： Hirohashi N,Morrison DC

更新日期：1996-03-01 00:00:00

abstract：:Microbial heat shock proteins (HSP) are dominant antigens for the host immune response. Because of the high sequence homology between mammalian and microbial HSP, their value as component of a subunit vaccine has been the subject of controversy. Previous work from this laboratory, however, demonstrated for the first t...

journal_title：Infection and immunity

authors： Noll A,AutenriethIB

更新日期：1996-08-01 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections. These bacteria undertake a multistage infection cycle involving invasion of and proliferation within urinary tract epithelial cells, leading to the rupture of the host cell and dispersal of the bacteria, some of which have a highly...

journal_title：Infection and immunity

authors： Iosifidis G,Duggin IG

更新日期：2020-08-19 00:00:00

abstract：:Staphylococcus aureus nasal carriage is a risk factor for infection in humans, particularly in the hospital environment. Attenuation of carriage has proven effective in reducing the prevalence of infection in some high-risk groups. To study staphylococcal factors that influence nasal colonization, a mouse model of S. ...

journal_title：Infection and immunity

authors： Kiser KB,Cantey-Kiser JM,Lee JC

更新日期：1999-10-01 00:00:00

abstract：:Pili have been demonstrated to be the adhesins of Pseudomonas aeruginosa for mouse epidermal cells. The mechanisms of adhesion of P. aeruginosa to mouse epidermal cells was studied by using four mutants derived from a single strain: flagellated and piliated (F+P+), flagellated and nonpiliated (F+P-), nonflagellated an...

journal_title：Infection and immunity

authors： Sato H,Okinaga K

更新日期：1987-08-01 00:00:00

abstract：:Intracellular multiplication of virulent Legionella pneumophila serogroup 1 was inhibited by human monocyte-derived macrophages activated by a glycoprotein extract of Klebsiella pneumoniae, RU 41.740. Macrophage cultures were infected with L. pneumophila in the presence of immune antibodies on day 7 of culture. Extrac...

journal_title：Infection and immunity

authors： Rajagopalan P,Dournon E,Vildé JL,Pocidalo JJ

更新日期：1987-09-01 00:00:00

abstract：:Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...

journal_title：Infection and immunity

authors： Middleton PJ,Petric M,Szymanski MT

更新日期：1975-12-01 00:00:00

abstract：:Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific ep...

journal_title：Infection and immunity

authors： Batteiger BE,Lin PM,Jones RB,Van Der Pol BJ

更新日期：1996-07-01 00:00:00

abstract：:We have previously shown that a Pasteurella multocida cexA mutant (PBA875) was impaired in capsule export and highly attenuated in virulence for mice (J. D. Boyce and B. Adler, Infect. Immun. 68:3463-3468, 2000). In this study we show that immunization with high, but not low, doses of PBA875 can confer significant pro...

journal_title：Infection and immunity

authors： Boyce JD,Adler B

更新日期：2001-03-01 00:00:00

abstract：:The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor ...

journal_title：Infection and immunity

authors： Kato M

更新日期：1974-07-01 00:00:00

abstract：:Nitration of protein A with tetranitromethane incompletely blocks its Fc-binding ability for immunoglobulin G when measured by more sensitive methods of immunoprecipitation and when tested in the enzyme-linked immunosorbent assay. In addition, binding of protein A and blockage by nitration is heterogeneous and depends...

journal_title：Infection and immunity

authors： Sloan GJ,Butler JE

更新日期：1978-08-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by an antiphagocytic polysaccharide capsule whose primary constituent is glucuronoxylomannan (GXM). Three prominent structural features of GXM are single xylosyl and glucuronosyl side chains and O acetylation of the mannose backbone. Isogenic pairs of O-acetyl-positive and O-acety...

journal_title：Infection and immunity

authors： Kozel TR,Levitz SM,Dromer F,Gates MA,Thorkildson P,Janbon G

更新日期：2003-05-01 00:00:00

abstract：:Bovine tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) cDNAs were generated by reverse transcription and then by PCR amplification from lipopolysaccharide (LPS)-stimulated alveolar macrophage RNA. The amplified cDNAs were cloned into pPow and expressed in Escherichia coli DH5 alpha. The expr...

journal_title：Infection and immunity

authors： Yoo HS,Maheswaran SK,Lin G,Townsend EL,Ames TR

更新日期：1995-02-01 00:00:00

abstract：:The mechanism by which recombinant murine gamma interferon (rMuIFN-gamma) and bacterial lipopolysaccharide (LPS) activate mouse resident splenic macrophages to inhibit the intracellular growth of the fungus Histoplasma capsulatum was examined. Growth inhibition depended on L-arginine metabolism. The growth inhibitory ...

journal_title：Infection and immunity

authors： Lane TE,Wu-Hsieh BA,Howard DH

更新日期：1994-05-01 00:00:00