Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.

Abstract:

:The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor from the immune complex.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Kato M

doi

10.1128/IAI.10.1.277-279.1974

subject

Has Abstract

pub_date

1974-07-01 00:00:00

pages

277-9

issue

1

eissn

0019-9567

issn

1098-5522

journal_volume

10

pub_type

杂志文章
  • In vitro response of human T cells to Pseudomonas aeruginosa.

    abstract::Pseudomonas aeruginosa is a gram-negative bacillus that is a major cause of morbidity and mortality in immunosuppressed patients, burn patients, and patients with cystic fibrosis. Although immunity to these bacteria has been associated with serum antibody, more recent evidence suggests that T-cell-mediated immunity ma...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.40.2.670-674.1983

    authors: Porwoll JM,Gebel HM,Rodey GE,Markham RB

    更新日期:1983-05-01 00:00:00

  • Limited T-cell receptor beta-chain diversity of a T-helper cell type 1-like response to Mycobacterium leprae.

    abstract::Delayed-type hypersensitivity (DTH) is the standard measure of T-cell responsiveness to infectious organisms. For leprosy, the Mitsuda reaction, a local immune response to cutaneous challenge with Mycobacterium leprae, is considered to represent a measure of DTH against the pathogen. We analyzed the diversity of the T...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.11.4542-4548.1992

    authors: Uyemura K,Ohmen JD,Grisso CL,Sieling PA,Wyzykowski R,Reisinger DM,Rea TH,Modlin RL

    更新日期:1992-11-01 00:00:00

  • Concomitant loss of conformation and superantigenic activity of staphylococcal enterotoxin B deletion mutant proteins.

    abstract::The T-cell-stimulating activity of staphylococcal enterotoxin B (SEB) is an important factor in the pathogenesis of certain staphylococcal diseases. To investigate the immunologically active domains of the SEB molecule, we have produced truncated fragments of recombinant SEB by C-terminal and N-terminal deletions. The...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.6.2445-2452.1993

    authors: Metzroth B,Marx T,Linnig M,Fleischer B

    更新日期:1993-06-01 00:00:00

  • Mechanism of adherence of Streptococcus mutans to smooth surfaces. II. Nature of the binding site and the adsorption of dextran-levan synthetase enzymes on the cell-wall surface of the streptococcus.

    abstract::The mechanism of adsorption of the Streptococcus mutans enzymes responsible for the synthesis of insoluble dextran-levan to the S. mutans cell-wall binding sites has been studied. Certain characteristics of these binding sites are presented. The adsorption of these enzymes to the cell surface occurred rapidly without ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.9.2.419-429.1974

    authors: Mukasa H,Slade HD

    更新日期:1974-02-01 00:00:00

  • Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis.

    abstract::Four pneumococcal genes (phtA, phtB, phtD, and phtE) encoding a novel family of homologous proteins (32 to 87% identity) were identified from the Streptococcus pneumoniae genomic sequence. These open reading frames were selected as potential vaccine candidates based upon their possession of hydrophobic leader sequence...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.69.2.949-958.2001

    authors: Adamou JE,Heinrichs JH,Erwin AL,Walsh W,Gayle T,Dormitzer M,Dagan R,Brewah YA,Barren P,Lathigra R,Langermann S,Koenig S,Johnson S

    更新日期:2001-02-01 00:00:00

  • Effects of inhibitors of tumoricidal activity upon schistosomulum killing by activated macrophages.

    abstract::Larvae of the helminth parasite Schistosoma mansoni are efficiently killed in vitro by lymphokine-activated macrophages, leading to the hypothesis that these cells may participate in the effector mechanism of protective immunity against schistosomiasis. Larvacidal activity has also been demonstrated in the IC-21 macro...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.55.12.3174-3180.1987

    authors: James SL,Glaven JA

    更新日期:1987-12-01 00:00:00

  • Mechanisms of immunity in typhus infections. IV. Failure of chicken embryo cells in culture to restrict growth of antibody-sensitized Rickettsia prowazeki.

    abstract::Rickettsia prowazeki, pretreated with typhus immune human serum, readily infects, and grows in, chicken embryo cells in culture. This finding is similar to those of previous studies which showed that typhus rickettsiae, pretreated with immune serum, grow in cells of the yolk sac of embryonated hen eggs and in the cell...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.9.3.571-575.1974

    authors: Wisseman CL Jr,Waddell AD,Walsh WT

    更新日期:1974-03-01 00:00:00

  • Hemolytic activity of the Pasteurella haemolytica leukotoxin.

    abstract::A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demo...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.8.3209-3212.1995

    authors: Murphy GL,Whitworth LC,Clinkenbeard KD,Clinkenbeard PA

    更新日期:1995-08-01 00:00:00

  • Tritrichomonas foetus induces apoptotic cell death in bovine vaginal epithelial cells.

    abstract::Tritrichomonas foetus is a serious veterinary pathogen, causing bovine trichomoniasis, a sexually transmitted disease leading to infertility and abortion. T. foetus infects the mucosal surfaces of the reproductive tract. Infection with T. foetus leads to apoptotic cell death of bovine vaginal epithelial cells (BVECs) ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.72.7.4151-4158.2004

    authors: Singh BN,Lucas JJ,Hayes GR,Kumar I,Beach DH,Frajblat M,Gilbert RO,Sommer U,Costello CE

    更新日期:2004-07-01 00:00:00

  • Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model.

    abstract::The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis. In addition to altered physiology, transformed cell lines are composed of a singl...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00740-18

    authors: Ranganathan S,Doucet M,Grassel CL,Delaine-Elias B,Zachos NC,Barry EM

    更新日期:2019-03-25 00:00:00

  • Infection of mice lacking interleukin-7 (IL-7) reveals an unexpected role for IL-7 in the development of the parasite Schistosoma mansoni.

    abstract::A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. H...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.8.4183-4190.1999

    authors: Wolowczuk I,Nutten S,Roye O,Delacre M,Capron M,Murray RM,Trottein F,Auriault C

    更新日期:1999-08-01 00:00:00

  • Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes.

    abstract::Pasteurella (Mannheimia) haemolytica leukotoxin (Lkt) causes cell type- and species-specific effects in ruminant leukocytes. Recent studies indicate that P. haemolytica Lkt binds to bovine CD18, the common subunit of all beta2 integrins. We designed experiments with the following objectives: to identify which member o...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.1.72-79.2000

    authors: Jeyaseelan S,Hsuan SL,Kannan MS,Walcheck B,Wang JF,Kehrli ME,Lally ET,Sieck GC,Maheswaran SK

    更新日期:2000-01-01 00:00:00

  • A Point Mutation in carR Is Involved in the Emergence of Polymyxin B-Sensitive Vibrio cholerae O1 El Tor Biotype by Influencing Gene Transcription.

    abstract::Antimicrobial peptides play an important role in host defense against Vibrio cholerae Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strai...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00080-20

    authors: Samanta P,Mandal RS,Saha RN,Shaw S,Ghosh P,Dutta S,Ghosh A,Imamura D,Morita M,Ohnishi M,Ramamurthy T,Mukhopadhyay AK

    更新日期:2020-04-20 00:00:00

  • Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice.

    abstract::Studies were carried out to determine whether the in vitro capacity of adherent peritoneal cells to replicate herpes simplex virus type 1 (HSV-1) might correlate with the in vivo susceptibility of mice genetically resistant, moderately susceptible, or very susceptible to HSV-1 infection. Unstimulated and proteose pept...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.23.2.432-437.1979

    authors: Lopez C,Dudas G

    更新日期:1979-02-01 00:00:00

  • Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.

    abstract::The unique permissiveness of A/J mouse macrophages for replication of Legionella pneumophila is caused by a deficiency in the Nod-like receptor (NLR) protein and intracellular sensor for L. pneumophila flagellin (Naip5). The signaling pathways and proteins activated by Naip5 sensing in macrophages were investigated. T...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01546-08

    authors: Fortier A,Doiron K,Saleh M,Grinstein S,Gros P

    更新日期:2009-11-01 00:00:00

  • Inhibition of bactericidal activity of anticapsular antibody by nonspecific antibodies reactive with surface-exposed antigenic determinants on Actinobacillus pleuropneumoniae.

    abstract::In an attempt to understand the mechanism of serum resistance in Actinobacillus pleuropneumoniae, in the present study we examined various interactions among the bacterial surface constituents, serum antibodies, and complement. Analysis of swine sera revealed the presence of anticapsular antibodies in convalescent-pha...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.9.3852-3860.1992

    authors: Udeze FA,Kadis S

    更新日期:1992-09-01 00:00:00

  • Genome-wide expression profiling in malaria infection reveals transcriptional changes associated with lethal and nonlethal outcomes.

    abstract::High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of genes in hosts infected in vivo, which result in radically different clinical outcomes. We present an analysis of the g...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.9.6091-6100.2005

    authors: Schaecher K,Kumar S,Yadava A,Vahey M,Ockenhouse CF

    更新日期:2005-09-01 00:00:00

  • Interaction of staphylococcal exfoliative toxin with concanavalin A.

    abstract::Treatment of mouse embryo fibroblasts (MEF) grown in vitro with purified staphylococcal exfoliative toxin (ET) increased the concanavalin A (Con A) agglutinability of MEF 3.5-fold over control cells. Possible explanations for this phenomenon were investigated. ET lacked proteolytic activity on denatured casein. Con A,...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.10.6.1260-1265.1974

    authors: Rogolsky M,Wiley BB,Keyhani M,Glasgow LA

    更新日期:1974-12-01 00:00:00

  • Occurrence of quinovosamine in lipopolysaccharides of Brucella species.

    abstract::Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.9.4.772-774.1974

    authors: Bowser DV,Wheat RW,Foster JW,Leong D

    更新日期:1974-04-01 00:00:00

  • Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis.

    abstract::A mutual symbiotic enhancement of growth of Porphyromonas gingivalis and Treponema denticola is described in this report. Brain heart infusion broth supplemented with vitamin K did not support the individual growth of P. gingivalis or T. denticola. However, when inoculated as a mixture, both bacterial species did grow...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.12.5298-5301.1992

    authors: Grenier D

    更新日期:1992-12-01 00:00:00

  • Anti-Pneumococcal Capsular Polysaccharide Antibody Response and CD5 B Lymphocyte Subsets.

    abstract::The role of CD19(+) CD5(+) and CD19(+) CD5(-) B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19(+) CD5(+) and CD19(+) CD5(-) cell populations in the serotype-specific antibody response to caps-P...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00068-15

    authors: Moens L,Verbinnen B,Covens K,Wuyts G,Johnson M,Roalfe L,Goldblatt D,Meyts I,Bossuyt X

    更新日期:2015-07-01 00:00:00

  • Experimental hematogenous candidiasis caused by Candida krusei and Candida albicans: species differences in pathogenicity.

    abstract::Hematogenous infections caused by Candida krusei have been noted with increasing frequency, particularly in cancer patients receiving prophylaxis with antifungal triazoles. Progress in understanding the pathogenesis of this emerging infection has been limited by the lack of an animal model. We developed a CF1 mouse in...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.4.1268-1271.1993

    authors: Anaissie E,Hachem R,K-Tin-U C,Stephens LC,Bodey GP

    更新日期:1993-04-01 00:00:00

  • The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.

    abstract::A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.72.9.5483-5486.2004

    authors: Frota CC,Papavinasasundaram KG,Davis EO,Colston MJ

    更新日期:2004-09-01 00:00:00

  • Failure of CD4 T Cell-Deficient Hosts To Control Chronic Nontyphoidal Salmonella Infection Leads to Exacerbated Inflammation, Chronic Anemia, and Altered Myelopoiesis.

    abstract::Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella est...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00417-20

    authors: Loomis WP,Delaney MA,Johnson ML,Cookson BT

    更新日期:2020-12-15 00:00:00

  • Th1-directing adjuvants increase the immunogenicity of oligosaccharide-protein conjugate vaccines related to Streptococcus pneumoniae type 3.

    abstract::Oligosaccharide (OS)-protein conjugates are promising candidate vaccines against encapsulated bacteria, such as Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae. Although the effects of several variables such as OS chain length and protein carrier have been studied, little is known about th...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.12.6915-6920.2003

    authors: Lefeber DJ,Benaissa-Trouw B,Vliegenthart JF,Kamerling JP,Jansen WT,Kraaijeveld K,Snippe H

    更新日期:2003-12-01 00:00:00

  • Role of host factors in the pathogenesis of Salmonella-associated arthritis in rats.

    abstract::To evaluate the roles of the infectious agent and the host in the pathogensis of Salmonella-associated arthritis (SAA), 1O(3) to 10(6) heat-killed Salmonella enteritidis were injected directly into involved carpal joints in normal and actively immunized rats and in hosts adoptively immunized by the intravenous transfe...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.13.4.1155-1160.1976

    authors: Volkman A,Collins FM

    更新日期:1976-04-01 00:00:00

  • Enzyme-linked immunosorbent assay for quantitating the humoral immune response to the colonization factor antigen of enterotoxigenic Escherichia coli.

    abstract::The enzyme-linked immunosorbent assay technique was used to quantitate, in milligrams per milliliter, anti-colonization factor antigen/I (CFA/I) immunoglobulin G (IgG) in acute- and convalescent-phase sera of individuals who experienced diarrhea associated with CFA/I-positive enterotoxigenic Escherichia coli. Purified...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.27.2.525-531.1980

    authors: Clegg S,Evans DG,Evans DJ Jr

    更新日期:1980-02-01 00:00:00

  • Complicated urinary tract infection is associated with uroepithelial expression of proinflammatory protein S100A8.

    abstract::F344 rats chronically infected with Ureaplasma parvum develop two distinct profiles: asymptomatic urinary tract infection (UTI) and UTI complicated by struvite urolithiasis. To identify factors that affect disease outcome, we characterized the temporal host immune response during infection by histopathologic analysis ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00458-09

    authors: Reyes L,Alvarez S,Allam A,Reinhard M,Brown MB

    更新日期:2009-10-01 00:00:00

  • Biogenesis of Leishmania major-harboring vacuoles in murine dendritic cells.

    abstract::In mammalian hosts, Leishmania sp. parasites are obligatory intracellular organisms that invade macrophages and dendritic cells (DC), where they reside in endocytic organelles termed parasitophorous vacuoles (PV). Most of the present knowledge of the characteristics of PV harboring Leishmania sp. is derived from studi...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.74.2.1305-1312.2006

    authors: Körner U,Fuss V,Steigerwald J,Moll H

    更新日期:2006-02-01 00:00:00

  • Location of feline leukemia-sarcoma group-specific antigen in infected human tissue culture cells.

    abstract::Feline leukemia-sarcoma group-specific antigens were located in human embryo cells infected with feline leukemia and feline sarcoma viruses. This was done by using the fluorescent-antibody and enzyme-labeled antibody techniques at both light and electron microscopic levels. The antigens were found to be exclusively in...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.5.3.400-405.1972

    authors: Ubertini TR

    更新日期:1972-03-01 00:00:00