Abstract:
:Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two groups of mice were shown to be similarly susceptible to an intranasal infection with these microorganisms. In conclusion, the Nramp1 gene does not appear to play a major role in the regulation of the susceptibility of mice to a chlamydial infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Pal S,Peterson EM,de La Maza LMdoi
10.1128/iai.68.8.4831-4833.2000keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
4831-3issue
8eissn
0019-9567issn
1098-5522journal_volume
68pub_type
杂志文章abstract::Vibrio cholerae V86 El Tor Inaba caused experimental cholera in germfree ICR suckling mice. Sucklings born of gnotobiotic mothers monoassociated with the same strain were completely protected against live oral homologous challenge. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.1.296-298.1981
更新日期:1981-10-01 00:00:00
abstract::Cathepsin G (CatG) is a serine protease found in the azurophilic granules of monocytes that is known to have antimicrobial properties, but its role in Mycobacterium tuberculosis infection is unknown. We found that M. tuberculosis infection of human THP-1 monocytic cells induced the down-regulation of CatG mRNA express...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5712-5721.2004
更新日期:2004-10-01 00:00:00
abstract::Natural heterogeneity in the structure of the lipid A portion of lipopolysaccharide (LPS) produces differential effects on the innate immune response. Gram-negative bacterial species produce LPS structures that differ from the classic endotoxic LPS structures. These differences include hypoacylation and hypophosphoryl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01150-12
更新日期:2013-09-01 00:00:00
abstract::While gamma/delta T cells are involved in host defense and immunopathology in a variety of infectious diseases, their precise role is not yet clearly defined. In the absence of gamma/delta T cells, mice die after infection with a dose of Listeria monocytogenes that is not lethal in immunologically intact animals. Morb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7213-7223.2001
更新日期:2001-12-01 00:00:00
abstract::Oxygen consumption by Treponema pallidum was observed to be glucose dependent. Treponemes consumed O2 to a low dissolved O2 concentration of 0.01 mumol of O2 per ml when respiration ceased. A fermentative degradation of glucose occurred during the maintenance of treponemes at 0.01 mumol of O2 per ml. Although the init...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.3.992-997.1981
更新日期:1981-03-01 00:00:00
abstract::Lipopolysaccharides (LPS), either in the free form or complexed to CD14, a LPS receptor, are elicitors of the immune system. Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock. Since optimal protection requires administration of Lf prior to lethal doses of LPS, we hypothesized that i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6519-6525.2000
更新日期:2000-12-01 00:00:00
abstract::Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides, such as the human cathelicidin antimicrobial peptide 18 (hCAP18)/LL-37, by vitamin D in bronchial epithelial cells requir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06224-11
更新日期:2012-12-01 00:00:00
abstract::Classical and El Tor strains of Vibrio cholerae were examined for production of bacteriophage or bacteriophage-related material by electron microscopy of mitomycin C-induced cultures. The strains were also tested for pathogenicity by using the ligated ileal loops of adult rabbits. Of the 27 strains tested, 25 showed a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.1.4.417-420.1970
更新日期:1970-04-01 00:00:00
abstract::Ehrlichia chaffeensis, a tick-borne rickettsial organism, causes the disease human monocytic ehrlichiosis. The pathogen also causes disease in several other vertebrates, including dogs and deer. In this study, we assessed two clonally purified E. chaffeensis mutants with insertions within the genes Ech_0379 and Ech_06...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00487-15
更新日期:2015-07-01 00:00:00
abstract::The concept that relates low virulence of certain alphaviruses to low viremia and efficient vascular clearance of virus was tested in guinea pigs. Previously published studies with hamsters suggested that virulent strains maintain high viremias primarily because they are cleared inefficiently from the blood. In the pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.17.2.356-360.1977
更新日期:1977-08-01 00:00:00
abstract::In malarial infections of primates, the spleen has been shown to modulate parasite antigen expression on the surfaces of infected erythrocytes. The processes affected include cytoadherence, which is central to the pathophysiology of severe falciparum malaria, and the related phenomenon of rosette formation. In this st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.6.2225-2228.1992
更新日期:1992-06-01 00:00:00
abstract::Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5085-5091.1996
更新日期:1996-12-01 00:00:00
abstract::Monolayer cultures of LLC-MK2 rhesus monkey kidney cells become persistently infected with simian virus 40 after infection at input multiplicities of 100, 10, or 1 plaque-forming unit per cell. After 3 weeks, all cells of the cultures infected at a multiplicity of 1 plaque-forming unit per cell produced the simian vir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.3.868-871.1977
更新日期:1977-12-01 00:00:00
abstract::Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2247-2252.2003
更新日期:2003-04-01 00:00:00
abstract::Human peripheral blood monocytes become apoptotic following phagocytosis of Staphylococcus aureus. In this study, we investigated the mechanisms involved in this phenomenon. Cells exposed to bacteria were examined for the surface expression of Fas and Fas ligand (FasL). The level of soluble form of FasL was also measu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1287-1297.2001
更新日期:2001-03-01 00:00:00
abstract::Activation of macrophages was assessed in strains of mice inoculated intraperitoneally with 1,000 times the 50% lethal dose of Rickettsia akari. Macrophages from mice resistant to R. akari infection (C3H/HeN, C57BL/10J, and BALB/cN) were nonspecifically tumoricidal 2 to 4 days after rickettsial inoculation. Moreover, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.3.1096-1101.1982
更新日期:1982-06-01 00:00:00
abstract::We have demonstrated that possession of the gene for thermostable direct hemolysin-related hemolysin (trh) coincides with the presence of the urease gene among clinical Vibrio parahaemolyticus strains and that the location of the two genes are in close proximity on the chromosome. Here, we cloned and sequenced the 15,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5742-5748.2000
更新日期:2000-10-01 00:00:00
abstract::Lung dendritic cells were identified by immunohistochemistry in lung tissue sections from C57BL/6 mice. Following isolation from the lungs using CD11c magnetic beads, the flow cytometric analysis of I-A(b+) and CD11c(+) cells indicated a mixed population of dendritic cells at different stages of maturation, with most ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.2.1127-1133.2001
更新日期:2001-02-01 00:00:00
abstract::Cell walls from Streptococcus mutans were prepared by conventional technique and subjected to a series of extraction procedures involving classical protein solvents. The extracted walls contained several non-peptidoglycan amino acids and were also amenable to radiolabeling with [125I]sodium iodide and chloramine T. Th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.28.1.118-126.1980
更新日期:1980-04-01 00:00:00
abstract::Six strains of Rickettsia rickettsii from Montana and North Carolina were examined in an effort to identify rickettsial constituents associated with virulence. Fever responses, scrotal reactions, and mortalities of male guinea pigs inoculated intraperitoneally with 1,000 PFU of rickettsial strains revealed that the tw...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.3.559-564.1984
更新日期:1984-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00718-20
更新日期:2021-01-19 00:00:00
abstract::Streptococcus suis is one of the most important pathogens affecting the swine industry and is also an emerging zoonotic agent for humans. Two-component signaling systems (TCSs) play important roles in the adaptation of pathogenic bacteria to host environments. In this study, we identified a novel TCS, named TCS09HKRR,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00377-19
更新日期:2019-08-21 00:00:00
abstract::The humoral and cell-mediated immune responses of murine lymphocytes exposed to lead in vivo and in vitro were investigated. In vivo Pb was administered via the drinking water (0 to 10 mM) for 1 to 10 weeks. In vivo exposure of the mice to Pb did not alter significantly their plaque-forming cell response to sheep eryt...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.136-143.1981
更新日期:1981-01-01 00:00:00
abstract::We attempted to induce experimental arthritis in rats by systematically testing the effect of Yersinia infections in five strains of rats, using the intragastric, intraperitoneal, and intravenous routes of inoculation. We observed that Lewis rats which were given 10(4) to 10(5) Yersinia enterocolitica WA organisms via...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.3.721-726.1987
更新日期:1987-03-01 00:00:00
abstract::Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.992-995.1989
更新日期:1989-03-01 00:00:00
abstract::Periodontitis is the inflammatory response in periodontal tissues elicited by bacterial colonization in periodontal pockets. In this response, pocket epithelial cells are the first cells to come into contact with bacteria. To elucidate this mechanism, we determined the adherence of the periodontopathic bacterium Eiken...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.1.384-394.1999
更新日期:1999-01-01 00:00:00
abstract::In this study, we examined the binding of Candida albicans synchronized yeast-phase cells to plastic, immobilized amino acids and bovine serum albumin (BSA) and quantified the binding by using an XTT tetrazolium salt assay and absorbance determination. Our results show that C. albicans binds efficiently and specifical...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.1.140-144.1998
更新日期:1998-01-01 00:00:00
abstract::Uropathogenic Escherichia coli (UPEC) is responsible for the majority of uncomplicated urinary tract infections (UTI) and represents the most common bacterial infection in adults. UPEC utilizes a wide range of virulence factors to colonize the host, including the novel repeat-in-toxin (RTX) protein TosA, which is spec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05713-11
更新日期:2012-02-01 00:00:00
abstract::Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific ep...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2839-2841.1996
更新日期:1996-07-01 00:00:00