Interleukin-6 (IL-6) and IL-8 are induced in human oral epithelial cells in response to exposure to periodontopathic Eikenella corrodens.

abstract：:Vibrio cholerae, the pathogen that causes cholera, also survives in aqueous reservoirs, probably in the form of biofilms. Quorum sensing negatively regulates V. cholerae biofilm formation through HapR, whose expression is induced at a high cell density. In this study, we show that the concentration of the quorum-sensi...

journal_title：Infection and immunity

authors： Liu Z,Stirling FR,Zhu J

更新日期：2007-01-01 00:00:00

abstract：:Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked. Many pathogens have acquired the ability to sequester complement regulators from host plasma to evade complement attack. We describe here how Streptococcus pneumoniae adopts a st...

journal_title：Infection and immunity

authors： Haleem KS,Ali YM,Yesilkaya H,Kohler T,Hammerschmidt S,Andrew PW,Schwaeble WJ,Lynch NJ

更新日期：2018-12-19 00:00:00

abstract：:The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificit...

journal_title：Infection and immunity

authors： Callaghan MJ,Jolley KA,Maiden MC

更新日期：2006-09-01 00:00:00

abstract：:Thirty-two trachoma strains were simultaneously titrated in the yolk sac of embryonated chicken eggs and in HeLa 229 cells pretreated with diethylaminoethyl-dextran to determine the relative sensitivity of the two culture systems for detection of the infection. The strains tested were both yolk sac- and HeLa cell-esta...

journal_title：Infection and immunity

authors： Kuo CC,Wang SP,Grayston JT

更新日期：1975-11-01 00:00:00

abstract：:Legionella pneumophila is a gram-negative facultative intracellular parasite of macrophages. Although L. pneumophila is the causative agent of a severe pneumonia known as Legionnaires' disease, it is likely that most infections caused by this organism are cleared by the host innate immune system. It is predicted that ...

journal_title：Infection and immunity

authors： Archer KA,Roy CR

更新日期：2006-06-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO), a tryptophan-degrading enzyme, is inducible by various interferons (IFNs). IDO-mediated tryptophan degradation, but not the formation of IDO-catalyzed tryptophan metabolites, has been suggested as a mechanism for the antiparasitic action of IFN-gamma. To determine whether the IFN-gam...

journal_title：Infection and immunity

authors： Habara-Ohkubo A,Shirahata T,Takikawa O,Yoshida R

更新日期：1993-05-01 00:00:00

abstract：:The protective efficacy of Mycobacterium bovis BCG can be markedly augmented by stable integration of Mycobacterium tuberculosis genomic region RD1. BCG complemented with RD1 (BCG::RD1) encodes nine additional proteins. Among them, 10-kDa culture filtrate protein (CFP-10) and ESAT-6 (6-kDa early secreted antigenic tar...

journal_title：Infection and immunity

authors： Demangel C,Brodin P,Cockle PJ,Brosch R,Majlessi L,Leclerc C,Cole ST

更新日期：2004-04-01 00:00:00

abstract：:An extracellular cytolysin produced by Vibrio metschnikovii was purified by acid precipitation, phenyl-Sepharose CL-4B chromatography, and rechromatography on a phenyl-Sepharose CL-4B column and high-performance liquid chromatography on a Mono Q (anion-exchange) column. The purified cytolysin had a molecular weight of...

journal_title：Infection and immunity

authors： Miyake M,Honda T,Miwatani T

更新日期：1988-04-01 00:00:00

abstract：:Previous data from our laboratory suggest that the transitional epithelium of the urinary bladder secretes and binds to its surface a glycosaminoglycan. The presence of this substance at the bladder surface markedly reduces the ability of microorganisms to adhere to the mucosa. Furthermore, this glycosaminoglycan can ...

journal_title：Infection and immunity

authors： Parsons CL,Pollen JJ,Anwar H,Stauffer C,Schmidt JD

更新日期：1980-03-01 00:00:00

abstract：:Murine cerebral malaria (CM) induced by Plasmodium berghei ANKA kills susceptible mice within 24 to 48 h of onset of symptoms and is characterized by the production of inflammatory cytokines in the brain. C57BL/6J mice are sensitive to lethal CM, while A/J mice are resistant. These strains of mice were immunized with ...

journal_title：Infection and immunity

authors： Jennings VM,Lal AA,Hunter RL

更新日期：1998-12-01 00:00:00

abstract：:Attention has recently been focused on immunoglobulin A1 (IgA1) protease production as a possible virulence factor of bacteria implicated in meningitis and gonorrhea. This report demonstrates that suspected principal etiological agents in destructive periodontal disease include bacteria capable of degrading IgA1, IgA2...

journal_title：Infection and immunity

authors： Kilian M

更新日期：1981-12-01 00:00:00

abstract：:One rabbit pathogenic Escherichia coli strain, belonging to serogroup O103, harbors a self-transferable 117-kb plasmid (pREC-1) encoding resistance to several antibiotics. The role of this R plasmid in the colonization of the digestive tract in specific-pathogen-free (E. coli O103-free) rabbits was studied. Five-week-...

journal_title：Infection and immunity

authors： Reynaud A,Federighi M,Licois D,Guillot JF,Joly B

更新日期：1991-06-01 00:00:00

abstract：:Previously, we isolated a high-molecular-weight immunogenic polysaccharide (designated PS) from Pseudomonas aeruginosa immunotype 1 (IT-1). The method which we used was modified to permit the isolation of a similar PS from P. aeruginosa IT-2. This antigen was composed primarily of carbohydrate, had a complex monosacch...

journal_title：Infection and immunity

authors： Pier GB,Sidberry HF,Sadoff JC

更新日期：1981-11-01 00:00:00

abstract：:Cronobacter sakazakii is an opportunistic pathogen that causes neonatal meningitis and necrotizing enterocolitis. Its interaction with intestinal epithelium is important in the pathogenesis of enteric infections. In this study, we investigated the involvement of the inv gene in the virulence of C. sakazakii ATCC 29544...

journal_title：Infection and immunity

authors： Chandrapala D,Kim K,Choi Y,Senevirathne A,Kang DH,Ryu S,Kim KP

更新日期：2014-05-01 00:00:00

abstract：:Two Escherichia coli strains (B/M 369 and C-35) belonging to enteropathogenic serogroup O86 were isolated from patients with infantile diarrhea and studied with respect to their cellular adherence properties. Both strains exhibited adherence (Ad+) to HEp-2 and HeLa cell monolayers in vitro and expressed mannose-resist...

journal_title：Infection and immunity

authors： Pal R,Ghose AC

更新日期：1990-04-01 00:00:00

abstract：:The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined with an in vivo model of experimental hematogenous E. coli K1 meningitis and an in vitro model of the blood-brain barrier....

journal_title：Infection and immunity

authors： Hoffman JA,Wass C,Stins MF,Kim KS

更新日期：1999-07-01 00:00:00

abstract：:Legionella pneumophila organisms are able to infect and multiply within the ciliated protozoan Tetrahymena pyriformis. This ability may be associated with virulence, because an attenuated strain of L. pneumophila fails to multiply within this protozoan, whereas a virulent strain increases 10,000-fold in number when co...

journal_title：Infection and immunity

authors： Fields BS,Barbaree JM,Shotts EB Jr,Feeley JC,Morrill WE,Sanden GN,Dykstra MJ

更新日期：1986-09-01 00:00:00

abstract：:Production of interleukin-10 (IL-10) by C57BL/6 mice following infection with Borrelia burgdorferi has been proposed as a mechanism whereby resistance to the development of experimental Lyme arthritis is maintained. In the current study, we sought to determine the role of IL-10 during infection of arthritis- and cardi...

journal_title：Infection and immunity

authors： Brown CR,Lai AY,Callen ST,Blaho VA,Hughes JM,Mitchell WJ

更新日期：2008-12-01 00:00:00

abstract：:Mouse peritoneal macrophages were successfully infected with two strains of Junin virus producing high titers with no apparent cell damage. Infected cultures survived longer than noninfected cultures. The pattern of virus release suggested a persistent infection. Virus replication was delayed in macrophages from mice ...

journal_title：Infection and immunity

authors： González PH,Lampuri JS,Coto CE,Laguens RP

更新日期：1982-01-01 00:00:00

abstract：:The purpose of these experiments was to study the early response of mouse foot pads to Mycobacterium leprae. To accomplish this, mice were inoculated in both foot pads with large and small numbers of organisms. The animals were sacrificed at intervals from 2 hr to 27 days after inoculation. The microscopical results, ...

journal_title：Infection and immunity

authors： Evans MJ,Newton HE,Levy L

更新日期：1973-01-01 00:00:00

abstract：:HbhA of Mycobacterium tuberculosis is a multifunctional binding protein, binding to both sulfated sugars such as heparin and to human complement component C3. HbhA may therefore interact with host molecules and/or host cells during M. tuberculosis infection and play a role in the pathogenesis of this bacterium. The pu...

journal_title：Infection and immunity

authors： Mueller-Ortiz SL,Sepulveda E,Olsen MR,Jagannath C,Wanger AR,Norris SJ

更新日期：2002-12-01 00:00:00

abstract：:One of the hallmarks of Pseudomonas aeruginosa infection in cystic fibrosis (CF) patients is very-high-cell-density (HCD) replication in the lung, allowing this bacterium to induce virulence controlled by the quorum-sensing systems. However, the nutrient sources sustaining HCD replication in this chronic infection are...

journal_title：Infection and immunity

authors： Son MS,Matthews WJ Jr,Kang Y,Nguyen DT,Hoang TT

更新日期：2007-11-01 00:00:00

abstract：:To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse macrophages infected with a virulent strain containing an 85-kb plasmid and expressing VapA (103+), its avirulent plasmid-cured d...

journal_title：Infection and immunity

authors： Giguère S,Prescott JF

更新日期：1998-05-01 00:00:00

abstract：:We examined the way the major outer membrane protein OmpA of Salmonella enterica serovar Typhimurium is recognized by the mouse immune system, by raising a panel of 12 monoclonal antibodies (MAbs) against this protein. Interaction between OmpA and these MAbs is competitively inhibited with several-hundredfold dilution...

journal_title：Infection and immunity

authors： Singh SP,Williams YU,Miller S,Nikaido H

更新日期：2003-07-01 00:00:00

abstract：:We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx...

journal_title：Infection and immunity

authors： O'Connell CM,AbdelRahman YM,Green E,Darville HK,Saira K,Smith B,Darville T,Scurlock AM,Meyer CR,Belland RJ

更新日期：2011-03-01 00:00:00

abstract：:Human gingival fibroblasts were exposed in culture to cell extracts of different black-pigmented Bacteroides species, and their growth was monitored by determining thymidine uptake and counting cells. Of the Bacteroides species tested (B. gingivalis, B. asaccharolyticus, and B. intermedius), B. gingivalis gave the ext...

journal_title：Infection and immunity

authors： Larjava H,Uitto VJ,Eerola E,Haapasalo M

更新日期：1987-01-01 00:00:00

abstract：:Cryptococcus neoformans is a facultative intracellular opportunistic pathogen and the leading cause of fungal meningitis in humans. In the absence of a protective cellular immune response, the inhalation of C. neoformans cells or spores results in pulmonary infection. C. neoformans cells produce a polysaccharide capsu...

journal_title：Infection and immunity

authors： Geunes-Boyer S,Oliver TN,Janbon G,Lodge JK,Heitman J,Perfect JR,Wright JR

更新日期：2009-07-01 00:00:00

abstract：:We have examined the ability of peptidoglycan (PepG) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 in whole human blood and identified the cellular origins of these cytokines. Both PepG and LTA induced t...

journal_title：Infection and immunity

authors： Wang JE,Jørgensen PF,Almlöf M,Thiemermann C,Foster SJ,Aasen AO,Solberg R

更新日期：2000-07-01 00:00:00

abstract：:Escherichia coli F-18, isolated from the feces of a healthy human in 1977, is an excellent colonizer of the streptomycin-treated mouse large intestine and displays normal motility and chemotaxis ability. A chemotaxis-defective derivative of E. coli F-18, E, coli F-18 CheA-, and a nonflagellated derivative, E. coli F-1...

journal_title：Infection and immunity

authors： McCormick BA,Laux DC,Cohen PS

更新日期：1990-09-01 00:00:00

abstract：:We investigated a possible cause-and-effect relationship between sensitization against Actinomyces viscosus Nyl and destructive periodontal disease in RIC-Sprague-Dawley rats. Germfree rats (66) were either immunized with A. viscosus Nyl (day 20) or orally infected with A. viscosus Nyl (days 38 and 39) or both. We mea...

journal_title：Infection and immunity

authors： Burckhardt JJ,Gaegauf-Zollinger R,Schmid R,Guggenheim B

更新日期：1981-03-01 00:00:00