Clinical impact of 8 prospective, randomized, multicenter glaucoma trials.

abstract：PURPOSE:To clarify the mechanism by which bunazosin hydrochloride (BZ), a selective alpha1-adrenoceptor antagonist, increases uveoscleral outflow. METHODS:The effects of BZ on matrix metalloproteinase (MMP) activities in cultured monkey ciliary muscle cells, and on phenylephrine hydrochloride-induced constriction in b...

journal_title：Journal of glaucoma

authors： Akaishi T,Takagi Y,Matsugi T,Ishida N,Hara H,Kashiwagi K

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To report a simple technique for removal of malpositioned Ex-PRESS miniature glaucoma filtration device. PATIENT AND METHODS:A patient who underwent removal of a malpositioned Ex-PRESS shunt from the right eye with wound revision. RESULTS:Description of step-by-step technique for removal of the Ex-PRESS shunt...

journal_title：Journal of glaucoma

authors： Khouri AS,Khan MN,Fechtner RD,Vold SD

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...

journal_title：Journal of glaucoma

authors： MK-507 Clinical Study Group.

更新日期：1995-02-01 00:00:00

abstract：AIMS:An observational study to determine the safety and efficacy of filtering surgery employing a microlumen aqueous drainage device (InnFocus MicroShunt), used intraoperatively with Mitomycin C, implanted alone or in combination with phacoemulsification. MATERIALS AND METHODS:Single-site, prospective, nonrandomized s...

journal_title：Journal of glaucoma

authors： Batlle JF,Fantes F,Riss I,Pinchuk L,Alburquerque R,Kato YP,Arrieta E,Peralta AC,Palmberg P,Parrish RK 2nd,Weber BA,Parel JM

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). PATIENTS AND METHODS:In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG att...

journal_title：Journal of glaucoma

authors： Chien KH,Lu DW,Chen YH,Cheng JH,Chen JT

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:To find the dropout rate and identify the clinical characteristics of patients who drop out in the first year of follow-up from a glaucoma clinic. DESIGN:Descriptive hospital-based study at a tertiary hospital eye department. METHODS:Clinical characteristics of consecutive patients newly diagnosed with glauco...

journal_title：Journal of glaucoma

authors： Ashaye AO,Adeoye AO

更新日期：2008-04-01 00:00:00

abstract：PRCIS:Use of toric intraocular lenses is a reasonable option for better visual outcomes when a combined minimally invasive glaucoma surgery (MIGS) and cataract surgery is performed in eyes with corneal astigmatism. PURPOSE:To assess the efficacy of toric intraocular lenses (IOLs) in combined cataract and MIGS, visual ...

journal_title：Journal of glaucoma

authors： Ichioka S,Manabe K,Tsutsui A,Takai Y,Tanito M

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Axenfeld-Rieger syndrome is a genetically heterogeneous, autosomal dominant disorder that is characterized by anterior segment defects, glaucoma, and extraocular anomalies. This study examined the two genes known to cause Rieger syndrome, PITX2 and FOXC1, for mutations in five Brazilian families with Axenfeld-R...

journal_title：Journal of glaucoma

authors： Borges AS,Susanna R Jr,Carani JC,Betinjane AJ,Alward WL,Stone EM,Sheffield VC,Nishimura DY

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:To assess the comparative efficacy and safety of primary deep sclerectomy (DS) augmented with subconjunctival Bevacizumab and intraoperative Mitomycin C (MMC). METHODS:Retrospective, comparative case-control series of consecutive primary DS between January 2008 and December 2010. Seventy-five eyes of 73 patien...

journal_title：Journal of glaucoma

authors： Anand N,Bong C

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics and systemic diseases in a well-defined population. METHODS:The Thessaloniki Eye study is a cross-sectional population-based study of chronic eye diseases in Thessaloniki, Greece. Participants with PEX we...

journal_title：Journal of glaucoma

authors： Anastasopoulos E,Topouzis F,Wilson MR,Harris A,Pappas T,Yu F,Koskosas A,Founti P,Coleman AL

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To classify the appearance of the optic disc seen on fundus photographs of healthy subjects and patients with or suspected glaucoma whose diagnosis was based upon visual fields (VFs) and spectral-domain optical coherence tomography (sdOCT) results. PATIENTS AND METHODS:One eye of 100 patients with or suspected...

journal_title：Journal of glaucoma

authors： Alhadeff PA,De Moraes CG,Chen M,Raza AS,Ritch R,Hood DC

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The authors describe the first case of delayed antimetabolite-related corneal epithelial toxicity after trabeculectomy and its successful treatment with limbal stem cell transplantation. METHODS:A 73-year-old woman underwent trabeculectomy with intraoperative mitomycin C. After surgery she received six 5-mg in...

journal_title：Journal of glaucoma

authors： Manche EE,Afshari MA,Singh K

更新日期：1998-08-01 00:00:00

abstract：INTRODUCTION:Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described. METHODS:We present a case of...

journal_title：Journal of glaucoma

authors： Ichhpujani P,Thakur S,Kumar S,Singh RB

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....

journal_title：Journal of glaucoma

authors： Hosoda M,Yamabayashi S,Furuta M,Tsukahara S

更新日期：1995-06-01 00:00:00

abstract：:PRéCIS:: Micropulse trans-scleral cyclophotocoagulation (TSCPC) is an effective and safe IOP-lowering treatment for patients with primary or secondary glaucoma. PURPOSE:To investigate the 1-year and 2-year effect on intraocular pressure (IOP) and safety profile of micropulse TSCPC in patients with glaucoma. METHODS:...

journal_title：Journal of glaucoma

authors： de Crom RMPC,Slangen CGMM,Kujovic-Aleksov S,Webers CAB,Berendschot TTJM,Beckers HJM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS:This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randoml...

journal_title：Journal of glaucoma

authors： Chihara E,Dong J,Ochiai H,Hamada S

更新日期：2002-04-01 00:00:00

abstract：:The recent advent of in vivo two-photon microscopy has allowed the repeat imaging of cortical structures at microscopic resolution within intact brains. Recent data obtained using this imaging technique shows that dendritic spines, the postsynaptic sites of the majority of excitatory synapses in the central nervous sy...

journal_title：Journal of glaucoma

authors： Majewska AK

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Latanoprost, travoprost, and bimatoprost are prostaglandin or prostamide-type ocular hypotensive medications, all of which are effective and safe for lowering intraocular pressure (IOP). Most studies with these types of drugs have included patients mainly from European or white ethnic backgrounds; however, some...

journal_title：Journal of glaucoma

authors： Birt CM,Buys YM,Ahmed II,Trope GE,Toronto Area Glaucoma Society.

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To evaluate circulatory melatonin levels by assessing nocturnal urinary excretion of 6-sulfatoxymelatonin (aMT6s) in patients with primary open-angle glaucoma (POAG) and to compare the high-tension group and the low-tension group. METHODS:This study included 80 eyes of 41 POAG patients and 87 eyes of 44 contro...

journal_title：Journal of glaucoma

authors： Kim JY,Jeong AR,Chin HS,Kim NR

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the proportion of patients in the US population who are receiving long-term intraocular pressure (IOP)-lowering medication, but, deny having a diagnosis of glaucoma or elevated IOP. MATERIALS AND METHODS:The National Health and Nutrition Examination Survey (NHANES) is...

journal_title：Journal of glaucoma

authors： Lowry EA,Mansberger SL

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To determine whether a structure-function model developed for normal age-related losses of retinal ganglion cells also models the retinal ganglion cell losses in glaucomatous optic neuropathy. METHODS:The model to relate age-related loss of retinal nerve fiber layer thickness and reduced sensitivity for standa...

journal_title：Journal of glaucoma

authors： Wheat JL,Rangaswamy NV,Harwerth RS

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF THE STUDY:The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentr...

journal_title：Journal of glaucoma

authors： Holló G

更新日期：2017-05-01 00:00:00

abstract：PRECIS:The association between primary open-angle glaucoma (POAG) and subsequent development of chronic kidney disease (CKD) was investigated using a nationwide, population-based, retrospective cohort in South Korea. POAG increases the risk of subsequent CKD development. PURPOSE:The purpose of this study was to invest...

journal_title：Journal of glaucoma

authors： Park SJ,Byun SJ,Park JY,Kim M

更新日期：2019-12-01 00:00:00

abstract：:The multifunctional protein clusterin (CLU) is a secreted glycoprotein ubiquitously expressed throughout the body, including in the eye. Its primary function is to act as an extracellular molecular chaperone, preventing the precipitation and aggregation of misfolded extracellular proteins. Clusterin is commonly identi...

journal_title：Journal of glaucoma

authors： Wiggs JL,Kang JH,Fan B,Levkovitch-Verbin H,Pasquale LR

更新日期：2018-07-01 00:00:00

abstract：PURPOSES:To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments. METHODS:A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, an...

journal_title：Journal of glaucoma

authors： Ueda K,Kanamori A,Akashi A,Tomioka M,Kawaka Y,Nakamura M

更新日期：2016-04-01 00:00:00

abstract：:To prevent corneal endothelial cell loss, ciliary sulcus tube insertion is preferred for the pseudophakic eye. However, we sometimes encounter technical difficulties when inserting the tube through the sulcus. Even in cases in which we are able to insert a 23-G needle through the sulcus into the space between the iris...

journal_title：Journal of glaucoma

authors： Kasuga T,Asaoka S,Asada Y,Iwamoto S,Hirakata T,Honda R,Ohta T,Matsuda A

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) in primary and pseudoexfoliative open-angle glaucoma. MATERIALS AND METHODS:Patients for primary filtration surgery underwent CLASS with a CO2 laser system (OT-134-IOPtiMate, IOPtima Ltd., Ramat Gan, Israel). This self-controlled system...

journal_title：Journal of glaucoma

authors： Geffen N,Ton Y,Degani J,Assia EI

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:We performed a literature synthesis to identify the full spectrum of compounds implicated in drug-induced, bilateral secondary angle-closure glaucoma (2° ACG). METHODS:Systematic PubMed literature review identified relevant bilateral 2° ACG case reports. We evaluated these reports with both the Naranjo adverse...

journal_title：Journal of glaucoma

authors： Murphy RM,Bakir B,O'Brien C,Wiggs JL,Pasquale LR

更新日期：2016-02-01 00:00:00

abstract：AIMS:To compare the retinal nerve fiber layer thickness (RNFLT) parameters obtained with newly introduced GDx with enhanced corneal compensation (ECC) and those with GDx with variable corneal compensation (VCC) and to evaluate their reproducibility and the correspondence with visual field damage (VFD) in total or secto...

journal_title：Journal of glaucoma

authors： Saito H,Tomidokoro A,Yanagisawa M,Aihara M,Tomita G,Araie M

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:The authors identify any diurnal intraocular pressure (IOP) variation in healthy Cayo Santiago macaques, as well as Cayo Santiago macaques with normotensive and hypertensive primary open-angle glaucoma (POAG), to further evaluate their potential value as a model for human POAG. METHODS:Twenty-four monkeys (eig...

journal_title：Journal of glaucoma

authors： Komaromy AM,Brooks DE,Kubilis PS,Dawson WW,Sapp HL Jr,Nelson G,Collins BR,Sherwood MB

更新日期：1998-04-01 00:00:00