Delayed corneal epitheliopathy after antimetabolite-augmented trabeculectomy.

Abstract:

PURPOSE:The authors describe the first case of delayed antimetabolite-related corneal epithelial toxicity after trabeculectomy and its successful treatment with limbal stem cell transplantation. METHODS:A 73-year-old woman underwent trabeculectomy with intraoperative mitomycin C. After surgery she received six 5-mg injections of subconjunctival 5-fluorouracil (5-FU) adjacent to the bleb. RESULTS:The patient had a functioning trabeculectomy and clear cornea until 30 months after surgery, at which time she developed a nonhealing superior corneal epithelial defect. After 4 months of conservative medical management, an autologous limbal stem cell transplantation was performed. The epithelial defect resolved completely within 1 week of limbal stem cell transplantation. CONCLUSIONS:Delayed corneal epithelial toxicity may be a late complication of antimetabolite-augmented trabeculectomy.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Manche EE,Afshari MA,Singh K

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

237-9

issue

4

eissn

1057-0829

issn

1536-481X

journal_volume

7

pub_type

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