Abstract:
PURPOSE:To determine if a new, normative, race-specific database enhances the ability of confocal scanning laser ophthalmoscopy to differentiate normal from glaucomatous eyes. METHODS:One eye of eligible normal and glaucoma patients was enrolled. All subjects underwent a complete ophthalmologic examination, standard achromatic perimetry (SITA-SAP, 24-2), and confocal scanning laser ophthalmoscopy [Heidelberg retinal tomograph (HRT-II)] within 1 month of enrollment. Racial groups were defined by self-report. Glaucoma was defined by the existence of reproducible SAP loss (pattern standard deviation <5% and/or Glaucoma Hemifield Test outside normal limits) on 2 consecutive fields. Normal subjects had 2 normal visual fields (pattern standard deviation >5% and Glaucoma Hemifield Test within 97% normal limits) and a normal clinical examination. HRT-II examinations were exported to the HRT-III software, which includes a large race-specific normative database consisting of 733 white and 215 black eyes. Moorfields regression analysis (MRA) for the most abnormal optic disc sector was compared between the HRT-II (MRA2) and the HRT-III software before (MRA3-B) and after (MRA3-A) adjustment for race. Sectors outside the 99.9% confidence interval limits ("outside normal limits") were determined to be abnormal. RESULTS:We enrolled 124 black (52 glaucoma, 72 normal) and 96 white (32 glaucoma, 64 normal) subjects. Mean age was 51+/-13 years and 50+/-16 years for blacks and whites, respectively (P = 0.45). Visual field mean deviation was -7.3+/-6.7 db for glaucomatous eyes and -0.4+/-1.1 db for normal eyes (P < 0.001). Sensitivity and specificity for the HRT-II was 71.9% and 95.3%, respectively, for white subjects and 50.0% and 98.6%, respectively, for black subjects. Using the expanded HRT-III database, analysis yielded a sensitivity of 81.3% and specificity of 93.8% for whites and a sensitivity of 71.2% and specificity of 86.1% for blacks. After an adjustment for black ethnicity was made in the HRT-III program, the sensitivity and specificity for blacks was 65.4% and 90.3%, respectively. CONCLUSIONS:A new, larger, race-specific HRT-III database increases sensitivity while maintaining specificity for whites and increases sensitivity but decreases specificity for blacks. New software and databases based on race require careful scrutiny before use in clinical practice.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Zelefsky JR,Harizman N,Mora R,Ilitchev E,Tello C,Ritch R,Liebmann JMdoi
10.1097/01.ijg.0000212289.00917.a8subject
Has Abstractpub_date
2006-12-01 00:00:00pages
548-51issue
6eissn
1057-0829issn
1536-481Xpii
00061198-200612000-00013journal_volume
15pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to report a case of recurrent conjunctival erosion and XEN Gel Stent exposure after implantation in a primary open-angle glaucoma patient. Minimally invasive glaucoma surgery (MIGS) is a new approach in glaucoma surgery, and there is a lack of published data with regard to the mana...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001146
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182182567
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Glaucoma specialists and optometrists who work in a team model at a single institution utilize a common definition of glaucoma progression and treatment algorithm. The purpose of this study was to assess the consistency of agreement in identifying glaucoma progression among glaucoma specialists and optometrists...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000994
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To estimate the outpatient clinic burden and surgical workload related to glaucoma in Lagos, Nigeria. METHODS:A multicentre study involving the 2 tertiary eye institutions, 7 secondary eye centers with eye care facilities, and the largest private eye hospital in Lagos state, Nigeria. Data on outpatient departm...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0b013e318264cd80
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To study resident compliance with the American Academy of Ophthalmology (AAO) Preferred Practice Patterns (PPPs) for primary open-angle glaucoma suspect (POAGS) in a resident ophthalmology clinic. PATIENTS AND METHODS:Two hundred charts were selected for analysis of adult patients with the International Classi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000548
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To measure the change in intraocular pressure (IOP) of the fellow eye after glaucoma surgery in 1 eye. PATIENTS AND METHODS:In this prospective interventional study, 71 patients with primary and secondary glaucoma, undergoing glaucoma surgery in 1 eye were included. The IOP in the fellow eye following glaucoma...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000217
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To validate the Italian version of the Glaucoma Symptom Scale (GSS) Questionnaire and its symptoms and function subscales. METHODS:This transversal validation study enrolled nonhospitalized patients with glaucoma, and a reference sample of patients without eye diseases. Eligible participants had to be cognitiv...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318225406c
更新日期:2013-01-01 00:00:00
abstract::We determined the results of routine whole-field scotopic vision testing in consecutive patients with ocular hypertension or glaucoma who underwent Humphrey automated perimetric testing and optic disc examination. In 39 ocular hypertensive patients we found a mean threshold of 16.7 +/- 7.4 dB and in 61 glaucoma patien...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To determine the optimal OCT-3 scanning protocol. METHODS:Normal subjects, ocular hypertensive, and open-angle glaucoma patients were enrolled. The "fast" RNFL scan protocol consists of 3 consecutive circular scans, each containing 256 A-scans obtained in a single 1.92 second session. The "regular" RNFL scan p...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200404000-00010
更新日期:2004-04-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182120a08
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To evaluate an alternate method of covering the subconjunctival portion of the tube in aqueous shunt surgery. Evidence of tube erosion, graft-related infection, graft melting, or other associated intraocular complications were evaluated. METHODS:A retrospective study of 16 patients (17 eyes) who underwent tube...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:The purpose of the study was to compare radial peripapillary capillary (RPC) density between normal subjects and patients with early primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCT-A). MATERIALS AND METHODS:A total of 24 patients with early POAG and age-matched 52 normal ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000649
更新日期:2017-05-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000146363.90506.b2
更新日期:2005-02-01 00:00:00
abstract:PRECIS:Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU). PURPOSE:To evaluate 2 different concentr...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001215
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To determine the effect of cataract extraction on the glaucoma progression index (GPI) in glaucoma patients with coexisting cataract. PATIENTS AND METHODS:This is a retrospective noncomparative study. Consecutive eligible patients with glaucoma who underwent phacoemulsification alone or in combination with aug...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181b21fb9
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To investigate the amount of intraocular pressure (IOP) asymmetry in a large group of ethnically diverse patients with and without glaucoma, and to delineate the risk for glaucoma which increasing amounts of IOP asymmetry confer upon the patient. PATIENTS AND METHODS:Collaborative retrospective study of 326 gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318237bfb8
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare intraocular pressure measurements obtained with XPERT, an upgraded model of the noncontact tonometer, with those from Goldmann applanation tonometry. METHODS:An average of three intraocular pressure measurements, generated by the XPERT, was compared with a single readin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:To determine the outcomes of inferonasal Baerveldt glaucoma implant (BGI) surgery. PATIENTS AND METHODS:A retrospective, non-comparative case series of 182 eyes of 182 patients who underwent inferonasal placement of a Baerveldt glaucoma implant. The main outcome measures included intraocular pressure, number o...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ijg.0000195597.30600.27
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:Multiuse of the G-probe transscleral cyclophotocoagulation (TSCPC) device can lead to contamination. We evaluated the mechanical stability and clinical efficacy of a disposable sterile barrier for the G-probe footplate. METHODS:We measured diode laser output with and without the G-probe barrier both before and...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e08109
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To compare the difference between 2 methods of measuring the intraocular pressure (IOP), namely, Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT) and to study the relationship with the corneal parameters in patients with no glaucoma signs. METHODS:One hundred and eighteen eyes of 118 he...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31816224bd
更新日期:2008-09-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of a tube fenestration stented with a 10-0 polyglactin suture for controlling early postoperative intraocular pressure (IOP) after Baerveldt glaucoma implant (BGI) surgery. METHODS:The medical records of 110 patients (119 eyes) who underwent BGI surgery with a tube fenestrat...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000885
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To evaluate the results of Ahmed Glaucoma Valve surgery in neovascular glaucoma and control patients. PATIENTS AND METHODS:In this retrospective comparative study, we reviewed 76 eyes of 76 patients, comparing the surgical outcomes in control patients (N=38) to matched neovascular glaucoma patients (N=38). Suc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181ca7f7f
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To evaluate the neuroprotective effect of rasagiline (N-propargyl-1 (R)-aminoindan), a selective monoamine oxidase inhibitor, on the survival of retinal ganglion cells (RGCs) in glaucomatous rat eyes. Rasagiline is an FDA approved anti-Parkinson disease drug with neuroprotective capabilities that were shown in ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e3d101
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the changes in longitudinal retinal nerve fiber layer thickness (RNFLT) as determined by spectral-domain optical coherence tomography (OCT) after optic disc hemorrhage (DH) in glaucomatous eyes. METHODS:A total of 65 eyes with unilateral DH and 65 contralateral eyes wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000083
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:To measure the serum bile acids (SBA) in patients with primary open-angle glaucoma (POAG) and to compare with nonglaucomatous controls. PATIENTS AND METHODS:A hospital-based case control study of 90 patients above the age of 40 years was conducted. Patients with POAG formed the study group and individuals with...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000993
更新日期:2018-08-01 00:00:00
abstract:PURPOSE:To classify the appearance of the optic disc seen on fundus photographs of healthy subjects and patients with or suspected glaucoma whose diagnosis was based upon visual fields (VFs) and spectral-domain optical coherence tomography (sdOCT) results. PATIENTS AND METHODS:One eye of 100 patients with or suspected...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000640
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare early postoperative outcomes of patients who underwent Baerveldt 350-mm aqueous drainage device (Abbott Medical Optics Inc., Santa Ana, CA) implantation with and without 7-0 polyglactin (vicryl) suture placement through tube fenestration to serve as a stenting wick. MET...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001080
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:To report 2 cases of delayed-onset, bleb-related endophthalmitis induced by Gemella species. METHODS:Interventional case report. RESULTS:Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C. Both patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31818c6f07
更新日期:2009-08-01 00:00:00