Abstract:
PURPOSE:To evaluate the neuroprotective effect of rasagiline (N-propargyl-1 (R)-aminoindan), a selective monoamine oxidase inhibitor, on the survival of retinal ganglion cells (RGCs) in glaucomatous rat eyes. Rasagiline is an FDA approved anti-Parkinson disease drug with neuroprotective capabilities that were shown in many models of brain damage. MATERIALS AND METHODS:The neuroprotective effect of daily intraperitoneal (IP) injections of rasagiline (0.5 mg/kg and 3 mg/kg) was evaluated and compared with saline injections using the translimbal photocoagulation model of experimental glaucoma in Wistar rats. Intraocular pressure (IOP) was measured before and immediately after the laser treatment, and then weekly. Seven weeks after the induction of glaucoma, the animals were killed, the eyes were enucleated and the retinas were prepared as whole mounts. Fluoro-gold had been injected into the superior colliculus 10 days before enucleation, and RGC survival was evaluated by counting the surviving labeled RGCs in a masked way. RESULTS:All rats (n=29) displayed significant IOP elevation and RGC damage. Seven weeks after the induction of glaucoma, the mean RGC survival was 43±8% in the rasagiline 3 mg/kg-treated group and 43±9% in the rasagiline 0.5 mg/kg-treated group compared with 23%±4% in the saline-treated (control) group (P=0.01 and P=0.02, respectively). CONCLUSION:Systemic treatment with rasagiline significantly enhances the survival of RGCs in experimental glaucoma.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Levkovitch-Verbin H,Vander S,Melamed Sdoi
10.1097/IJG.0b013e3181e3d101subject
Has Abstractpub_date
2011-06-01 00:00:00pages
273-7issue
5eissn
1057-0829issn
1536-481Xjournal_volume
20pub_type
杂志文章abstract::PRéCIS:: The potential parameters for differentiating pupillary block (PB) from plateau iris configuration (PIC) on anterior segment optical coherence tomography (ASOCT) are lens/pupil size parameters and angles. Further study is needed to determine a landmark peripheral to the centroid of the iris. PURPOSE:Investiga...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001664
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To report 2-year results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics, Álava, Spain), a nonabsorbable hema implant, and the morphologic analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS:In tota...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000756
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of modified deep sclerectomy [D-lectomy mitomycin C (MMC)] for medically refractory glaucoma patients. METHODS:In a retrospective comparative study, the surgical outcome in 1 eye each of 31 patients who underwent D-lectomy MMC was compared with that of 91 eyes of 91 patients who underwe...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181752cc8
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:To determine the prevalence of abnormal short-wavelength automated perimetry (SWAP) visual fields in subjects with elevated intraocular pressures (IOP) for 7 existing definitions of mild glaucomatous loss, and to explore the agreement between them. PATIENTS AND METHODS:Seven hundred and forty-four eyes of 379 ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000146363.90506.b2
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:Impairment of the blood-aqueous barrier in unoperated eyes with pseudoexfoliation syndrome has been demonstrated by fluorescein angiography, fluorophotometry, measurement of aqueous flare, and determination of aqueous protein. We performed noninvasive quantification of aqueous flare using the laser flare-cell m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::Glaucoma secondary to penetrating keratoplasty can be challenging and multiple surgeries may be needed to control the intraocular pressure (IOP), including the use of glaucoma drainage implants. However, late failure of these drainage implant surgery is common, mostly because of excessive scarring or bleb encapsulatio...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000739
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To evaluate the incidence of glaucoma and elevation of intraocular pressure (IOP) in patients with inflammatory eye disease. METHODS:Retrospective review of medical records of 391 consecutive patients with uveitis attending a uveitis clinic of an academic Department of Ophthalmology from January 1999 to August...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000146391.77618.d0
更新日期:2004-12-01 00:00:00
abstract:PURPOSE:The pattern of the distribution of nerve fiber layer (NFL) thickness values across the retina may provide an early anatomic indication of glaucomatous disruption. We developed a method of analyzing polarimetry measurements that emphasizes the shape of the pattern of NFL thickness values. Sensitivity and specifi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200012000-00005
更新日期:2000-12-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200112000-00009
更新日期:2001-12-01 00:00:00
abstract:INTRODUCTION:Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described. METHODS:We present a case of...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001016
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of the spectral-domain optical coherence tomography (SD OCT)-determined ganglion cell complex thickness to total retinal thickness ratio (G/T ratio) in diagnosing glaucoma. METHODS:A total of 99 eyes with primary open-angle glaucoma and 35 normal eyes were enrolled in the study. SD O...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31825af58a
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To identify and characterize 'reversal' of optic nerve cupping following intraocular pressure (IOP) lowering in scanning laser tomography (SLT) longitudinal image series. METHODS:Modification was made to a previously described analytical approach to longitudinally study putatively increased rim area following ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000133151.82804.e3
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To study the frequencies and factors associated with 4 disc patterns in primary open-angle glaucoma (POAG) identified in population-based studies: focal glaucomatous (FG type), generalized enlargement of cup (GE type), myopic glaucomatous (MG type), and senile sclerotic glaucomatous (SS type) patterns. SUBJECT...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001240
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To examine the relationship between retinal ganglion cell function measured using pattern electroretinogram optimized for glaucoma screening (PERGLA), retinal nerve fiber layer (RNFL) thickness, and optic nerve head topography. METHODS:Twenty-nine normal, 28 glaucoma, and 37 glaucoma suspect volunteers were en...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31819afb5c
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To determine the relationship between mean deviation (MD) scores and resource utilization among glaucoma patients in the United States and Europe. METHODS:A retrospective analysis of patient in the United States (June 1990 to January 2003, N=151) and Europe (June 1994 to July 2003, N=194) was conducted. Office...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181879ea0
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To correlate Humphrey visual field mean sensitivity and peripapillary nerve fiber layer thickness as measured by scanning laser polarimetry. METHODS:The authors studied 54 eyes of 34 patients who visited a university-based glaucoma clinic and had undergone scanning laser polarimetry and Humphrey perimetry with...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200008000-00001
更新日期:2000-08-01 00:00:00
abstract:PRECIS:In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE:The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XF...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001496
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG). PATIENTS AND METHODS:Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured i...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181a98f30
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To investigate the efficacy of currently available correction factors in correcting intraocular pressure (IOP) measurements for the errors induced by the normal variations in corneal structural characteristics. MATERIALS AND METHODS:Central corneal thickness (CCT) and corneal radius of curvature were measured ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000176940.81799.33
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To evaluate rates of adherence to free follow-up eye exam appointments among participants in the Philadelphia Glaucoma Detection and Treatment Project. PATIENTS AND METHODS:Ophthalmologists and testing equipment were brought directly to participants at risk for glaucoma at 43 community sites in Philadelphia. T...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000716
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To investigate the practice patterns among glaucoma subspecialists in the American Glaucoma Society regarding the management of blebitis. METHODS:An anonymous survey incorporating 14 questions regarding the management of blebitis was mailed to all current active American Glaucoma Society members, including pro...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200108000-00015
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:Pseudoexfoliation (PEX) syndrome, an age-related, systemic, elastic microfibrillopathy, is characterized by fibrillar-granular deposits in the anterior segment of the eye. Although not representing a true amyloidosis, PEX syndrome shares some features with amyloid disorders, such as Alzheimer disease. It has be...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181ca76c4
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS:This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randoml...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200204000-00008
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To compare the abilities of standard automated perimetry (SAP) and spectral-domain optical coherence tomography (SDOCT) in diagnosing eyes with glaucomatous optic neuropathy (GON). METHODS:In a cross-sectional study, 280 eyes of 175 subjects referred to tertiary eye care center by general ophthalmologists for ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000048
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:This meta-analysis aims to comprehensively evaluate the association between total homocysteine (tHcy) levels, serum folic acid, vitamin B12, vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, and risk of normal-tension glaucoma (NTG). MATERIALS AND METHODS:A systematic search of ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/IJG.0000000000000269
更新日期:2016-02-01 00:00:00
abstract::Treatment with noncardioselective beta-adrenoceptor antagonists (e.g., 0.5% timolol or 0.5% levobunolol) is standard practice for lowering elevated intraocular pressure (IOP). However, because there are risks and side effects associated with the use of these agents, a lower, yet still effective, dose may be preferred....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-199201040-00005
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To compare the efficacy and tolerability of latanoprost or brimonidine in patients with elevated intraocular pressure (IOP). MATERIALS AND METHODS:This prospective, randomized, masked-evaluator, parallel-group, multicenter study in the United States included patients with primary open angle glaucoma or ocular ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.ijg.0000151881.99607.4e
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To measure the interobserver agreement of Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany) parameters as a result of different observers' contour line placement. METHODS:The optic nerve heads of 50 patients with glaucoma were imaged with the HRT. Five observers traced each disc ma...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to improve the scanning peripheral anterior chamber depth analyzer (SPAC) for measuring anterior chamber depth (ACD), differentiating eyes with shallow anterior chamber, and automatically categorizing eyes into subgroups based on the ACD values. We also investigated its accuracy for me...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212256.25573.44
更新日期:2006-10-01 00:00:00