Abstract:
PURPOSE:The pattern of the distribution of nerve fiber layer (NFL) thickness values across the retina may provide an early anatomic indication of glaucomatous disruption. We developed a method of analyzing polarimetry measurements that emphasizes the shape of the pattern of NFL thickness values. Sensitivity and specificity for detecting glaucoma was obtained for these measures and compared with those for conventional measures. METHODS:Nerve fiber thickness was inferred from retardation shift measured by a scanning laser polarimeter (Laser Diagnostic Technologies, Inc., San Diego, CA) in 34 healthy subjects (68 eyes) and 34 patients with glaucoma (68 eyes). Fourier analysis was performed on the polarimetry data to emphasize the shape in the evaluation of the distribution of thickness values around the optic disc (along a 1.7-disc diameter ring). This was computed separately on superior and inferior hemiretinas. RESULTS:Significant differences were found in the Fourier shape measures between healthy subjects and patients with glaucoma. The sensitivity and specificity using Fourier coefficients with this particular sample was 96% and 90%, respectively. CONCLUSION:The evaluation of NFL measurements with Fourier analysis to emphasize the holistic shape of the "double-hump" pattern was found to be a useful tool as an analysis strategy.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Essock EA,Sinai MJ,Fechtner RD,Srinivasan N,Bryant FDdoi
10.1097/00061198-200012000-00005keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
444-52issue
6eissn
1057-0829issn
1536-481Xjournal_volume
9pub_type
杂志文章abstract:PURPOSE OF THE STUDY:The purpose of the study was to evaluate the long-term effectiveness and safety profile of Baerveldt glaucoma implant (BGI) in patients with refractory glaucoma operated using a modified technique to avoid postoperative complications. PATIENTS AND METHODS:A total of 160 eyes from 147 glaucomatous ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000488
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To compare the replacement of every drug with latanoprost 0.005% once a day in glaucomatous eyes with poorly controlled intraocular pressure upon combination therapy, versus addition of latanoprost to the pre-existing treatment. PATIENTS AND METHODS: STUDY DESIGN:prospective, investigator-masked, two-center, ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00061198-200308000-00009
更新日期:2003-08-01 00:00:00
abstract::We report a case of an explanted stainless steel miniature glaucoma drainage device (EX-PRESS) implanted under a scleral flap for pseudoexfoliation open-angle glaucoma surgical treatment. The glaucoma shunt was implanted in a 75-year-old white man with medically refractive glaucoma. Cataract surgery was performed simu...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000521
更新日期:2017-01-01 00:00:00
abstract::PRéCIS:: In primary open-angle glaucoma (POAG), unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density (VD) than with ganglion cell complex (GCC) thickness of the opposite macular hemifield. PURPOSE:The aim of this study was to compare the re...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001441
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of the spectral-domain optical coherence tomography (SD OCT)-determined ganglion cell complex thickness to total retinal thickness ratio (G/T ratio) in diagnosing glaucoma. METHODS:A total of 99 eyes with primary open-angle glaucoma and 35 normal eyes were enrolled in the study. SD O...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31825af58a
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:To examine the effect of the myopic optical defocus on the Humphrey Matrix 30-2 test. DESIGN:Prospective, nonrandomized, comparative case series. METHODS:Forty eyes from 40 patients with and without glaucoma underwent 2 consecutive tests using the Humphrey Matrix 30-2 threshold program. The first and second t...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181b21ef6
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:The authors describe the first case of delayed antimetabolite-related corneal epithelial toxicity after trabeculectomy and its successful treatment with limbal stem cell transplantation. METHODS:A 73-year-old woman underwent trabeculectomy with intraoperative mitomycin C. After surgery she received six 5-mg in...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:PURPOSE:To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS:This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randoml...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200204000-00008
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:To evaluate the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex, and macular thickness as well as their correlation with the severity of diseases. MATERIALS AND METHODS:This is a cross-sectional study and comparing both eyes of 26 patients with primary open-angle glaucoma, 25 patients wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000239
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To evaluate aqueous levels of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with branch retinal vein occlusion (BRVO) with and without normal tension glaucoma (NTG), and to assess the therapeutic efficacy of intravitreal bevacizumab (IVB) in these patients. METHODS:Sixteen eyes ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182312047
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:To report a woman with congenital rubella syndrome of delayed-onset, bleb-related endophthalmitis induced by Streptococcus intermedius. METHODS:Interventional case report. RESULTS:A 33-year-old woman who underwent bilateral trabeculectomy with adjunctive mitomycin C, 11 years earlier presented with redness an...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318170a732
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To evaluate and compare outcomes of eyes that underwent laser suture lysis (LSL) after initial trabeculectomy with mitomycin C (MMC) to those that did not require such an intervention. METHODS:We reviewed the charts of consecutive patients with open-angle glaucoma who underwent initial trabeculectomy with mito...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000195929.94922.a2
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To evaluate the diagnostic ability of macular parameters and peripapillary retinal nerve fiber layer (RNFL) parameters for early glaucoma using spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS:One eye from 32 early glaucoma patients (including preperimetric glaucoma) and 32 normal p...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e079ed
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To determine the relation between office intraocular pressure (IOP) and 24-hour IOP in patients with primary open-angle glaucoma (POAG) treated with 3 kinds of antiglaucoma eye drops. PATIENTS AND METHODS:Subjects were 42 patients with POAG (71 eyes). All were being treated with 3 different topical antiglaucom...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31802ff85f
更新日期:2007-03-01 00:00:00
abstract::Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-S...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001641
更新日期:2020-10-01 00:00:00
abstract::A 78-year-old man with angle closure glaucoma and on treatment with oral anticoagulants, underwent phacoemulsification. An early acute suprachoroidal hemorrhage (SCH) occurred and the surgical wound was rapidly sutured without complete soft lens matter removal, nor insertion of intraocular lens. The SCH was managed co...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001170
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Our purpose was to investigate the effects of the calcium channel blocker verapamil on intraocular pressure and blood circulation in the human optic nerve head. METHODS:The effects of three different concentrations of topical verapamil (0.063%, 0.125%, and 0.25%) on intraocular pressure and optic nerve head ca...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:To report the prevalence, long-term changes and associated factors for pseudoexfoliation (PEX) in a population aged 40 years and above from rural and urban south India. MATERIALS AND METHODS:At baseline (the Chennai Glaucoma Study), 7774 subjects were examined. After 6 years, as a part of the incidence study, ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000276
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the outcomes of trabeculectomy with mitomycin-C (MMC) in uveitis associated with Vogt-Koyanagi-Harada disease (VKH). METHODS:Retrospective cohort study included 27 eyes of 15 patients with uveitic glaucoma associated with VKH disease who underwent trabeculectomy with MMC as a first glaucoma proc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000384
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Impairment of the blood-aqueous barrier in unoperated eyes with pseudoexfoliation syndrome has been demonstrated by fluorescein angiography, fluorophotometry, measurement of aqueous flare, and determination of aqueous protein. We performed noninvasive quantification of aqueous flare using the laser flare-cell m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract:PURPOSE:Measurement of intraocular pressure is affected by the shape and thickness of the cornea, and corneal shape is thought to be maintained by contraction of corneal fibroblasts. The effects of the antiglaucoma drugs latanoprost, timolol maleate, and pilocarpine on the contraction of corneal fibroblasts cultured in...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212210.33265.24
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of CO2 Laser-assisted Sclerectomy Surgery (CLASS) in primary and pseudoexfoliative open-angle glaucoma. MATERIALS AND METHODS:Single-arm, open-label study included data from 9 medical centers located in 7 countries. Subjects underwent nonpenetrating CLASS procedure with a CO...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000000437
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To investigate risk factors associated with glaucomatous progression in pseudoexfoliation glaucoma (PXG) patients. PATIENTS AND METHODS:A retrospective observational study with a total of 48 PXG patients and age, sex, and visual field (VF) test mean deviation-matched 48 primary open-angle glaucoma (POAG) patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000791
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To assess the comparative efficacy and safety of primary deep sclerectomy (DS) augmented with subconjunctival Bevacizumab and intraoperative Mitomycin C (MMC). METHODS:Retrospective, comparative case-control series of consecutive primary DS between January 2008 and December 2010. Seventy-five eyes of 73 patien...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182883c0c
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To describe the outcome of surgical bleb revision for late-onset bleb leaks after trabeculectomy. PATIENTS AND METHODS:Appropriate cases were identified. Qualified and complete success required intraocular pressure of 21 mm Hg or less with and without glaucoma medication use, respectively. Bleb survival was de...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31821e83e6
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To assess and compare the impact of medical and surgical glaucoma treatments on patients' health-related Quality of Life (QoL). MATERIALS AND METHODS:We used the 25-question version of the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) for this cross-sectional study. Patients were divided...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824ceb8b
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Investigate efficacy and safety of bleb revision using mitomycin C after Ex-PRESS shunt surgery. PATIENTS AND METHODS:We performed chart reviews of 36 consecutive eyes from 34 patients with previous Ex-PRESS shunt surgery who underwent subsequent bleb revision with mitomycin C. The mean follow-up time was 13.5...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000308
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::We report 2 bilateral cases that presented as primary ocular hypertension and primary angle-closure glaucoma, respectively; however, they were subsequently discovered to be harboring secretory pituitary tumors. After transsphenoidal tumor resection, intraocular pressures (IOPs) in all 4 eyes returned to normal levels....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31829521f2
更新日期:2015-03-01 00:00:00