Comparison of Thickness-Function and Vessel Density-Function Relationship in the Superior and Inferior Macula, and in the Superotemporal and Inferotemporal Peripapillary Sectors.

Abstract:

:PRéCIS:: In primary open-angle glaucoma (POAG), unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density (VD) than with ganglion cell complex (GCC) thickness of the opposite macular hemifield. PURPOSE:The aim of this study was to compare the relationship of the spatially corresponding superficial retinal capillary VD and retinal thickness parameters with the corresponding visual field sensitivity, for the superior and inferior macula, and the superotemporal and inferotemporal peripapillary sectors, respectively. PATIENTS AND METHODS:One eye of 27 POAG, 14 ocular hypertensive, and 9 healthy participants were subjected to optical coherence tomography angiography imaging with the Angiovue optical coherence tomography and Octopus G2 perimetry on the same day. Superior and inferior unlogged hemifield average macular sensitivity was correlated with the opposite macular hemifield VD and GCC thickness, respectively. Correlation of visual field cluster unlogged average sensitivity with the spatially corresponding sector VD and sector retinal nerve fiber layer thickness were compared for the superotemporal and inferotemporal peripapillary sector, respectively. RESULTS:For all participants and the glaucoma population, the correlations for macular hemifield GCC were strong or very strong (r: 0.554 to 0.737, P<0.01). In these groups, the correlations for macular hemifield VD were all very strong (r: 0.823 to 0.838, P<0.0001) and significantly higher than the corresponding correlations for hemifield GCC (P≤0.050). No significant difference between the corresponding correlations was found in the combined normal and ocular hypertensive group for the macular hemifields, or in either population for the peripapillary sectors. CONCLUSION:Our results suggest that, in contrast to superotemporal and inferotemporal peripapillary sectors in which the thickness-function and VD-function relationships are similar, in POAG, for the macular hemifields, the VD-function relationship is stronger than the thickness-function relationship.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Holló G

doi

10.1097/IJG.0000000000001441

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

168-174

issue

3

eissn

1057-0829

issn

1536-481X

journal_volume

29

pub_type

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