Abstract:
PURPOSE:Measurement of intraocular pressure is affected by the shape and thickness of the cornea, and corneal shape is thought to be maintained by contraction of corneal fibroblasts. The effects of the antiglaucoma drugs latanoprost, timolol maleate, and pilocarpine on the contraction of corneal fibroblasts cultured in a 3-dimensional collagen gel were investigated. The effects of these drugs on collagen degradation by corneal fibroblasts and their possible cytotoxicity were also examined. MATERIALS AND METHODS:Human corneal fibroblasts were cultured in a 3-dimensional gel of type I collagen and in the presence of various concentrations of latanoprost, timolol maleate, or pilocarpine for various times. Collagen gel contraction was evaluated by daily measurement of gel diameter. The extent of collagen degradation was determined by measurement of the amount of hydroxyproline generated by acid-heat hydrolysis of culture supernatants. The release of lactate dehydrogenase from corneal fibroblasts was determined as an index of drug cytotoxicity. RESULTS:Latanoprost stimulated collagen gel contraction mediated by corneal fibroblasts in a concentration- and time-dependent manner, whereas timolol maleate and pilocarpine had no such effect. None of the 3 drugs affected collagen degradation by corneal fibroblasts or exhibited cytotoxicity at concentrations as high as 100 muM. CONCLUSIONS:Among the antiglaucoma drugs examined, only latanoprost stimulated collagen gel contraction mediated by human corneal fibroblasts. This action of latanoprost might affect corneal shape and thereby influence measurement of intraocular pressure.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Liu Y,Yanai R,Lu Y,Hirano S,Sagara T,Nishida Tdoi
10.1097/01.ijg.0000212210.33265.24subject
Has Abstractpub_date
2006-06-01 00:00:00pages
255-9issue
3eissn
1057-0829issn
1536-481Xpii
00061198-200606000-00013journal_volume
15pub_type
杂志文章abstract:PURPOSE:To determine the correlation of central corneal thickness (CCT) to Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT, PASCAL), and to glaucoma stage as assessed by cup-to-disc ratio (CDR). DESIGN:Prospective, cross-sectional tricenter observation study. PATIENTS AND METHODS:From three gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/00061198-200604000-00003
更新日期:2006-04-01 00:00:00
abstract:PURPOSE OF THE STUDY:The purpose of the study was to evaluate the clinical efficacy of swept-source optical coherence tomography (SS-OCT), we compared the intradevice repeatability of thickness measurements obtained using SS-OCT to that of measurements obtained using spectral domain OCT (SD-OCT), and assessed the inter...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000536
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To compare the accuracy of the "ISNT" rule [neural rim width of inferior(I)≥superior(S)≥nasal(N)≥temporal(T) regions] and the abbreviated variant, the "IS" rule (inferior≥superior regions) to differentiate normal from glaucomatous eyes. MATERIALS AND METHODS:Medical records of patients who were evaluated in 20...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000072
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of day-long sequential office measurements of intraocular pressure (IOP) to make therapeutic decisions in patients with progressive glaucomatous damage despite apparently 'controlled' IOP. METHODS:We reviewed the records of 93 consecutive glaucoma patients (185 eyes) who underwent se...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000159125.34241.79
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:To describe a surgical technique to improve visualization and surgical access for trabeculectomy and implantation of aqueous drainage devices. MATERIALS AND METHODS:After the corneal traction suture (6-0 polygalactin; S-29 needle) is placed, a second suture is passed through Tenon's capsule alone, either at th...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200212000-00014
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To evaluate the effect of a single treatment of contact diode laser transscleral cyclophotocoagulation (TSCP) on intraocular pressure (IOP) in patients with refractory glaucoma and perform a historical meta-analysis of the relationship between successful IOP control and various laser parameters. METHODS:Clinic...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/00061198-200208000-00009
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:To evaluate tonometric outcomes of patients with primary angle closure glaucoma (PACG) who have undergone trabeculectomy with mitomycin C (MMC) with and without concurrent phacoemulsification and to identify risk factors for postoperative failure. PATIENTS AND METHODS:Retrospective cohort study of 44 eyes of 3...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000493
更新日期:2016-09-01 00:00:00
abstract::We determined the results of routine whole-field scotopic vision testing in consecutive patients with ocular hypertension or glaucoma who underwent Humphrey automated perimetric testing and optic disc examination. In 39 ocular hypertensive patients we found a mean threshold of 16.7 +/- 7.4 dB and in 61 glaucoma patien...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Clinical practice guidelines (CPG) are regarded by many as critical communications providing guidance within specific medical fields. Over a decade ago, the first microinvasive glaucoma surgical (MIGS) procedures were introduced. Since then, a number of these novel intraocular pressure controlling surgical...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000820
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To describe a new and simple technique of glaucoma tube extension that carries several advantages over previously described techniques. PATIENTS AND METHODS:A retrospective noncomparative case series of 3 patients (1 adult and 2 pediatric cases) with glaucoma tube retraction managed by the "tube-in-tube" techn...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000567
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To report a simple technique for removal of malpositioned Ex-PRESS miniature glaucoma filtration device. PATIENT AND METHODS:A patient who underwent removal of a malpositioned Ex-PRESS shunt from the right eye with wound revision. RESULTS:Description of step-by-step technique for removal of the Ex-PRESS shunt...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827b1540
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of the krypton laser for transscleral contact cyclophotocoagulation in the treatment of posttraumatic glaucoma. PATIENTS AND METHODS:A total of 18 eyes of 18 patients with therapy-resistant posttraumatic glaucoma treated with krypton laser cyclophotocoagulation from 1991 to 1996 were...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200104000-00002
更新日期:2001-04-01 00:00:00
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journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001080
更新日期:2018-12-01 00:00:00
abstract::PRéCIS:: Glaucomatous eyes without detectable 10-2 visual field loss showed significant macular vessel density loss, especially in inferior quadrant of perifoveal area. Macular vessel density loss spatially corresponded with structural and functional damage. PURPOSE:The purpose of this study was to investigate the ch...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001578
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:The most common reason for long-term failure of glaucoma filtering surgery (GFS) is scarring of the external filtering "bleb" tissues. The identification of the factors that mediate this process, as well as the development and initial testing of new therapies to limit scarring is enhanced by the use of appropri...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000131482.86547.5a
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To determine if laser iridotomy altered the anterior segment anatomy of patients with plateau iris configuration. METHODS:Twenty eyes of 9 female and 1 male patients were imaged using an ultrasound biomicroscope within 19 weeks before and 52 weeks after laser iridotomy. Measurements obtained included the anter...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000151687.96785.03
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To determine the effect of cataract extraction on the glaucoma progression index (GPI) in glaucoma patients with coexisting cataract. PATIENTS AND METHODS:This is a retrospective noncomparative study. Consecutive eligible patients with glaucoma who underwent phacoemulsification alone or in combination with aug...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181b21fb9
更新日期:2010-04-01 00:00:00
abstract:PURPOSES:To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments. METHODS:A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, an...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000216
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:The aims of this study were to observe the changes in the demand for prescriptions of ocular hypertensive drug (OHD) after cataract surgery, to investigate patterns of change in the required OHD amount in open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) cases, and to determine the associated factors r...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000969
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To estimate the outpatient clinic burden and surgical workload related to glaucoma in Lagos, Nigeria. METHODS:A multicentre study involving the 2 tertiary eye institutions, 7 secondary eye centers with eye care facilities, and the largest private eye hospital in Lagos state, Nigeria. Data on outpatient departm...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0b013e318264cd80
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To obtain retinal nerve fiber layer (RNFL) measurements by optical coherence tomography in a local, normal Hong Kong Chinese population and to identify the correlation of the measurement with age cross-sectionally. METHODS:A total of 129 normal Hong Kong Chinese volunteers of different age groups were recruite...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200212000-00004
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To investigate levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in the aqueous humor and plasma of patients with pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG), compared with controls. METHODS:This prospective study involved 37 patients with PXS, 15 with PXG, and...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181aae93e
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG). PATIENTS AND METHODS:Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured i...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181a98f30
更新日期:2010-03-01 00:00:00
abstract::Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-S...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001641
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To investigate the amount of intraocular pressure (IOP) asymmetry in a large group of ethnically diverse patients with and without glaucoma, and to delineate the risk for glaucoma which increasing amounts of IOP asymmetry confer upon the patient. PATIENTS AND METHODS:Collaborative retrospective study of 326 gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318237bfb8
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Management of a case of glaucoma secondary to an iris metastasis is reported. RESULTS:A 31-year-old woman developed glaucoma secondary to a metastatic tumor to the iris. Anti-glaucoma medication failed to control the increase in intraocular pressure (IOP). However, diode laser cyclophotocoagulation controlled ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract:PURPOSE:We explored the risk factors for glaucoma blindness among adults aged 40 years and above with primary glaucoma in Nigeria. PARTICIPANTS AND METHODS:A total of 13,591 participants aged 40 years and above were examined in the Nigeria Blindness Survey; 682 (5.02%; 95 CI, 4.60%-5.47%) had glaucoma by ISGEO's crite...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000487
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:To find the dropout rate and identify the clinical characteristics of patients who drop out in the first year of follow-up from a glaucoma clinic. DESIGN:Descriptive hospital-based study at a tertiary hospital eye department. METHODS:Clinical characteristics of consecutive patients newly diagnosed with glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31815768b3
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:To investigate the efficacy of argon laser trabeculoplasty (ALT) for the treatment of primary open-angle glaucoma (POAG) and of glaucoma associated with exfoliation syndrome (EXF). METHODS:Review of > 200 charts from patients treated with ALT between 1981 and 1987 identified 66 POAG and 29 EXF eyes that underw...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::A 54-year-old Indian male with a diagnosis of ocular hypertension was started on a prostaglandin analog (PGA) in both eyes to lower intraocular pressure. Six years later, he developed progressively increasing bilateral limbal conjunctival hyperpigmentation. Travoprost was discontinued and replaced with brinzolamide an...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000255
更新日期:2016-01-01 00:00:00