Abstract:
:PRéCIS:: Glaucomatous eyes without detectable 10-2 visual field loss showed significant macular vessel density loss, especially in inferior quadrant of perifoveal area. Macular vessel density loss spatially corresponded with structural and functional damage. PURPOSE:The purpose of this study was to investigate the characteristics, intereye and intraeye asymmetry of macular vessel density assessed by optical coherence tomography (OCT) angiography in bilateral early open-angle glaucoma with unilateral 10-2 visual field loss. MATERIALS AND METHODS:Thirty-two eyes of 16 patients with bilateral early open-angle glaucoma and unilateral 10-2 visual field loss, and 13 eyes of 13 healthy participants were consecutively enrolled. All subjects underwent 30-2, 10-2 visual fields, OCT, and OCT angiography examinations. Intereye differences were compared between the perimetrically affected eye and the unaffected eye in the same patient. Intraeye differences were compared between the affected hemifields and the unaffected hemifields in the same eye with single-hemifield 10-2 visual field loss. RESULTS:Macular whole image vessel density of the perimetrically unaffected eyes was lower than the healthy eyes (46.6% vs. 51.1%; P<0.001). Parafoveal vessel density parameters of the perimetrically affected eyes were comparable to the unaffected eyes (all P>0.05). Although inferior perifoveal vessel density of the perimetrically affected eyes was significantly lower than the unaffected eyes (42.2% vs. 46.2%; P=0.007), similar results were found in macular ganglion cell complex. In glaucomatous eyes with single-hemifield loss, perifoveal vessel density and macular ganglion cell complex of the affected hemifields were significantly worse than the unaffected hemifields (43.6% vs. 47.0%, 78.4 μm vs. 89.0 μm; P=0.023 and 0.005; respectively). CONCLUSIONS:Significant macular microvascular damage was present in glaucomatous eyes without detectable 10-2 visual field damage. The damage of inferior perifoveal vessel density was more significant in early glaucoma. Macular microvascular damage spatially corresponded with functional and structural damage.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Lu P,Xiao H,Chen H,Ye D,Huang Jdoi
10.1097/IJG.0000000000001578subject
Has Abstractpub_date
2020-10-01 00:00:00pages
926-931issue
10eissn
1057-0829issn
1536-481Xjournal_volume
29pub_type
杂志文章abstract:PURPOSE:The purpose of this study was to determine the proportion of patients in the US population who are receiving long-term intraocular pressure (IOP)-lowering medication, but, deny having a diagnosis of glaucoma or elevated IOP. MATERIALS AND METHODS:The National Health and Nutrition Examination Survey (NHANES) is...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001035
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:To assess the prevalence of optic disc hemorrhage in Asian patients with established glaucoma using a recently described, highly sensitive detection method. MATERIALS AND METHODS:Patients entering a trial of glaucoma filtering surgery in Southeast Asia (The Singapore 5FU Study) were assessed for the presence o...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200306000-00008
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:Upper eyelid sulcus deepening has recently been reported as an adverse effect of prostaglandin (PG) eye drop use. However, no data are available regarding the frequency of upper eyelid sulcus deepening caused by different types of PG eye drops. We used 5 types of PG eye drops in Japanese subjects and examined t...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824d8d7c
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:The purpose of this study was to report presentation and outcomes of coexisting congenital glaucoma with retinopathy of prematurity (ROP) in "Indian Twin cities ROP study (ITCROPS)." METHODS:Children with ROP and congenital glaucoma were identified from ITCROPS (prospective digital database) between 1997 and 2...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001124
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:The interpretation of changes in serial intraocular pressure (IOP) measurements are critical in the diagnosis and management of glaucoma. Differentiating true change from test-retest variability (TRV) in IOP measurements using Goldmann applanation tonometry (IOPG) is essential when reviewing these measurements....
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000001144
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To report the prevalence, long-term changes and associated factors for pseudoexfoliation (PEX) in a population aged 40 years and above from rural and urban south India. MATERIALS AND METHODS:At baseline (the Chennai Glaucoma Study), 7774 subjects were examined. After 6 years, as a part of the incidence study, ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000276
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To determine the frequency of epiretinal membranes (ERM) in eyes with primary open-angle glaucoma subjected to trabeculectomy. METHODS:We conducted a retrospective study on patients subjected to trabeculectomy with at least a 6-month follow-up. Ophthalmologic examination and spectral-domain optical coherence t...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000326
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of modified deep sclerectomy [D-lectomy mitomycin C (MMC)] for medically refractory glaucoma patients. METHODS:In a retrospective comparative study, the surgical outcome in 1 eye each of 31 patients who underwent D-lectomy MMC was compared with that of 91 eyes of 91 patients who underwe...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181752cc8
更新日期:2009-02-01 00:00:00
abstract:AIM:Dietary deficiencies in ω-3 polyunsaturated fatty acids are known to effect retinal function including retinal ganglion cell (RGC) activity, which may have implications for glaucoma. In this study we consider retinal function after dietary manipulation and intraocular pressure (IOP) stress designed to compromise RG...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318237cac7
更新日期:2013-04-01 00:00:00
abstract:PURPOSE:The pattern of the distribution of nerve fiber layer (NFL) thickness values across the retina may provide an early anatomic indication of glaucomatous disruption. We developed a method of analyzing polarimetry measurements that emphasizes the shape of the pattern of NFL thickness values. Sensitivity and specifi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200012000-00005
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:Traditionally, during trabeculectomy, Mitomycin-C (MMC) is applied to the tissues using surgical sponges. However, alternate modes of application exist. This study assessed the success rates, complication rates, final intraocular pressure (IOP), and bleb characteristics between patients receiving subtenon MMC a...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0000000000000830
更新日期:2018-02-01 00:00:00
abstract::Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell de...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827a0875
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:(1) To propose the use of episcleral venous outflow (EVO) as an outcome marker of iStent surgery, and an EVO grading scale. (2) To determine the association of EVO with: (a) postoperative intraocular pressure (IOP) and medication burden; (b) iStent patency status. PATIENTS AND METHODS:Retrospective cohort stud...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000799
更新日期:2017-12-01 00:00:00
abstract::Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-S...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001641
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To investigate the effects of dehydration and fasting on retrobulbar-vessel blood velocity in healthy subjects. METHODS:Twenty-eight eyes of 28 normal subjects without ocular disease were enrolled in this study. Each subject had a baseline color-Doppler imaging ultrasound of the central retinal artery, tempora...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200210000-00007
更新日期:2002-10-01 00:00:00
abstract:PURPOSE:To study the relationship between optic disc hemorrhages and four different groups of medications used in general vascular disease and diabetes. METHODS:The authors screened citizens of the city of Malmö, Sweden who were between 57 and 79 years old (32,918 subjects), in order to find individuals with undetecte...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200206000-00011
更新日期:2002-06-01 00:00:00
abstract:PURPOSE:To determine the long-term intraocular pressure (IOP) control and postoperative complications after initial trabeculectomy with use of mitomycin C (MMC) in patients with primary open-angle glaucoma (POAG). PATIENTS AND METHODS:A retrospective review was conducted of a consecutive series of 123 eyes (87 patient...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212202.57029.45
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To evaluate anxiety felt by glaucoma patients. PATIENTS AND METHODS:In total, 472 glaucoma patients responded to a questionnaire on anxiety, subjective symptoms, and vision-related quality of life (VR-QOL) associated with glaucoma. Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI), state anx...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000761
更新日期:2017-11-01 00:00:00
abstract::PRéCIS:: In primary open-angle glaucoma (POAG), unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density (VD) than with ganglion cell complex (GCC) thickness of the opposite macular hemifield. PURPOSE:The aim of this study was to compare the re...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001441
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181efb371
更新日期:2011-08-01 00:00:00
abstract:PRECIS:Repeated use of the Micropulse P3 (MP3) probe during micropulse transscleral cyclophotocoagulation is associated with an increase in laser output over time. PURPOSE:The purpose of this study was to examine the laser efficacy of the MP3 probe following repeated use. METHODS:This was an observational study carri...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001277
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To investigate levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in the aqueous humor and plasma of patients with pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG), compared with controls. METHODS:This prospective study involved 37 patients with PXS, 15 with PXG, and...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181aae93e
更新日期:2010-03-01 00:00:00
abstract::Glaucoma is a progressive optic neuropathy that is the leading cause of irreversible blindness in the world. Although methods to lower intraocular pressure are the mainstay of glaucoma therapy, there are currently no available treatment modalities targeted at neuroprotection. Erythropoietin is a hematopoietic cytokine...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0b013e318156a556
更新日期:2007-09-01 00:00:00
abstract:PRECIS:Surgeons that perform cataract surgery combined with endocyclophotocoagulation should rely on their preferred IOL calculation formula. There is no need to perform any correction to the IOL power, as this procedure does not modify the refractive outcome. PURPOSE:To compare postoperative refractive outcomes in pa...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001777
更新日期:2020-12-29 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182182567
更新日期:2012-08-01 00:00:00
abstract::A 54-year-old woman who presented with photopsia was found to have elevated intraocular pressure in both eyes and optic disc cupping in the right eye. Angle infiltration was noted on gonioscopy. She was previously been diagnosed with metastatic breast cancer. This case report describes a rare case of glaucoma as a com...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001445
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To compare the effect of unoprostone isopropyl 0.12% to that of timolol maleate 0.5% solution given twice daily on the diurnal curve of intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension. METHODS:In this investigator-masked, single-center, parallel-group comparison, ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-12-01 00:00:00
abstract:PRECIS:Citicoline eyedrops in patients with progressing glaucoma. PURPOSE:This study aimed to test whether the additional therapy with citicoline eyedrops to intraocular pressure (IOP)-lowering treatment could slow glaucoma progression in patients with worsening of damage and IOP 18 mm Hg or less. DESIGN:This was a r...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0000000000001565
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To evaluate and compare the findings and changes of the anterior chamber angle configuration with indentation ultrasound biomicroscopy (UBM) gonioscopy in relative pupillary block (RPB), peripheral anterior synechia (PAS), and plateau iris configuration (PIC). METHODS:This study included 73 eyes of 52 patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000141366.45974.3a
更新日期:2004-12-01 00:00:00
abstract:AIMS:To compare the retinal nerve fiber layer thickness (RNFLT) parameters obtained with newly introduced GDx with enhanced corneal compensation (ECC) and those with GDx with variable corneal compensation (VCC) and to evaluate their reproducibility and the correspondence with visual field damage (VFD) in total or secto...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318133fb47
更新日期:2008-01-01 00:00:00