Quantification of blood--aqueous barrier breakdown after trabeculectomy: pseudoexfoliation versus primary open-angle glaucoma.

Abstract:

PURPOSE:Impairment of the blood-aqueous barrier in unoperated eyes with pseudoexfoliation syndrome has been demonstrated by fluorescein angiography, fluorophotometry, measurement of aqueous flare, and determination of aqueous protein. We performed noninvasive quantification of aqueous flare using the laser flare-cell meter to compare blood-aqueous barrier breakdown after trabeculectomy in eyes with primary open-angle glaucoma (POAG) and in eyes with pseudoexfoliative glaucoma (PEX). METHODS:Twenty eyes with PEX and 20 eyes with POAG were included in the study. Trabeculectomy was performed by two surgeons according to a standard trabeculectomy technique. Intra- and postoperative treatments were identical in both groups. Aqueous flare was quantitatively determined using the laser flare-cell meter FC-1000 (Kowa, Tokyo, Japan) before and 3, 5, 7, and 9 days after trabeculectomy. Absolute flare and difference between post- and preoperative flare values were statistically analyzed using the Mann-Whitney U-Test for independent samples. RESULTS:Before surgery, aqueous flare values were significantly higher in PEX than in POAG. On days 3, 5, 7 and 9 after surgery, flare values were significantly higher in eyes with PEX than in eyes with POAG. Absolute differences between post- and preoperative flare values also were significantly higher in eyes with PEX, but this was not true for percentage values. CONCLUSION:These results show that substantial blood-aqueous barrier breakdown occurs in eyes with PEX after trabeculectomy. These alterations may contribute to early or late complications of trabeculectomy and indicate the need for close postoperative follow-up evaluation in eyes with PEX.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Nguyen NX,Küchle M,Martus P,Naumann GO

keywords:

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

18-23

issue

1

eissn

1057-0829

issn

1536-481X

journal_volume

8

pub_type

杂志文章
  • Dietary ω-3 deficiency and IOP insult are additive risk factors for ganglion cell dysfunction.

    abstract:AIM:Dietary deficiencies in ω-3 polyunsaturated fatty acids are known to effect retinal function including retinal ganglion cell (RGC) activity, which may have implications for glaucoma. In this study we consider retinal function after dietary manipulation and intraocular pressure (IOP) stress designed to compromise RG...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318237cac7

    authors: Nguyen CT,Vingrys AJ,Bui BV

    更新日期:2013-04-01 00:00:00

  • Floppy eyelid syndrome as an indicator of the presence of glaucoma in patients with obstructive sleep apnea.

    abstract:PURPOSE:The aim of the study was to investigate whether floppy eyelid syndrome (FES) could be an indicator of glaucoma in patients with obstructive sleep apnea (OSA). MATERIALS AND METHODS:A total of 152 patients were included: 75 patients with OSA and without FES; 52 patients with OSA and FES; and 25 non-OSA patients...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31829da19f

    authors: Muniesa M,Sánchez-de-la-Torre M,Huerva V,Lumbierres M,Barbé F

    更新日期:2014-01-01 00:00:00

  • Risk Factors Associated With Glaucomatous Progression in Pseudoexfoliation Patients.

    abstract:PURPOSE:To investigate risk factors associated with glaucomatous progression in pseudoexfoliation glaucoma (PXG) patients. PATIENTS AND METHODS:A retrospective observational study with a total of 48 PXG patients and age, sex, and visual field (VF) test mean deviation-matched 48 primary open-angle glaucoma (POAG) patie...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究

    doi:10.1097/IJG.0000000000000791

    authors: Moon Y,Sung KR,Kim JM,Shim SH,Yoo C,Park JH

    更新日期:2017-12-01 00:00:00

  • Surgical Technique for Pars Plana Ahmed Glaucoma Valve Implantation in Advanced Glaucoma: The Upside-Down Technique.

    abstract:PRCIS:Ahmed glaucoma valve implantation using the upside-down technique resulted in an aqueous humor outflow pathway, occurring primarily on the scleral side and secondarily on the conjunctival side, and was effective in treating refractory glaucoma. PURPOSE:To describe the Ahmed glaucoma valve (AGV) surgical techniqu...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001791

    authors: Masuda Y,Saito Y,Oki T,Hayashi T,Takahashi G,Nakano T

    更新日期:2021-01-13 00:00:00

  • Slit-lamp Needling of the Anterior Capsule for Aqueous Misdirection After Hyaloido-zonulectomy and Iridectomy.

    abstract:INTRODUCTION:We present a case of persistent aqueous misdirection, after Ahmed glaucoma valve surgery, despite undergoing an anterior vitrectomy with hyaloido-zonulectomy and iridectomy. CASE REPORT:A 73-year-old female patient, 4 months after phacotrabeculectomy, was referred with persistent high intraocular pressure...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000877

    authors: Mardelli PG,Mardelli ME

    更新日期:2018-04-01 00:00:00

  • Cohort Study of Nonmelanoma Skin Cancer and the Risk of Exfoliation Glaucoma.

    abstract:PRECIS:In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE:The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XF...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001496

    authors: Kang JH,VoPham T,Laden F,Rosner BA,Wirostko B,Ritch R,Wiggs JL,Qureshi A,Nan H,Pasquale LR

    更新日期:2020-06-01 00:00:00

  • A new technique for diode laser cyclophotocoagulation.

    abstract::Destruction of the ciliary body, an option in glaucoma surgical treatment, can be performed using various methods. Laser energy, now the principle source for cyclodestruction, can be delivered in a transpupillar, transvitreal in conjunction with a vitrectomy and transscleral manner. The current technique for endocyclo...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31826981b1

    authors: Vila-Arteaga J,Stirbu O,Suriano MM,Vila-Mascarell E

    更新日期:2014-01-01 00:00:00

  • The Effect of Labor on the Intraocular Pressure in Healthy Women.

    abstract:PURPOSE:To investigate the effect of modern vaginal labor using epidural anesthesia on the intraocular pressure (IOP) and on the mean ocular perfusion pressure (MOPP) in healthy women. PATIENTS AND METHODS:In this prospective observational study, eligible candidates were healthy pregnant women for vaginal delivery wit...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000559

    authors: Meshi A,Armarnik S,Mimouni M,Segev F,Segal O,Kaneti H,Assia EI,Geffen N

    更新日期:2017-01-01 00:00:00

  • Melatonin Levels in Patients With Primary Open-angle Glaucoma With High or Low Intraocular Pressure.

    abstract:PURPOSE:To evaluate circulatory melatonin levels by assessing nocturnal urinary excretion of 6-sulfatoxymelatonin (aMT6s) in patients with primary open-angle glaucoma (POAG) and to compare the high-tension group and the low-tension group. METHODS:This study included 80 eyes of 41 POAG patients and 87 eyes of 44 contro...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001130

    authors: Kim JY,Jeong AR,Chin HS,Kim NR

    更新日期:2019-02-01 00:00:00

  • Change in Intraocular Pressure in the Fellow Eye After Glaucoma Surgery in 1 Eye.

    abstract:PURPOSE:To measure the change in intraocular pressure (IOP) of the fellow eye after glaucoma surgery in 1 eye. PATIENTS AND METHODS:In this prospective interventional study, 71 patients with primary and secondary glaucoma, undergoing glaucoma surgery in 1 eye were included. The IOP in the fellow eye following glaucoma...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000217

    authors: Kaushik S,Agarwal A,Kaur S,Lomi N,Raj S,Pandav SS

    更新日期:2016-03-01 00:00:00

  • Isopropyl unoprostone increases the activities of matrix metalloproteinases in cultured monkey ciliary muscle cells.

    abstract:PURPOSE:The mechanism by which the prostaglandin F2alpha-related antiglaucoma compound isopropyl unoprostone (referred to as unoprostone) reduces intraocular pressure is largely unknown. Another prostaglandin F2alpha-related compound, latanoprost, influences the activities of matrix metalloproteinases in ciliary muscle...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/00061198-200108000-00005

    authors: Kashiwagi K,Jin M,Suzuki M,Tanaka Y,Iizuka Y,Tsukahara S

    更新日期:2001-08-01 00:00:00

  • Additive effect of latanoprost to the combination of timolol and dorzolamide.

    abstract:PURPOSE:To study the additive effect of latanoprost 0.005% in patients who have uncontrolled intraocular pressure (IOP) using timolol 0.5% and dorzolamide 2%. METHODS:Fifty-two consecutive patients with open-angle glaucoma who were using timolol and dorzolamide and were considered to have IOP above their defined targe...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00061198-200004000-00010

    authors: Susanna R Jr,Nicolela MT,Oga E

    更新日期:2000-04-01 00:00:00

  • Use of gonioscopy in medicare beneficiaries before glaucoma surgery.

    abstract:PURPOSE:The American Academy of Ophthalmology Preferred Practice Patterns for angle closure and open-angle glaucoma (OAG) patients recommends performing bilateral gonioscopy upon initial presentation to evaluate the possibility of narrow angle or angle-closure glaucoma (ACG) and then repeating the examination at least ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/01.ijg.0000212287.62798.8f

    authors: Coleman AL,Yu F,Evans SJ

    更新日期:2006-12-01 00:00:00

  • The effect of myopic optical defocus on the humphrey matrix 30-2 threshold test.

    abstract:PURPOSE:To examine the effect of the myopic optical defocus on the Humphrey Matrix 30-2 test. DESIGN:Prospective, nonrandomized, comparative case series. METHODS:Forty eyes from 40 patients with and without glaucoma underwent 2 consecutive tests using the Humphrey Matrix 30-2 threshold program. The first and second t...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181b21ef6

    authors: Kim JH,Kee C

    更新日期:2010-04-01 00:00:00

  • Evaluation of the retinal ganglion cell layer thickness in healthy Turkish children.

    abstract:PURPOSE:To identify the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children measured by high-definition optical coherence tomography (HD-OCT). PATIENTS AND METHODS:This institutional study involved 296 eyes from 296 healthy children aged betwe...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000168

    authors: Totan Y,Gürağaç FB,Güler E

    更新日期:2015-06-01 00:00:00

  • Effect of flunarizine, a calcium channel blocker, on intraocular pressure and aqueous humor dynamics in monkeys.

    abstract:PURPOSE:To evaluate the effects of flunarizine, a nonselective calcium channel blocker, on intraocular pressure (IOP) in monkeys with laser-induced unilateral glaucoma and on aqueous humor dynamics in normal monkeys. METHODS:The IOP was measured before and hourly for 6 hours after single-dose administration of 0.5%, 1...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318133a845

    authors: Wang RF,Gagliuso DJ,Podos SM

    更新日期:2008-01-01 00:00:00

  • Sterile single use cover for the G-probe Transscleral Cyclodiode.

    abstract:PURPOSE:Multiuse of the G-probe transscleral cyclophotocoagulation (TSCPC) device can lead to contamination. We evaluated the mechanical stability and clinical efficacy of a disposable sterile barrier for the G-probe footplate. METHODS:We measured diode laser output with and without the G-probe barrier both before and...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181e08109

    authors: Rootman DB,Howarth D,Kerr JQ,Flanagan JG,Trope GE,Buys YM

    更新日期:2011-04-01 00:00:00

  • Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data: prospective analysis of biophysical parameters in tertiary glaucoma practice populations.

    abstract:PURPOSE:To determine the correlation of central corneal thickness (CCT) to Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT, PASCAL), and to glaucoma stage as assessed by cup-to-disc ratio (CDR). DESIGN:Prospective, cross-sectional tricenter observation study. PATIENTS AND METHODS:From three gl...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00061198-200604000-00003

    authors: Kniestedt C,Lin S,Choe J,Nee M,Bostrom A,Stürmer J,Stamper RL

    更新日期:2006-04-01 00:00:00

  • Phacoemulsification and intraocular lens implantation before, during, or after canaloplasty in eyes with open-angle glaucoma: 3-year results.

    abstract:PURPOSE:To report 3-year results evaluating the effect on safety and efficacy of canaloplasty to treat open-angle glaucoma when combined with cataract surgery. PATIENTS AND METHODS:This was a retrospective subset analysis of a prospective, international, multicenter study evaluating 133 eyes of 133 adult, open-angle g...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究

    doi:10.1097/IJG.0b013e318285ff13

    authors: Tetz M,Koerber N,Shingleton BJ,von Wolff K,Bull H,Samuelson TW,Lewis RA

    更新日期:2015-03-01 00:00:00

  • Ahmed glaucoma valve implantation with tube insertion through the ciliary sulcus in pseudophakic/aphakic eyes.

    abstract:PURPOSE:To report the efficacy and safety of Ahmed glaucoma valve (AGV) insertion into the ciliary sulcus in pseudophakic/aphakic patients. PATIENTS AND METHODS:A chart review was done on patients with uncontrolled glaucoma, who underwent AGV implantation with tube inserted into the ciliary sulcus. Baseline intraocula...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318265bc0b

    authors: Eslami Y,Mohammadi M,Fakhraie G,Zarei R,Moghimi S

    更新日期:2014-02-01 00:00:00

  • Acute angle-closure glaucoma in a patient with miller fisher syndrome without pupillary dysfunction.

    abstract:PURPOSE:To report a case of an angle-closure glaucoma in a patient with Miller Fisher syndrome (MFS) without pupillary dysfunction. METHODS:We present a case report of a 75-year-old male presenting with total ophthalmoplegia, complete bilateral ptosis, and gait disturbance. He was diagnosed with MFS without pupillary ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000191

    authors: Ryu WY,Kim JK,Jin SW,Shim DH

    更新日期:2015-02-01 00:00:00

  • Reoperations for Complications Within 90 Days After Glaucoma Surgery.

    abstract:OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001484

    authors: Chu CK,Liebmann JM,Cioffi GA,Blumberg DM,Al-Aswad LA

    更新日期:2020-05-01 00:00:00

  • Aqueous vascular endothelial growth factor and endothelin-1 levels in branch retinal vein occlusion associated with normal tension glaucoma.

    abstract:PURPOSE:To evaluate aqueous levels of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with branch retinal vein occlusion (BRVO) with and without normal tension glaucoma (NTG), and to assess the therapeutic efficacy of intravitreal bevacizumab (IVB) in these patients. METHODS:Sixteen eyes ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3182312047

    authors: Sin BH,Song BJ,Park SP

    更新日期:2013-02-01 00:00:00

  • Acute Angle Closure Following Implantable Collamer Lens for Myopia.

    abstract::We report a case of acute angle closure with significantly elevated intraocular pressure 9 hours after implantation of a phakic intraocular lens for high myopia. ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001533

    authors: Strungaru MH,González Rodríguez J,Weisbrod DJ,Tayfour F,Buys YM

    更新日期:2020-07-01 00:00:00

  • Effects of tranilast on filtering blebs: a pilot study.

    abstract:PURPOSE:To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS:This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randoml...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00061198-200204000-00008

    authors: Chihara E,Dong J,Ochiai H,Hamada S

    更新日期:2002-04-01 00:00:00

  • "Pseudophakic Reverse Pupillary Block" Following Yamane Technique Scleral-fixated Intraocular Lens.

    abstract:PURPOSE:The authors report a rare complication of "pseudophakic reverse pupillary block" after a secondary, scleral-fixated intraocular lens implantation using the Yamane technique. METHODS/RESULTS:A 52-year-old male patient was referred for uncontrolled intraocular pressure (IOP) despite 3 topical antiglaucoma medica...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001538

    authors: Bharathi M,Balakrishnan D,Senthil S

    更新日期:2020-07-01 00:00:00

  • The trabectome as treatment option in secondary glaucoma due to intraocular lymphoma.

    abstract::Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell de...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31827a0875

    authors: van Oterendorp C,Ness T,Illerhaus G,Neuburger M,Jordan JF

    更新日期:2014-09-01 00:00:00

  • Microbiologic identification of bleb-related delayed-onset endophthalmitis caused by moraxella species.

    abstract:PURPOSE:To report the clinical presentation and outcome of delayed-onset endophthalmitis caused by Moraxella species and to evaluate the eubacterial polymerase chain reaction (PCR) in aqueous humor samples for the microbiologic diagnosis. PATIENTS AND METHODS:Seven patients with bleb-related delayed onset-endophthalmi...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究

    doi:10.1097/IJG.0b013e31816299ec

    authors: Cornut PL,Chiquet C,Bron A,Romanet JP,Lina G,Lafontaine PO,Benito Y,Pechinot A,Burillon C,Vandenesch F,Denis P,FRIENDS Group.

    更新日期:2008-10-01 00:00:00

  • Comparative study of the efficacy of argon laser trabeculoplasty for exfoliation and primary open-angle glaucoma.

    abstract:PURPOSE:To investigate the efficacy of argon laser trabeculoplasty (ALT) for the treatment of primary open-angle glaucoma (POAG) and of glaucoma associated with exfoliation syndrome (EXF). METHODS:Review of > 200 charts from patients treated with ALT between 1981 and 1987 identified 66 POAG and 29 EXF eyes that underw...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:

    authors: Threlkeld AB,Hertzmark E,Sturm RT,Epstein DL,Allingham RR

    更新日期:1996-10-01 00:00:00

  • Prostaglandin efficacy and safety study undertaken by race (the PRESSURE study).

    abstract:PURPOSE:Latanoprost, travoprost, and bimatoprost are prostaglandin or prostamide-type ocular hypotensive medications, all of which are effective and safe for lowering intraocular pressure (IOP). Most studies with these types of drugs have included patients mainly from European or white ethnic backgrounds; however, some...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/IJG.0b013e3181c4aeac

    authors: Birt CM,Buys YM,Ahmed II,Trope GE,Toronto Area Glaucoma Society.

    更新日期:2010-09-01 00:00:00