Abstract:
PURPOSE:To evaluate circulatory melatonin levels by assessing nocturnal urinary excretion of 6-sulfatoxymelatonin (aMT6s) in patients with primary open-angle glaucoma (POAG) and to compare the high-tension group and the low-tension group. METHODS:This study included 80 eyes of 41 POAG patients and 87 eyes of 44 control subjects. POAG group was further classified into high-tension group and low-tension group according to the pretreatment intraocular pressure (IOP). The first urine in the morning was collected and aMT6s were measured using a commercial ELISA kit. Urinary aMT6s levels were expressed as ng aMT6s/mg creatinine. Differences in melatonin levels among the control and POAG subgroups were evaluated by generalized estimating equation adjusting age, sex, sleep duration, and intereye correlation. RESULTS:Urinary aMT6s/creatinine ratio did not differ between POAG and control group (P=0.097). The difference in the aMT6s/creatinine ratio between the 3 groups-high-tension group with baseline IOP≥21 mm Hg (19.74±3.12 ng/mg), low-tension glaucoma group with baseline IOP<21 mm Hg (26.71±3.47 ng/mg), and control group (30.35±3.05 ng/mg)-was statistically significant (P=0.046). Post hoc analysis revealed that the difference between the control and high-tension glaucoma groups was significant (P=0.014), whereas the difference between the control and low-tension glaucoma groups was not (P=0.436). CONCLUSIONS:This study found low melatonin levels in high-tension glaucoma compared with the control.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Kim JY,Jeong AR,Chin HS,Kim NRdoi
10.1097/IJG.0000000000001130subject
Has Abstractpub_date
2019-02-01 00:00:00pages
154-160issue
2eissn
1057-0829issn
1536-481Xjournal_volume
28pub_type
杂志文章abstract:PURPOSE:To evaluate the efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) in primary and pseudoexfoliative open-angle glaucoma. MATERIALS AND METHODS:Patients for primary filtration surgery underwent CLASS with a CO2 laser system (OT-134-IOPtiMate, IOPtima Ltd., Ramat Gan, Israel). This self-controlled system...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/IJG.0b013e3181f7b14f
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To identify the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children measured by high-definition optical coherence tomography (HD-OCT). PATIENTS AND METHODS:This institutional study involved 296 eyes from 296 healthy children aged betwe...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000168
更新日期:2015-06-01 00:00:00
abstract::PRéCIS:: In this study, we report clinical results after implantation of an adjustable glaucoma drainage device. The intraocular pressure (IOP) profile was efficiently controlled postoperatively as the resistance to aqueous humor outflow was finely adjusted. PURPOSE:The main purpose of this study was to evaluate the ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/IJG.0000000000001209
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:This meta-analysis aims to comprehensively evaluate the association between total homocysteine (tHcy) levels, serum folic acid, vitamin B12, vitamin B6 levels, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, and risk of normal-tension glaucoma (NTG). MATERIALS AND METHODS:A systematic search of ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/IJG.0000000000000269
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT). METHODS:In this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181b4caa1
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:To report 2-year results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics, Álava, Spain), a nonabsorbable hema implant, and the morphologic analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS:In tota...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000756
更新日期:2017-10-01 00:00:00
abstract::Exfoliation syndrome (XFS) is considered to be a disease of extracellular matrix. Here we review key experimental evidence of aberrations in structure, expression, and function of glycoproteins, complex carbohydrates, and glycosaminoglycans found in extracellular matrix components forming exfoliation material in patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000000118
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To assess the relationship between pupillary light reflex and estimated retinal ganglion cell (RGC) counts in patients with glaucoma. METHODS:We recorded and analyzed pupil responses using an automated binocular pupillometer in 148 patients with glaucoma (mean age 67±11, 49% female) and 71 controls (age 60±9.6...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001183
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To determine if laser iridotomy altered the anterior segment anatomy of patients with plateau iris configuration. METHODS:Twenty eyes of 9 female and 1 male patients were imaged using an ultrasound biomicroscope within 19 weeks before and 52 weeks after laser iridotomy. Measurements obtained included the anter...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000151687.96785.03
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:The purpose of this study is to describe the outcomes of mitomycin C (MMC)-augmented trabeculectomy performed following a failed MMC-augmented XEN-45 implantation. DESIGN:Retrospective case series. METHODS:All consecutive cases of MMC-augmented trabeculectomy performed after MMC-augmented XEN-45 in the Glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001000
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To report a case of successful intraocular pressure (IOP) reduction after a 360-degree gonioscopy-assisted transluminal trabeculotomy (GATT) using the iTrack catheter in a patient with steroid-induced glaucoma as a result of treatment of vernal keratoconjunctivitis (VKC). MATERIALS AND METHODS:Case report. RE...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001326
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. MATERIALS AND METHODS:This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medic...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000841
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:To compare the efficacy, safety, and long-term results of intraocular pressure (IOP) reduction by diode laser contact cyclophotocoagulation (DCPC) and Ahmed glaucoma valve (AGV) implant in cases of neovascular glaucoma. METHODS:A total of 66 eyes of 66 patients with neovascular glaucoma were prospectively a...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31817d235c
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the changes in longitudinal retinal nerve fiber layer thickness (RNFLT) as determined by spectral-domain optical coherence tomography (OCT) after optic disc hemorrhage (DH) in glaucomatous eyes. METHODS:A total of 65 eyes with unilateral DH and 65 contralateral eyes wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000083
更新日期:2014-10-01 00:00:00
abstract:PRECIS:Ab interno (gonioscopy-assisted transluminal trabeculotomy) and ab externo 360-degree suture trabeculotomy (ST) achieved similar success rates for reducing intraocular pressure (IOP) without serious complications threatening visual acuity. PURPOSE:We aimed to compare the efficacy of ab externo and ab interno 36...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001627
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To determine whether early intraocular pressure (IOP) after mitomycin-C (MMC) augmented trabeculectomy has any predictive value for intermediate IOP outcome. METHODS:Retrospective case note review. All cases of trabeculectomy using MMC augmentation and at least 1-year follow-up during the study period were inc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31805d014a
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate whether glaucoma was related to central corneal thickness (CCT). METHODS:The Beijing Eye Study 2006 is a population-based study that included 3251 (73.3%) subjects (aged 45+y) out of the 4439 subjects who had participated in the survey in 2001, and who returned for a reexa...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181666582
更新日期:2008-12-01 00:00:00
abstract:PURPOSE:Subconjunctival mitomycin C has been used in glaucoma filtration surgery with success. A prospective, randomized, masked, placebo-controlled study was performed to evaluate whether single transconjunctival mitomycin C applied either preoperatively or postoperatively would enhance the success of filtration surge...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:PRECIS:Glycerin-preserved, human-donor, corneoscleral patch grafts are effective and safe for glaucoma drainage device (GDD) implantation, and they are comparable to previously reported materials. It can be preserved with the sterile technique for up to 12 months. PURPOSE:To evaluate the efficacy and safety of glyceri...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001610
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:Traditionally, during trabeculectomy, Mitomycin-C (MMC) is applied to the tissues using surgical sponges. However, alternate modes of application exist. This study assessed the success rates, complication rates, final intraocular pressure (IOP), and bleb characteristics between patients receiving subtenon MMC a...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0000000000000830
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To investigate the relationship between retinal nerve fiber layer (RNFL) measurements in corresponding areas obtained with scanning laser polarimetry and optical coherence tomography and to compare their discriminating ability in the diagnosis of preperimetric and perimetric glaucoma. PATIENTS AND METHODS:Thre...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181a2fc0e
更新日期:2010-02-01 00:00:00
abstract:PURPOSE:Recent studies have found nocturnal reductions in systemic arterial blood pressure associated with progressive visual field loss in glaucoma. Although ocular ischemia has been hypothesized to link these two phenomena, it remains unknown if perfusion of the eye is reduced during the night in patients with glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:To examine the relationship between retinal ganglion cell function measured using pattern electroretinogram optimized for glaucoma screening (PERGLA), retinal nerve fiber layer (RNFL) thickness, and optic nerve head topography. METHODS:Twenty-nine normal, 28 glaucoma, and 37 glaucoma suspect volunteers were en...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31819afb5c
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:Clinical practice guidelines (CPG) are regarded by many as critical communications providing guidance within specific medical fields. Over a decade ago, the first microinvasive glaucoma surgical (MIGS) procedures were introduced. Since then, a number of these novel intraocular pressure controlling surgical...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000820
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). MATERIALS AND METHODS:In this cross-sectional study, 60 white patients were treated w...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000899
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:To determine the optimal OCT-3 scanning protocol. METHODS:Normal subjects, ocular hypertensive, and open-angle glaucoma patients were enrolled. The "fast" RNFL scan protocol consists of 3 consecutive circular scans, each containing 256 A-scans obtained in a single 1.92 second session. The "regular" RNFL scan p...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200404000-00010
更新日期:2004-04-01 00:00:00
abstract:PURPOSE:To estimate the outpatient clinic burden and surgical workload related to glaucoma in Lagos, Nigeria. METHODS:A multicentre study involving the 2 tertiary eye institutions, 7 secondary eye centers with eye care facilities, and the largest private eye hospital in Lagos state, Nigeria. Data on outpatient departm...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0b013e318264cd80
更新日期:2014-01-01 00:00:00
abstract::Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell de...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827a0875
更新日期:2014-09-01 00:00:00
abstract:PRECIS:The use of nylon wicks with fenestrations in nonvalved aqueous shunt surgery significantly reduces intraocular pressure (IOP) and glaucoma medication usage in the immediate postoperative period compared with the use of fenestrations alone. PURPOSE:To compare early postoperative IOP and medication usage in patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001674
更新日期:2021-01-01 00:00:00