Abstract:
PURPOSE:Traditionally, during trabeculectomy, Mitomycin-C (MMC) is applied to the tissues using surgical sponges. However, alternate modes of application exist. This study assessed the success rates, complication rates, final intraocular pressure (IOP), and bleb characteristics between patients receiving subtenon MMC application by sponge versus irrigation. PATIENTS AND METHODS:A total of 100 patients with glaucoma were enrolled and each was randomized to 1 of the 2 treatment groups. Patients underwent trabeculectomy with Ex-PRESS shunt and MMC placement and were followed for 6 months. Complication rates assessed included bleb failure, bleb leaks, bleb encapsulation, and hypotony, amongst others. Additional factors evaluated included bleb morphology, glaucoma drop usage, Fluorouracil (5-FU) application, bleb revision, and subsequent glaucoma surgery. RESULTS:The irrigation method provided greater IOP lowering effects (P=0.03); correspondingly the irrigation group had higher rates of hypotony (P=0.03) but with no significant consequences. Patients who had trabeculectomy/Ex-PRESS alone had greater IOP reduction than those who had concurrent cataract surgery (P<0.001). The sponge group had higher rates of 5-FU use (P=0.007) and higher reoperation rates (P=0.02) when compared with the irrigation group. Success was defined as achieving 4 mm Hg≤IOP≤15 mm Hg without any anatomical bleb failure or subsequent glaucoma surgery. The overall success rate was 87%. CONCLUSIONS:Application of subtenon MMC by irrigation seems to provide improved short-term outcomes compared with application with sponges. With a similar safety profile, the irrigation method provides better IOP control, and decreases the need for further clinical/surgical intervention in the short-term after trabeculectomy. Longer-term studies will be useful in analyzing if these differences persist with time.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Quist MS,Brown N,Bicket AK,Herndon LWdoi
10.1097/IJG.0000000000000830subject
Has Abstractpub_date
2018-02-01 00:00:00pages
148-156issue
2eissn
1057-0829issn
1536-481Xjournal_volume
27pub_type
杂志文章,随机对照试验abstract:PURPOSE:Lasers have been used to treat dysfunctional blebs, but the laser remodeling of blebs that dissect into the palpebral fissure has not been reported. We describe the unique use of krypton green laser to treat dissected blebs and discuss treatment outcomes. PATIENTS AND METHODS:Retrospective review of consecutiv...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200604000-00013
更新日期:2006-04-01 00:00:00
abstract:PURPOSE:Optic disc photographs of 750 patients attending a glaucoma practice were examined to identify focal peripapillary arteriolar narrowing. METHODS:A subgroup of 110 of these patients' photographs, who had also had finger circulation tested for vasospasm to cold, were divided into patients with peripapillary foca...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract:PURPOSE:We assessed vision-related quality of life (VR-QOL) in glaucoma patients and examined the relationship between VR-QOL and indices of visual function and subjective symptoms. PATIENTS AND METHODS:Four hundred seventy-two glaucoma patients completed a questionnaire concerning VR-QOL and subjective symptoms of gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000221
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To determine if treatment with prostaglandin (PG) analogues affects keratocyte density as an indirect measure of extracellular matrix in the corneal stroma. PATIENTS AND METHODS:In this case control study, 129 eyes from 68 patients were examined: 52 eyes had only PG analogue therapy for at least 3 years, 37 ey...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181ca7c7a
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To report the efficacy and safety of inferior 180 degrees goniosynechialysis followed by diode laser peripheral iridoplasty in the treatment of chronic angle-closure glaucoma with total synechial angle closure. METHODS:Five patients with chronic angle-closure glaucoma and total synechial angle closure whose in...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章
doi:10.1097/00061198-200010000-00007
更新日期:2000-10-01 00:00:00
abstract::Scanning laser ophthalmoscopy is capable of producing video fluorescein angiograms with high spatial and temporal resolution. Digital image analysis of these angiograms has been used to produce measures of capillary flow velocities in perimacular capillaries. We have recently utilized the same technique to measure flo...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:Glaucoma drainage implantation in conjunction with Boston Type 1 Keratoprosthesis placement is a surgical option in controlling postoperative glaucoma. The purpose of this study is to report outcomes of combined pars plana vitrectomy and glaucoma drainage implantation with corneal patch graft in Boston Type 1 K...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31829e55f8
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To assess how glaucoma patients use their topical medications. METHODS:142 subjects were tested before an examiner as to how they used their eyedrops. RESULTS:Fifty-six patients (39.4%) used one drop. The number of drops instilled increased with age. The tip of the bottle touched the ocular surface in 78 (54....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Primary intraocular lymphoma can cause an elevation of intraocular pressure (IOP), resulting from infiltration of the trabecular meshwork with neoplastic lymphocytes. More rarely, therapeutic procedures can induce a highly synchronised death of tumor cells, leading to congestion of the trabecular meshwork with cell de...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31827a0875
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To evaluate the incidence of glaucoma and elevation of intraocular pressure (IOP) in patients with inflammatory eye disease. METHODS:Retrospective review of medical records of 391 consecutive patients with uveitis attending a uveitis clinic of an academic Department of Ophthalmology from January 1999 to August...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000146391.77618.d0
更新日期:2004-12-01 00:00:00
abstract:SUMMARY:Subconjunctival fibrosis is one of the major causes of most bleb failures. To inhibit the wound-healing process and to achieve a better intraocular pressure (IOP) lowering effect as well as bleb formation, we performed a sclerostomy using a THC:YAG laser (thulium, holmium, and chromium-doped yttrium-aluminum-ga...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To report the use of slit-lamp-adapted optical coherence tomography (SL-OCT) in imaging 2 patients with Descemet membrane detachment following anterior chamber reformation after trabeculectomy. METHODS:Two patients, with leaking and overfiltering blebs, respectively, developed Descemet detachments after reform...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31819c469e
更新日期:2009-12-01 00:00:00
abstract:PURPOSE:We performed a literature synthesis to identify the full spectrum of compounds implicated in drug-induced, bilateral secondary angle-closure glaucoma (2° ACG). METHODS:Systematic PubMed literature review identified relevant bilateral 2° ACG case reports. We evaluated these reports with both the Naranjo adverse...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000000270
更新日期:2016-02-01 00:00:00
abstract:PRECIS:Hypotony keratopathy is a potential complication of hypotony following trabeculectomy and successful treatment depends on increasing intraocular pressure (IOP). PURPOSE:To evaluate corneal decompensation in patients following trabeculectomy with adjuvant mitomycin C (MMC). We propose "hypotony keratopathy" as a...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001425
更新日期:2020-02-01 00:00:00
abstract::We report a case of tube obstruction of a non valved glaucoma drainage device (Aurolab Aqueous Drainage Implant; AADI) with a dislocated Soemmering's ring leading to a postoperative intraocular pressure (IOP) spike after an initial IOP reduction. A 24 year old male with bilateral aphakia, bilateral secondary glaucoma ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001760
更新日期:2020-12-17 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate whether glaucoma was related to central corneal thickness (CCT). METHODS:The Beijing Eye Study 2006 is a population-based study that included 3251 (73.3%) subjects (aged 45+y) out of the 4439 subjects who had participated in the survey in 2001, and who returned for a reexa...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181666582
更新日期:2008-12-01 00:00:00
abstract:PRECIS:The VisuALL head-mounted perimetry in normal subjects and glaucoma patients had a moderate to strong correlation with the Humphrey Field Analyzer (HFA). PURPOSE:Visual field testing has a vital role in diagnosing and managing glaucoma. The current clinical practice relies on large, table-based testing units. Th...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001670
更新日期:2021-01-01 00:00:00
abstract:PRECIS:In a cohort study of 120,307 participants with 25+ years of follow-up, a history of nonmelanoma skin cancer (NMSC) was associated with a 40% higher exfoliation glaucoma (XFG) risk. PURPOSE:The purpose of this study was to evaluate the relationship between NMSC (a marker of ultraviolet radiation exposure) and XF...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001496
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:We explored the risk factors for glaucoma blindness among adults aged 40 years and above with primary glaucoma in Nigeria. PARTICIPANTS AND METHODS:A total of 13,591 participants aged 40 years and above were examined in the Nigeria Blindness Survey; 682 (5.02%; 95 CI, 4.60%-5.47%) had glaucoma by ISGEO's crite...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000487
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:During the last decades, the Baerveldt Glaucoma Implant (BGI) has proven effective in the surgical treatment of glaucoma. Various surgical procedures have been used for its implantation and these may yield different clinical outcomes and different intraoperative and postoperative complications. We evaluated the...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182447b7c
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:Subconjunctival mitomycin C has been used in glaucoma filtration surgery with success. A prospective, randomized, masked, placebo-controlled study was performed to evaluate whether single transconjunctival mitomycin C applied either preoperatively or postoperatively would enhance the success of filtration surge...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:PURPOSE:To compare near and distance stereoacuity between patients with primary open-angle glaucoma (POAG) and a control group, and to analyze the associations between stereoacuity and POAG severity. METHODS:This cross-sectional study compared near and distance stereoacuity between the POAG and control groups. The dat...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000963
更新日期:2018-06-01 00:00:00
abstract::Our purpose is to document the first case of unilateral mild corneal ectasia developed in an apparently nonpredisposed cornea after topical latanoprost treatment, and its regression after treatment withdrawal. We describe a 44-year-old man with visual impairment in his left eye (OS) and a past medical history of myopi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001660
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:The measurement of intraocular pressure (IOP) by Goldmann applanation tonometry (GAT) is based on assumptions about corneal parameters. To correct for variations in corneal curvature and thickness, a number of equations have been proposed. This study evaluates the in vivo accuracy of these equations from indivi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000588
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). PATIENTS AND METHODS:In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG att...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0b013e3181ca76a9
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the factors that influence the outcome of trabectome surgery. METHODS:This was a retrospective nonrandomized study. Seventy-eight glaucoma patients (86 eyes) who underwent trabectome surgeries and were followed up for more than 12 months were included. We classified ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000743
更新日期:2017-09-01 00:00:00
abstract:PRECIS:The use of nylon wicks with fenestrations in nonvalved aqueous shunt surgery significantly reduces intraocular pressure (IOP) and glaucoma medication usage in the immediate postoperative period compared with the use of fenestrations alone. PURPOSE:To compare early postoperative IOP and medication usage in patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001674
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) compared with classic nonpenetrating deep sclerectomy (NPDS) with implant in medically uncontrolled glaucoma patients. MATERIALS AND METHODS:Patients who underwent primary filtration surgery with CO2 laser system at the time interval be...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000187
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To study the relationship between optic disc hemorrhages and four different groups of medications used in general vascular disease and diabetes. METHODS:The authors screened citizens of the city of Malmö, Sweden who were between 57 and 79 years old (32,918 subjects), in order to find individuals with undetecte...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200206000-00011
更新日期:2002-06-01 00:00:00
abstract::We pose 4 questions for the clinician diagnosing and monitoring glaucoma, and supply evidence-based answers. The first question is: "When do you perform a 10-2 (2-degree grid) visual field (VF) test?" We argue the best answer is: anyone you would do, or have done, a 24-2 (6-degree grid) VF on should have both a 24-2 a...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001010
更新日期:2018-08-01 00:00:00