Corneal Ectasia Induced by Prostaglandin Analogues.

Abstract:

:Our purpose is to document the first case of unilateral mild corneal ectasia developed in an apparently nonpredisposed cornea after topical latanoprost treatment, and its regression after treatment withdrawal. We describe a 44-year-old man with visual impairment in his left eye (OS) and a past medical history of myopic refraction and ocular hypertension with latanoprost treatment, the rest of ocular examination was normal. A decrease in visual acuity was observed with a refractive change. Corneal tomography showed features of mild corneal ectasia in his OS. Topical prostaglandin analogue therapy was removed and replaced by other antiglaucoma topical treatment. Corneal tomography returned to normal, an improvement in the quality of vision was observed and refractive astigmatism recovered to baseline values. This case illustrates that topical latanoprost does affect the matrix metalloproteinases balance in corneal extracellular matrix, and subsequently may produce a corneal weakening. Corneal biomechanical features and corneal stiffness do probably recover after topical prostaglandin analogues withdrawal.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Rodrigo-Rey S,Bolívar G,Arranz-Marquez E,Cañones-Zafra R,Teus MA

doi

10.1097/IJG.0000000000001660

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

e138-e140

issue

12

eissn

1057-0829

issn

1536-481X

journal_volume

29

pub_type

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