Abstract:
PURPOSE:To report 2-year results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics, Álava, Spain), a nonabsorbable hema implant, and the morphologic analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS:In total, 41 eyes of 41 patients with medically uncontrolled open angle glaucoma who underwent DS with the uveoscleral implant were included in this prospective interventional study. Patients were recruited and selected sequentially. All patients were followed at least for 12 months and 36 of them for 24 months. Absolute success was defined as intraocular pressure (IOP)≤18 mm Hg and ≥20% of IOP reduction without topical medication. Relative success was defined with the same criteria but with the addition of any antihypertensive medication. Primary outcomes were IOP decrease in the postoperative stage. Secondary outcomes were number of medication, best-corrected visual acuity changes, rate of goniopuncture, needle revision, and AS-OCT analysis of the bleb area. AS-OCT analysis, using Visante OCT, was performed at 1, 12, and 24 months. RESULTS:Absolute success rate was 68.3% at 12 months and 61.1% at 2 years. Relative success was 78.0% and 71.4%, at 12 and 24 months, respectively. A significant IOP decrease was observed, from 27.3±6.3 to 14.9±4.4 mm Hg at 12 months and 15.3±5.2 mm Hg at 24 months (P<0.001). There was also a significant reduction in the number of medications, dropping from a mean of 2.5 to 0.28 one year and 0.36 two years after the surgery (P<0.001). Main postoperative complications were transient: 4 eyes with seidel phenomenon at 24 hours (10.3%), 3 hyphema (7.7%), and 1 choroidal detachment (2.6%). Mean intrascleral space height, measured by AS-OCT, was 0.78 mm and it showed a significant positive correlation with IOP at 12 months. Neodymium-doped yttrium aluminium garnet laser goniopuncture was performed in 25 eyes (61%) at 12 months and in 27 (66.8%) by 24 months. CONCLUSIONS:DS with the uveoscleral implant is a safe and effective procedure to lower IOP in open angle glaucoma patients. IOP reduction is maintained over 2 years and is correlated to the postoperative height of the intrascleral bleb. Supraciliary implantation reduces intrascleral lake dependency, being a simultaneous drainage alternative to the subconjunctival pathway.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Romera-Romero P,Loscos-Arenas J,Moll-Udina A,Romanic-Bubalo N,Castellvi-Manent J,Valldeperas Xdoi
10.1097/IJG.0000000000000756subject
Has Abstractpub_date
2017-10-01 00:00:00pages
929-935issue
10eissn
1057-0829issn
1536-481Xpii
00061198-201710000-00011journal_volume
26pub_type
杂志文章abstract:PURPOSE:To determine the outcomes of inferonasal Baerveldt glaucoma implant (BGI) surgery. PATIENTS AND METHODS:A retrospective, non-comparative case series of 182 eyes of 182 patients who underwent inferonasal placement of a Baerveldt glaucoma implant. The main outcome measures included intraocular pressure, number o...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ijg.0000195597.30600.27
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:The GDx is a scanning laser polarimeter that assesses peripapillary nerve fiber layer thickness. In addition to the 14 existing outcome parameters, four new parameters have been described recently: the Ellipse Standard Deviation (ESD), the Normalized Superior Area (NSA), the Normalized Inferior Area (NIA) and t...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200402000-00006
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:The American Academy of Ophthalmology Preferred Practice Patterns for angle closure and open-angle glaucoma (OAG) patients recommends performing bilateral gonioscopy upon initial presentation to evaluate the possibility of narrow angle or angle-closure glaucoma (ACG) and then repeating the examination at least ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212287.62798.8f
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:To report the histopathologic and immunohistochemical findings from the iridectomy specimen of a patient with acquired unilateral iris heterochromia due to latanoprost. PATIENT AND METHODS:A 45-year-old woman with open-angle glaucoma and unilateral iris heterochromia was evaluated for uncontrolled intraocular ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200110000-00009
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182182567
更新日期:2012-08-01 00:00:00
abstract::We herein report 2 eyes with significant loss of vision after glaucoma filtering surgery that was accompanied by progressive macular thinning detected on macular optical coherence tomography imaging. The findings provide evidence that progressive retinal ganglion cell loss is one of the causes of visual loss after unc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001202
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:To understand better the relationship between the macular ganglion cell complex (mGCC) thickness and visual field sensitivity assessed by frequency-doubling technology (FDT) perimetry in the standard automated perimetry (SAP) normal hemifields of glaucomatous eyes, a model of preperimetric stage of glaucoma. P...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000281
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of day-long sequential office measurements of intraocular pressure (IOP) to make therapeutic decisions in patients with progressive glaucomatous damage despite apparently 'controlled' IOP. METHODS:We reviewed the records of 93 consecutive glaucoma patients (185 eyes) who underwent se...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000159125.34241.79
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:The purpose of this study is to assess the relationship between serum glucose levels and intraocular pressure (IOP) both in subjects with impaired fasting glucose (IFG) as well as in subjects with diabetes mellitus (DM). MATERIALS AND METHODS:Data of a cross-sectional sample of 18,406 subjects who underwent ro...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000700
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To report 3-year results evaluating the effect on safety and efficacy of canaloplasty to treat open-angle glaucoma when combined with cataract surgery. PATIENTS AND METHODS:This was a retrospective subset analysis of a prospective, international, multicenter study evaluating 133 eyes of 133 adult, open-angle g...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0b013e318285ff13
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To find the dropout rate and identify the clinical characteristics of patients who drop out in the first year of follow-up from a glaucoma clinic. DESIGN:Descriptive hospital-based study at a tertiary hospital eye department. METHODS:Clinical characteristics of consecutive patients newly diagnosed with glauco...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31815768b3
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the outcomes of trabeculectomy with mitomycin-C (MMC) in uveitis associated with Vogt-Koyanagi-Harada disease (VKH). METHODS:Retrospective cohort study included 27 eyes of 15 patients with uveitic glaucoma associated with VKH disease who underwent trabeculectomy with MMC as a first glaucoma proc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000384
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:The authors identify any diurnal intraocular pressure (IOP) variation in healthy Cayo Santiago macaques, as well as Cayo Santiago macaques with normotensive and hypertensive primary open-angle glaucoma (POAG), to further evaluate their potential value as a model for human POAG. METHODS:Twenty-four monkeys (eig...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:The author studied the effects of pupillary dilation on perimetry in a group of glaucomatous patients receiving timolol therapy. PATIENTS AND METHODS:A prospective study compared the visual fields of 23 patients with primary open-angle glaucoma of varying severity (mean defect: 3.84; short-term fluctuation: 1....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract:PURPOSE:To determine whether a structure-function model developed for normal age-related losses of retinal ganglion cells also models the retinal ganglion cell losses in glaucomatous optic neuropathy. METHODS:The model to relate age-related loss of retinal nerve fiber layer thickness and reduced sensitivity for standa...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31820bcfbe
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:To report 2 cases of delayed-onset, bleb-related endophthalmitis induced by Gemella species. METHODS:Interventional case report. RESULTS:Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C. Both patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31818c6f07
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:This study determined the rate of response to latanoprost compared with timolol in patients with glaucoma or ocular hypertension, whether some patients convert from non-responders to responders after more prolonged therapy, and whether this conversion represents a delayed response or random fluctuation. METHOD...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200312000-00004
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:To evaluate the outcome of modified deep sclerectomy [D-lectomy mitomycin C (MMC)] for medically refractory glaucoma patients. METHODS:In a retrospective comparative study, the surgical outcome in 1 eye each of 31 patients who underwent D-lectomy MMC was compared with that of 91 eyes of 91 patients who underwe...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181752cc8
更新日期:2009-02-01 00:00:00
abstract:PURPOSE:To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). PATIENTS AND METHODS:In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG att...
journal_title:Journal of glaucoma
pub_type: 杂志文章,随机对照试验
doi:10.1097/IJG.0b013e3181ca76a9
更新日期:2010-10-01 00:00:00
abstract::A 51-year-old white man presented with multiple episodes of transient painless unilateral vision loss precipitated by sexual intercourse. Examination was significant for closed angles bilaterally. His visual symptoms completely resolved following treatment with laser peripheral iridotomies. ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000165
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to report a case of recurrent conjunctival erosion and XEN Gel Stent exposure after implantation in a primary open-angle glaucoma patient. Minimally invasive glaucoma surgery (MIGS) is a new approach in glaucoma surgery, and there is a lack of published data with regard to the mana...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001146
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To compare the rates of retinal nerve fiber layer (RNFL) thickness loss using optical coherence tomography (OCT) in progressing versus nonprogressing eyes using 4 methods to define functional progression. METHODS:Normal and glaucomatous eyes with ≥3 years of follow up were prospectively enrolled. Standard auto...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182071cc7
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:To determine the clinical features of optic disc progression in patients with ocular hypertension and early glaucoma. PATIENTS:A total of 336 eyes of 168 patients with ocular hypertension or early glaucoma. METHODS:Two glaucoma specialists independently graded the baseline and most recent optic disc photograp...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824c9251
更新日期:2013-06-01 00:00:00
abstract::Treatment with noncardioselective beta-adrenoceptor antagonists (e.g., 0.5% timolol or 0.5% levobunolol) is standard practice for lowering elevated intraocular pressure (IOP). However, because there are risks and side effects associated with the use of these agents, a lower, yet still effective, dose may be preferred....
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-199201040-00005
更新日期:1992-01-01 00:00:00
abstract::The modern version of trabeculectomy is associated with a very high success rate. As time progresses after surgery, failure of filtration, however, is common, as are problems with filtering blebs such as leaks and dysesthesia. Needle revision of filtering blebs is a useful adjunct to failed, failing, leaking, or dyses...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0b013e318181283e
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181efb371
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. MATERIALS AND METHODS:This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medic...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000841
更新日期:2018-02-01 00:00:00
abstract:PRECIS:Silica nanoparticles (SiNPs), which are potential drug carriers for glaucoma treatment, may induce mild dose-dependent cytotoxicity but not so severe as to compromise a mammalian target of rapamycin (mTOR) pathway in immortalized trabecular meshwork (TM) cells. PURPOSE:Nanoparticle-based ophthalmic drug deliver...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001709
更新日期:2021-02-01 00:00:00
abstract:PURPOSE:To evaluate three new approaches for staging severity of glaucomatous visual field defects using frequency doubling technology. PATIENTS AND METHODS:One hundred and four patients with either ocular hypertension or chronic glaucoma were tested with both standard automated perimetry (SAP, 30-2 Humphrey threshold...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200310000-00004
更新日期:2003-10-01 00:00:00
abstract::We pose 4 questions for the clinician diagnosing and monitoring glaucoma, and supply evidence-based answers. The first question is: "When do you perform a 10-2 (2-degree grid) visual field (VF) test?" We argue the best answer is: anyone you would do, or have done, a 24-2 (6-degree grid) VF on should have both a 24-2 a...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001010
更新日期:2018-08-01 00:00:00