Abstract:
PURPOSE:To investigate the relationship between retinal nerve fiber layer (RNFL) measurements in corresponding areas obtained with scanning laser polarimetry and optical coherence tomography and to compare their discriminating ability in the diagnosis of preperimetric and perimetric glaucoma. PATIENTS AND METHODS:Three hundred eighty-six subjects-57 healthy controls, 145 ocular hypertensive patients, 89 with preperimetric glaucoma, and 95 with perimetric glaucoma-were recruited from the Erlangen Glaucoma Registry. Perimetry, 24-hours intraocular pressure profile, stereographic optic disc slides, optical coherence tomography StratusOCT, and scanning laser polarimetry GDx VCC (Carl Zeiss Meditec, Inc, Dublin, CA) were performed in all patients. Receiver operating characteristic (ROC) curves were constructed for mean RNFL values, sector data, and indices. Sensitivity was estimated at >or=90% and >or=80% of specificity to compare the discriminating ability of each imaging modality. RESULTS:For discrimination between glaucomatous and healthy eyes in GDx VCC the nerve fiber index demonstrated the largest area under the ROC curve (AUROC) (0.962+/-0.013), whereas in StratusOCT the largest AUROC (0.986+/-0.006) was found in the inferior quadrant. For preperimetric glaucoma detection the nerve fiber index achieved the largest AUROC (0.783+/-0.037). In contrast, the total RNFL average obtained using StratusOCT showed the largest AUROC (0.904+/-0.025). Bland-Altman plots showed good agreement between both instruments. CONCLUSIONS:Both the GDx VCC and StratusOCT demonstrate increasing RNFL loss with advanced glaucomatous damage and were comparable in the diagnosis of perimetric glaucoma. Preperimetric glaucomatous damage may be better assessed by StratusOCT.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Schrems WA,Mardin CY,Horn FK,Juenemann AG,Laemmer Rdoi
10.1097/IJG.0b013e3181a2fc0esubject
Has Abstractpub_date
2010-02-01 00:00:00pages
83-94issue
2eissn
1057-0829issn
1536-481Xjournal_volume
19pub_type
杂志文章abstract:PURPOSE:To compare the difference between 2 methods of measuring the intraocular pressure (IOP), namely, Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT) and to study the relationship with the corneal parameters in patients with no glaucoma signs. METHODS:One hundred and eighteen eyes of 118 he...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31816224bd
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182182567
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Upper eyelid sulcus deepening has recently been reported as an adverse effect of prostaglandin (PG) eye drop use. However, no data are available regarding the frequency of upper eyelid sulcus deepening caused by different types of PG eye drops. We used 5 types of PG eye drops in Japanese subjects and examined t...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824d8d7c
更新日期:2013-10-01 00:00:00
abstract::PRéCIS:: In primary open-angle glaucoma (POAG), unlogged mean macular hemifield visual field sensitivity correlates significantly better with superficial capillary vessel density (VD) than with ganglion cell complex (GCC) thickness of the opposite macular hemifield. PURPOSE:The aim of this study was to compare the re...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001441
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To describe findings and utility of optical coherence tomography angiography (OCTA) in optic nerve head drusen (ONHD). OBSERVATIONS:A 57-year-old white man presented with a decrease in contrast sensitivity of the inferior visual field in both eyes. Clinical examination, visual fields, optical coherence tomogra...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000730
更新日期:2017-09-01 00:00:00
abstract::The lamina cribrosa (LC) is a multilayered, collagenous, sieve-like structure at the deep optic nerve head, and is presumed to be the primary site of axonal injury. According to biomechanical theory, intraocular pressure-induced posterior deformation of the LC causes blockage of axonal transport and alters the ocular ...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000000728
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:To evaluate the usefulness of day-long sequential office measurements of intraocular pressure (IOP) to make therapeutic decisions in patients with progressive glaucomatous damage despite apparently 'controlled' IOP. METHODS:We reviewed the records of 93 consecutive glaucoma patients (185 eyes) who underwent se...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000159125.34241.79
更新日期:2005-06-01 00:00:00
abstract:PURPOSE:To determine whether early intraocular pressure (IOP) after mitomycin-C (MMC) augmented trabeculectomy has any predictive value for intermediate IOP outcome. METHODS:Retrospective case note review. All cases of trabeculectomy using MMC augmentation and at least 1-year follow-up during the study period were inc...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31805d014a
更新日期:2007-10-01 00:00:00
abstract:PURPOSE:To investigate corneal viscoelasticity in primary open-angle glaucoma patients with and without diabetes mellitus, and to correlate corneal hysteresis (CH) with central corneal thickness (CCT). METHODS:In this cross-sectional study, 44 primary open-angle glaucoma patients [19 with diabetes (34 eyes) and 25 wit...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181b4caa1
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the factors that influence the outcome of trabectome surgery. METHODS:This was a retrospective nonrandomized study. Seventy-eight glaucoma patients (86 eyes) who underwent trabectome surgeries and were followed up for more than 12 months were included. We classified ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000743
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:The authors quantitatively evaluate the kinetics of fluid transfer from microsurgical sponges in a laboratory model to understand the kinetics of mitomycin C (MMC) delivery. METHODS:The amount of fluid transferred from soaked methylcellulose (Weck-cel, Weck Inc., Durham, NC, U.S.A.) sponges to small pieces of ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract:PURPOSE:The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma. MATERIALS AND METHODS:In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluate...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001141
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To assess the comparative efficacy and safety of primary deep sclerectomy (DS) augmented with subconjunctival Bevacizumab and intraoperative Mitomycin C (MMC). METHODS:Retrospective, comparative case-control series of consecutive primary DS between January 2008 and December 2010. Seventy-five eyes of 73 patien...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182883c0c
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To investigate levels of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in the aqueous humor and plasma of patients with pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG), compared with controls. METHODS:This prospective study involved 37 patients with PXS, 15 with PXG, and...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181aae93e
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:The American Academy of Ophthalmology Preferred Practice Patterns for angle closure and open-angle glaucoma (OAG) patients recommends performing bilateral gonioscopy upon initial presentation to evaluate the possibility of narrow angle or angle-closure glaucoma (ACG) and then repeating the examination at least ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212287.62798.8f
更新日期:2006-12-01 00:00:00
abstract:AIMS:An observational study to determine the safety and efficacy of filtering surgery employing a microlumen aqueous drainage device (InnFocus MicroShunt), used intraoperatively with Mitomycin C, implanted alone or in combination with phacoemulsification. MATERIALS AND METHODS:Single-site, prospective, nonrandomized s...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000368
更新日期:2016-02-01 00:00:00
abstract:SUMMARY:Subconjunctival fibrosis is one of the major causes of most bleb failures. To inhibit the wound-healing process and to achieve a better intraocular pressure (IOP) lowering effect as well as bleb formation, we performed a sclerostomy using a THC:YAG laser (thulium, holmium, and chromium-doped yttrium-aluminum-ga...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. PATIENTS AND METHODS:This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randoml...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200204000-00008
更新日期:2002-04-01 00:00:00
abstract:PURPOSE:We performed a literature synthesis to identify the full spectrum of compounds implicated in drug-induced, bilateral secondary angle-closure glaucoma (2° ACG). METHODS:Systematic PubMed literature review identified relevant bilateral 2° ACG case reports. We evaluated these reports with both the Naranjo adverse...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000000270
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To compare characteristics of functioning blebs (FBs) and nonfunctioning blebs (NFBs) with en-face spectral-domain optical coherence tomography (OCT). METHODS:We evaluated 41 blebs of 38 patients after a first-time trabeculectomy. Eyes were classified into 2 groups: FBs (22 eyes) and NFBs (19 eyes). En-face OC...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000319
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:To classify the appearance of the optic disc seen on fundus photographs of healthy subjects and patients with or suspected glaucoma whose diagnosis was based upon visual fields (VFs) and spectral-domain optical coherence tomography (sdOCT) results. PATIENTS AND METHODS:One eye of 100 patients with or suspected...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000640
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To compare the intraocular pressure-lowering effect of unoprostone isopropyl (unoprostone) 0.12% and latanoprost 0.005%. A correlation between the intraocular pressure-lowering effect of unoprostone and latanoprost was also evaluated. METHODS:A single-masked randomized study included 18 patients between 49 and...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00061198-200112000-00009
更新日期:2001-12-01 00:00:00
abstract::Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-S...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001641
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To evaluate the effects of flunarizine, a nonselective calcium channel blocker, on intraocular pressure (IOP) in monkeys with laser-induced unilateral glaucoma and on aqueous humor dynamics in normal monkeys. METHODS:The IOP was measured before and hourly for 6 hours after single-dose administration of 0.5%, 1...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e318133a845
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001484
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To evaluate anxiety felt by glaucoma patients. PATIENTS AND METHODS:In total, 472 glaucoma patients responded to a questionnaire on anxiety, subjective symptoms, and vision-related quality of life (VR-QOL) associated with glaucoma. Anxiety was evaluated using the State-Trait Anxiety Inventory (STAI), state anx...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000761
更新日期:2017-11-01 00:00:00
abstract:PURPOSE:To investigate the parasympathetic cardiovascular regulation, baroreflex sensitivity (BRS), and pulse wave velocity (PWV) in exfoliation syndrome (XFS). METHODS:Heart rate variability indices [standard deviation of all RR intervals (SDNN); the mean of absolute successive differences (RMSSD); the percentage of ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181379d67
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:The interpretation of changes in serial intraocular pressure (IOP) measurements are critical in the diagnosis and management of glaucoma. Differentiating true change from test-retest variability (TRV) in IOP measurements using Goldmann applanation tonometry (IOPG) is essential when reviewing these measurements....
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000001144
更新日期:2019-04-01 00:00:00
abstract:PURPOSE OF THE STUDY:The purpose of the study was to evaluate the long-term effectiveness and safety profile of Baerveldt glaucoma implant (BGI) in patients with refractory glaucoma operated using a modified technique to avoid postoperative complications. PATIENTS AND METHODS:A total of 160 eyes from 147 glaucomatous ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000488
更新日期:2016-12-01 00:00:00