Aqueous vascular endothelial growth factor and endothelin-1 levels in branch retinal vein occlusion associated with normal tension glaucoma.

Abstract:

PURPOSE:To evaluate aqueous levels of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with branch retinal vein occlusion (BRVO) with and without normal tension glaucoma (NTG), and to assess the therapeutic efficacy of intravitreal bevacizumab (IVB) in these patients. METHODS:Sixteen eyes with NTG of 48 age and sex-matched eyes without NTG that had previously received IVB for BRVO were followed for 6 months. Aqueous VEGF and ET-1 levels were measured by enzyme-linked immunosorbent assay at the time of baseline IVB. Logarithm of the minimum angle of resolution best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at baseline and then at 1, 3, and 6 months postinjection. RESULTS:The obstruction site of BRVO was closer to the optic disk in eyes with NTG compared with controls (P=0.001). Baseline BCVA, CMT, and VEGF levels were similar between the 2 groups. Baseline ET-1 levels were significantly higher in eyes with NTG than those without NTG (P=0.009). After IVB, there was a significant improvement in both BCVA and CMT at 6 months, irrespective of the presence of NTG. However, BCVA in the presence of NTG was significantly worse at 6 months compared with eyes without NTG even though CMT was similarly reduced in both groups (P=0.04). CONCLUSIONS:Aqueous VEGF levels are similar in patients with BRVO with or without NTG, whereas aqueous ET-1 levels are elevated in the presence of NTG. Although IVB may be effective in the treatment of BRVO, the presence of NTG may limit visual recovery despite anatomic recovery of CMT.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Sin BH,Song BJ,Park SP

doi

10.1097/IJG.0b013e3182312047

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

104-9

issue

2

eissn

1057-0829

issn

1536-481X

journal_volume

22

pub_type

杂志文章
  • Detecting early functional damage in glaucoma suspect and ocular hypertensive patients with the multifocal VEP technique.

    abstract:PURPOSE:To determine whether the multifocal visual evoked potential (mfVEP) technique can detect early functional damage in ocular hypertensive (OHT) and glaucoma suspect (GS) patients with normal standard achromatic automated perimetry (SAP) results. PATIENTS AND METHODS:Twenty-five GS patients (25 eyes), 25 patients...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/01.ijg.0000212237.26466.0e

    authors: Thienprasiddhi P,Greenstein VC,Chu DH,Xu L,Liebmann JM,Ritch R,Hood DC

    更新日期:2006-08-01 00:00:00

  • Recurrent Exposure of XEN Gel Stent Implant and Conjunctival Erosion.

    abstract:PURPOSE:The purpose of this study was to report a case of recurrent conjunctival erosion and XEN Gel Stent exposure after implantation in a primary open-angle glaucoma patient. Minimally invasive glaucoma surgery (MIGS) is a new approach in glaucoma surgery, and there is a lack of published data with regard to the mana...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001146

    authors: Arnould L,Theillac V,Moran S,Gatinel D,Grise-Dulac A

    更新日期:2019-03-01 00:00:00

  • A comparison of the ocular hypotensive efficacy of twice-daily 0.25% levobunolol to 0.5% timolol in patients previously treated with 0.5% timolol.

    abstract::Treatment with noncardioselective beta-adrenoceptor antagonists (e.g., 0.5% timolol or 0.5% levobunolol) is standard practice for lowering elevated intraocular pressure (IOP). However, because there are risks and side effects associated with the use of these agents, a lower, yet still effective, dose may be preferred....

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/00061198-199201040-00005

    authors: Beehler CC,Stewart WC,Macdonald DK,Croyle TA,Ostrov CS,Rosanelli EG,Crandall AS,Iacono TL,Lue JC,Kelley EP

    更新日期:1992-01-01 00:00:00

  • Effect of a Short-term Cycle Ergometer Sprint Training Against Heavy and Light Resistances on Intraocular Pressure Responses.

    abstract:PURPOSE:The purpose of this study is to determinate the long-term effect of a cycle ergometer sprint training program against heavy and light resistances on baseline intraocular pressure (IOP), and on the acute IOP response to cycling sprints. METHODS:A total 27 physically active males were randomly assigned to a heav...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/IJG.0000000000000893

    authors: Vera J,Garcia-Ramos A,Redondo B,Cárdenas D,De Moraes CG,Jiménez R

    更新日期:2018-04-01 00:00:00

  • Relationship Between Serum Glucose Levels and Intraocular Pressure, a Population-based Cross-sectional Study.

    abstract:PURPOSE:The purpose of this study is to assess the relationship between serum glucose levels and intraocular pressure (IOP) both in subjects with impaired fasting glucose (IFG) as well as in subjects with diabetes mellitus (DM). MATERIALS AND METHODS:Data of a cross-sectional sample of 18,406 subjects who underwent ro...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000700

    authors: Cohen E,Kramer M,Shochat T,Goldberg E,Krause I

    更新日期:2017-07-01 00:00:00

  • Long-term Glaucoma Treatment with MK-507, Dorzolamide, a Topical Carbonic Anhydrase Inhibitor.

    abstract:PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:

    authors: MK-507 Clinical Study Group.

    更新日期:1995-02-01 00:00:00

  • A 2-hour information session and patient recall has minimal impact on glaucoma-treatment persistence in a mature practice.

    abstract:PURPOSE:To study the impact of a 2-hour information session and 3 patients' phone calls on patient persistence with glaucoma medication. PATIENTS AND METHODS:All patients with glaucoma treatment, part of a 27-year old solo glaucoma practice, were invited to attend the information session. Patients who attended the ses...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3182127a9b

    authors: Blondeau P,Carbonneau M,Esper P,Turcotte PC

    更新日期:2012-08-01 00:00:00

  • Provider Agreement in the Assessment of Glaucoma Progression Within a Team Model.

    abstract:PURPOSE:Glaucoma specialists and optometrists who work in a team model at a single institution utilize a common definition of glaucoma progression and treatment algorithm. The purpose of this study was to assess the consistency of agreement in identifying glaucoma progression among glaucoma specialists and optometrists...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000994

    authors: Shah SM,Choo C,Odden J,Zhao B,Fang C,Schornack M,Stalboerger G,Bennett JR,Khanna CL

    更新日期:2018-08-01 00:00:00

  • Autologous patch graft in tube shunt surgery.

    abstract:PURPOSE:To evaluate an alternate method of covering the subconjunctival portion of the tube in aqueous shunt surgery. Evidence of tube erosion, graft-related infection, graft melting, or other associated intraocular complications were evaluated. METHODS:A retrospective study of 16 patients (17 eyes) who underwent tube...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:

    authors: Aslanides IM,Spaeth GL,Schmidt CM,Lanzl IM,Gandham SB

    更新日期:1999-10-01 00:00:00

  • Imaging of descemet membrane detachment after trabeculectomy using slit-lamp-adapted optical coherence tomography.

    abstract:PURPOSE:To report the use of slit-lamp-adapted optical coherence tomography (SL-OCT) in imaging 2 patients with Descemet membrane detachment following anterior chamber reformation after trabeculectomy. METHODS:Two patients, with leaking and overfiltering blebs, respectively, developed Descemet detachments after reform...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31819c469e

    authors: Palmiero PM,Sbeity Z,Liebmann J,Ritch R

    更新日期:2009-12-01 00:00:00

  • Fluctuation of Bacteria on Bleb Surface After Trabeculectomy With Adjunctive Mitomycin C.

    abstract:PURPOSE:To determine whether the bacterial and floral patterns on the bleb surface are affected by the season in eyes that had undergone trabeculectomy with adjunctive mitomycin C. PATIENTS AND METHODS:Forty-four glaucoma patients who had an avascular or a hypovascular cystic filtering bleb were studied. Swabs of the ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000305

    authors: Takahashi N,Sawada A,Mochizuki K,Katada T,Yamamoto T

    更新日期:2016-05-01 00:00:00

  • Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C.

    abstract:PURPOSE:To report 2 cases of delayed-onset, bleb-related endophthalmitis induced by Gemella species. METHODS:Interventional case report. RESULTS:Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C. Both patie...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31818c6f07

    authors: Sawada A,Mochizuki K,Katada T,Kawakami H,Yamamoto T,Mikamo H,Watanabe K

    更新日期:2009-08-01 00:00:00

  • Can Treatment With Citicoline Eyedrops Reduce Progression in Glaucoma? The Results of a Randomized Placebo-controlled Clinical Trial.

    abstract:PRECIS:Citicoline eyedrops in patients with progressing glaucoma. PURPOSE:This study aimed to test whether the additional therapy with citicoline eyedrops to intraocular pressure (IOP)-lowering treatment could slow glaucoma progression in patients with worsening of damage and IOP 18 mm Hg or less. DESIGN:This was a r...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/IJG.0000000000001565

    authors: Rossetti L,Iester M,Tranchina L,Ottobelli L,Coco G,Calcatelli E,Ancona C,Cirafici P,Manni G

    更新日期:2020-07-01 00:00:00

  • Outcomes of Nd: YAG Goniopuncture After Viscocanalostomy/Phacoviscocanalostomy.

    abstract:PURPOSE:The aim of this study is to evaluate the safety and efficacy of laser goniopuncture (LGP) to lower intraocular pressure (IOP) post-viscocanalostomy (VC)/phacoviscocanalostomy (PVC). Outcomes include: IOP reduction from pre-LGP levels and the need for further topical antiglaucomatous medication or surgery. PATI...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000333

    authors: Mathews D,Shirodkar AL,Ahnood D,Garrick A

    更新日期:2016-06-01 00:00:00

  • Refractive Outcomes of Cataract Surgery With or Without Endocyclophotocoagulation.

    abstract:PRECIS:Surgeons that perform cataract surgery combined with endocyclophotocoagulation should rely on their preferred IOL calculation formula. There is no need to perform any correction to the IOL power, as this procedure does not modify the refractive outcome. PURPOSE:To compare postoperative refractive outcomes in pa...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001777

    authors: Azses-Halabe Y,Gamiochipi-Arjona JE,Alvarez-Ascencio D,Sarabia-Jáuregui A,Hernández-Monroy KM,Gonzalez-Salinas R,Jiménez-Román J

    更新日期:2020-12-29 00:00:00

  • Outcomes of pars plana glaucoma drainage implant in Boston type 1 keratoprosthesis surgery.

    abstract:PURPOSE:Glaucoma drainage implantation in conjunction with Boston Type 1 Keratoprosthesis placement is a surgical option in controlling postoperative glaucoma. The purpose of this study is to report outcomes of combined pars plana vitrectomy and glaucoma drainage implantation with corneal patch graft in Boston Type 1 K...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31829e55f8

    authors: Huh ES,Aref AA,Vajaranant TS,de la Cruz J,Chau FY,Cortina MS

    更新日期:2014-01-01 00:00:00

  • Early Clinical Results of a Novel Ab Interno Gel Stent for the Surgical Treatment of Open-angle Glaucoma.

    abstract:PURPOSE:To evaluate the intraocular pressure (IOP) lowering effect of the XEN140 microfistula gel stent implant for the surgical treatment of open-angle glaucoma. PATIENTS AND METHODS:Forty-nine eyes of 49 patients with an IOP>18 mm Hg and ≤35 mm Hg were studied in a prospective nonrandomized multicenter cohort trial ...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/IJG.0000000000000352

    authors: Sheybani A,Dick HB,Ahmed II

    更新日期:2016-07-01 00:00:00

  • Can frequency-doubling technology and short-wavelength automated perimetries detect visual field defects before standard automated perimetry in patients with preperimetric glaucoma?

    abstract:PURPOSE:To assess the ability of frequency-doubling technology (FDT) perimetry and short-wavelength automated perimetry (SWAP) to detect glaucomatous damage in preperimetric glaucoma subjects. PARTICIPANTS:Two hundred seventy-eight eyes of 278 subjects categorized as normal eyes [n=98; intraocular pressure <20 mm Hg, ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31803bbb17

    authors: Ferreras A,Polo V,Larrosa JM,Pablo LE,Pajarin AB,Pueyo V,Honrubia FM

    更新日期:2007-06-01 00:00:00

  • Obstructive Sleep Apnea and Retinal Nerve Fiber Layer Thickness: A Meta-analysis.

    abstract:STUDY OBJECTIVES:The association between obstructive sleep apnea syndrome (OSAS) and retinal nerve fiber layer (RNFL) thickness has been examined in many studies. However, the findings are inconsistent. Our goal is to evaluate the association between OSAS and RNFL thickness by performing a meta-analysis. METHODS:We co...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,meta分析

    doi:10.1097/IJG.0000000000000349

    authors: Zhao XJ,Yang CC,Zhang JC,Zheng H,Liu PP,Li Q

    更新日期:2016-04-01 00:00:00

  • Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial.

    abstract:PURPOSE:To compare the replacement of every drug with latanoprost 0.005% once a day in glaucomatous eyes with poorly controlled intraocular pressure upon combination therapy, versus addition of latanoprost to the pre-existing treatment. PATIENTS AND METHODS: STUDY DESIGN:prospective, investigator-masked, two-center, ...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00061198-200308000-00009

    authors: Gandolfi SA,Rossetti L,Cimino L,Mora P,Tardini M,Orzalesi N

    更新日期:2003-08-01 00:00:00

  • Relationship between pattern electroretinogram, standard automated perimetry, and optic nerve structural assessments.

    abstract:PURPOSE:To examine the relationship between retinal ganglion cell function measured using pattern electroretinogram optimized for glaucoma screening (PERGLA), retinal nerve fiber layer (RNFL) thickness, and optic nerve head topography. METHODS:Twenty-nine normal, 28 glaucoma, and 37 glaucoma suspect volunteers were en...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31819afb5c

    authors: Sehi M,Pinzon-Plazas M,Feuer WJ,Greenfield DS

    更新日期:2009-10-01 00:00:00

  • Comparison of retinal nerve fiber layer thickness measurements using time domain and spectral domain optical coherence tomography, and visual field sensitivity.

    abstract:PURPOSE:To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181efb371

    authors: Takagishi M,Hirooka K,Baba T,Mizote M,Shiraga F

    更新日期:2011-08-01 00:00:00

  • Outcomes of Bleb Revision With Mitomycin C After Ex-PRESS Shunt Surgery.

    abstract:PURPOSE:Investigate efficacy and safety of bleb revision using mitomycin C after Ex-PRESS shunt surgery. PATIENTS AND METHODS:We performed chart reviews of 36 consecutive eyes from 34 patients with previous Ex-PRESS shunt surgery who underwent subsequent bleb revision with mitomycin C. The mean follow-up time was 13.5...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000308

    authors: Allan EJ,Jones JM,Ding K,Khaimi MA

    更新日期:2016-04-01 00:00:00

  • Phaco-viscocanalostomy versus phaco-trabeculotomy: a middle-term study.

    abstract:PURPOSE:To compare the surgical outcomes between phaco-viscocanalostomy and phaco-trabeculotomy in open-angle glaucoma. PATIENTS AND METHODS:In a nonrandomized, retrospective clinical study, 110 eyes underwent phaco-viscocanalostomy (VCS group), and 110 eyes underwent phaco-trabeculotomy (LOT group). The mean follow-u...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/01.ijg.0000212265.96864.77

    authors: Park M,Hayashi K,Takahashi H,Tanito M,Chihara E

    更新日期:2006-10-01 00:00:00

  • Outcomes of bleb excision with free autologous conjunctival patch grafting for bleb leak and hypotony after glaucoma filtering surgery.

    abstract:PURPOSE:To determine the outcomes of bleb excision with free autologous conjunctival patch grafting for bleb leak and hypotony after glaucoma filtering surgery. PATIENTS AND METHODS:Retrospective, consecutive, noncomparative case series. Outcome measures were closure of bleb leak, intraocular pressure (IOP), and best ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181e87efc

    authors: Panday M,Shantha B,George R,Boda S,Vijaya L

    更新日期:2011-08-01 00:00:00

  • Characteristics of peripapillary retinal nerve fiber layer thickness in eyes with myopic optic disc tilt and rotation.

    abstract:PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3182182567

    authors: Hwang YH,Yoo C,Kim YY

    更新日期:2012-08-01 00:00:00

  • A comparison of intraocular pressure-lowering effect of prostaglandin F2 -alpha analogues, latanoprost, and unoprostone isopropyl.

    abstract:PURPOSE:To compare the intraocular pressure-lowering effect of unoprostone isopropyl (unoprostone) 0.12% and latanoprost 0.005%. A correlation between the intraocular pressure-lowering effect of unoprostone and latanoprost was also evaluated. METHODS:A single-masked randomized study included 18 patients between 49 and...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00061198-200112000-00009

    authors: Kobayashi H,Kobayashi K,Okinami S

    更新日期:2001-12-01 00:00:00

  • Glycerin-preserved Human-donor Corneoscleral Patch Grafts for Glaucoma Drainage Devices.

    abstract:PRECIS:Glycerin-preserved, human-donor, corneoscleral patch grafts are effective and safe for glaucoma drainage device (GDD) implantation, and they are comparable to previously reported materials. It can be preserved with the sterile technique for up to 12 months. PURPOSE:To evaluate the efficacy and safety of glyceri...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001610

    authors: Kitnarong N,Srikulsasitorn B,Aurboonsong T

    更新日期:2020-11-01 00:00:00

  • Secondary Epiretinal Membrane After Trabeculectomy.

    abstract:PURPOSE:To determine the frequency of epiretinal membranes (ERM) in eyes with primary open-angle glaucoma subjected to trabeculectomy. METHODS:We conducted a retrospective study on patients subjected to trabeculectomy with at least a 6-month follow-up. Ophthalmologic examination and spectral-domain optical coherence t...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000326

    authors: Vieira L,Cabugueira A,Borges B,Carvalho V,Noronha M,Abegão Pinto L,Reina M,Dutra Medeiros M

    更新日期:2016-06-01 00:00:00

  • Reversal of disc cupping after intraocular pressure reduction in topographic image series.

    abstract:PURPOSE:To identify and characterize 'reversal' of optic nerve cupping following intraocular pressure (IOP) lowering in scanning laser tomography (SLT) longitudinal image series. METHODS:Modification was made to a previously described analytical approach to longitudinally study putatively increased rim area following ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/01.ijg.0000133151.82804.e3

    authors: Tan JC,Hitchings RA

    更新日期:2004-10-01 00:00:00