Abstract：
PURPOSE:To evaluate the intraocular pressure (IOP) lowering effect of the XEN140 microfistula gel stent implant for the surgical treatment of open-angle glaucoma. PATIENTS AND METHODS:Forty-nine eyes of 49 patients with an IOP>18 mm Hg and ≤35 mm Hg were studied in a prospective nonrandomized multicenter cohort trial of the surgical implantation of the XEN140 implant in patients with open-angle glaucoma. Complete success was defined as a postoperative IOP≤18 mm Hg with ≥20% reduction in IOP at 12 months without any glaucoma medications. Failure was defined as vision loss of light perceptions vision or worse, need for additional glaucoma surgery, or <20% reduction of IOP from baseline. RESULTS:The average age was 64.3 (28.1 to 86.9) years old. Twenty-one eyes had prior failed trabeculectomy with mitomycin C surgery. IOP at 12 months decreased from a mean of 23.1 (±4.1) mm Hg to 14.7 (±3.7) mm Hg for a 36.4% reduction in IOP from baseline. The number of patients at 12 months who achieved an IOP≤18 mm Hg and ≥20% reduction in IOP was 40 (89%). The number of patients who achieved an IOP≤18 mm Hg and ≥20% reduction in IOP without antiglaucoma medications was 18 (40%). CONCLUSIONS:The XEN140 gel stent lowers IOP with few complications when implanted for the surgical treatment of open-angle glaucoma.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Sheybani A,Dick HB,Ahmed IIdoi
10.1097/IJG.0000000000000352subject
Has Abstractpub_date
2016-07-01 00:00:00pages
e691-6issue
7eissn
1057-0829issn
1536-481Xjournal_volume
25pub_type
临床试验,杂志文章,多中心研究abstract：PURPOSE:To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP). METHODS:Four hundred twenty-two eyes (78 healthy, 210 suspects, 134 glaucomatous) of 250 patients were recruited from the...
journal_title：Journal of glaucoma
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doi：10.1097/IJG.0b013e31822af27a
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abstract：PURPOSE:To characterize and compare the ocular comfort and symptoms of dorzolamide and tear-replacement drops (placebo) in healthy volunteers. PATIENTS AND METHODS:Subjects were randomized in a double-masked fashion to receive each medicine for 6 days twice daily. Patients used a visual analog scale to assess the qual...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00061198-200304000-00010
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abstract：PURPOSE:To assess the efficacy and safety of botulinum toxin type A (BoNT-A) injection in patients suffering from intractable periorbital pain after acute angle closure glaucoma (AACG). PATIENTS AND METHODS:In this prospective randomized intervention study, 19 patients suffering from periorbital pain after an AACG att...
journal_title：Journal of glaucoma
pub_type： 杂志文章,随机对照试验
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abstract：PURPOSE:To validate the Italian version of the Glaucoma Symptom Scale (GSS) Questionnaire and its symptoms and function subscales. METHODS:This transversal validation study enrolled nonhospitalized patients with glaucoma, and a reference sample of patients without eye diseases. Eligible participants had to be cognitiv...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e318225406c
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abstract：PURPOSE:To study the relationship between optic disc hemorrhages and four different groups of medications used in general vascular disease and diabetes. METHODS:The authors screened citizens of the city of Malmö, Sweden who were between 57 and 79 years old (32,918 subjects), in order to find individuals with undetecte...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00061198-200206000-00011
更新日期：2002-06-01 00:00:00
abstract：PURPOSE:The interpretation of changes in serial intraocular pressure (IOP) measurements are critical in the diagnosis and management of glaucoma. Differentiating true change from test-retest variability (TRV) in IOP measurements using Goldmann applanation tonometry (IOPG) is essential when reviewing these measurements....
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pub_type： 杂志文章,评审
doi：10.1097/IJG.0000000000001144
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journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000984
更新日期：2018-07-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200212000-00014
更新日期：2002-12-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181d9d8bd
更新日期：2011-03-01 00:00:00
abstract：PRECIS:Ab interno (gonioscopy-assisted transluminal trabeculotomy) and ab externo 360-degree suture trabeculotomy (ST) achieved similar success rates for reducing intraocular pressure (IOP) without serious complications threatening visual acuity. PURPOSE:We aimed to compare the efficacy of ab externo and ab interno 36...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001627
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. PATIENTS AND METHODS:Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg ...
journal_title：Journal of glaucoma
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1097/IJG.0000000000000773
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:The purpose of the study was to investigate the effects of myopic optic disc tilt and rotation on peripapillary retinal nerve fiber layer (RNFL) thickness characteristics measured by Cirrus HD spectral-domain optical coherence tomography (Cirrus HD OCT). METHODS:A total of 93 right eyes from 93 healthy young m...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3182182567
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:The purpose of the study was to compare radial peripapillary capillary (RPC) density between normal subjects and patients with early primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCT-A). MATERIALS AND METHODS:A total of 24 patients with early POAG and age-matched 52 normal ...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000649
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:To determine the risk factors for hyphema after trabeculectomy with mitomycin C (MMC). PATIENTS AND METHODS:In total, 420 patients (420 eyes) with glaucoma who underwent trabeculectomy with MMC between June 1, 2005 and December 31, 2010 at Kumamoto University Hospital, Japan, were retrospectively evaluated. Hy...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3182741c85
更新日期：2014-06-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200108000-00005
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:Primary open-angle glaucoma is a significant health-economic burden in both the United States and Europe that is likely to increase. This study compared treatment patterns and cost among patients with primary open-angle glaucoma in these locations. METHODS:Retrospective medical chart reviews were conducted in ...
journal_title：Journal of glaucoma
pub_type： 杂志文章,多中心研究
doi：10.1097/IJG.0b013e3180575202
更新日期：2007-08-01 00:00:00
abstract：:Intraocular pressure (IOP) is a dynamic physiologic parameter with regular circadian variations and unpredictable short-term and long-term fluctuations. Current methods of measuring IOP are suboptimal with a typical clinical practice only performing periodic IOP measurements during regular office hours. Diurnal and 24...
journal_title：Journal of glaucoma
pub_type： 杂志文章,评审
doi：10.1097/IJG.0b013e3181862490
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:The purpose of this study is to describe the outcomes of mitomycin C (MMC)-augmented trabeculectomy performed following a failed MMC-augmented XEN-45 implantation. DESIGN:Retrospective case series. METHODS:All consecutive cases of MMC-augmented trabeculectomy performed after MMC-augmented XEN-45 in the Glauco...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001000
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:To compare the efficacy and tolerability of latanoprost or brimonidine in patients with elevated intraocular pressure (IOP). MATERIALS AND METHODS:This prospective, randomized, masked-evaluator, parallel-group, multicenter study in the United States included patients with primary open angle glaucoma or ocular ...
journal_title：Journal of glaucoma
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2005-04-01 00:00:00
abstract：PURPOSE:To determine if treatment with prostaglandin (PG) analogues affects keratocyte density as an indirect measure of extracellular matrix in the corneal stroma. PATIENTS AND METHODS:In this case control study, 129 eyes from 68 patients were examined: 52 eyes had only PG analogue therapy for at least 3 years, 37 ey...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e3181ca7c7a
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:The purpose of this study is to determinate the long-term effect of a cycle ergometer sprint training program against heavy and light resistances on baseline intraocular pressure (IOP), and on the acute IOP response to cycling sprints. METHODS:A total 27 physically active males were randomly assigned to a heav...
journal_title：Journal of glaucoma
pub_type： 杂志文章,随机对照试验
doi：10.1097/IJG.0000000000000893
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:Subconjunctival mitomycin C has been used in glaucoma filtration surgery with success. A prospective, randomized, masked, placebo-controlled study was performed to evaluate whether single transconjunctival mitomycin C applied either preoperatively or postoperatively would enhance the success of filtration surge...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:To report 2-year results of deep sclerectomy (DS) with mitomycin C and the uveoscleral implant Esnoper-Clip (AJL Ophthalmics, Álava, Spain), a nonabsorbable hema implant, and the morphologic analysis of the surgical area with anterior segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS:In tota...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000756
更新日期：2017-10-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000548
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) compared with classic nonpenetrating deep sclerectomy (NPDS) with implant in medically uncontrolled glaucoma patients. MATERIALS AND METHODS:Patients who underwent primary filtration surgery with CO2 laser system at the time interval be...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000187
更新日期：2016-07-01 00:00:00
abstract：:Treatment with noncardioselective beta-adrenoceptor antagonists (e.g., 0.5% timolol or 0.5% levobunolol) is standard practice for lowering elevated intraocular pressure (IOP). However, because there are risks and side effects associated with the use of these agents, a lower, yet still effective, dose may be preferred....
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-199201040-00005
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To compare the difference between 2 methods of measuring the intraocular pressure (IOP), namely, Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT) and to study the relationship with the corneal parameters in patients with no glaucoma signs. METHODS:One hundred and eighteen eyes of 118 he...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31816224bd
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma. MATERIALS AND METHODS:In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluate...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000001141
更新日期：2019-02-01 00:00:00
