Abstract：
STUDY OBJECTIVES:The association between obstructive sleep apnea syndrome (OSAS) and retinal nerve fiber layer (RNFL) thickness has been examined in many studies. However, the findings are inconsistent. Our goal is to evaluate the association between OSAS and RNFL thickness by performing a meta-analysis. METHODS:We conducted a PubMed database search in November 2014 to identify studies on OSAS and RNFL. Reference lists of retrieved articles were also reviewed. A fixed-effects model was used to compute the summary mean difference (MD). RESULTS:Six studies involving 1034 eyes were included in the meta-analysis. The overall combined MD of RNFL in OSAS patients compared with control participants was -2.03 µm [95% confidence interval (CI), -3.67 to -0.4; P=0.01]. The overall combined MDs of RNFL thickness in relation to moderate OSAS and severe OSAS were -2.49 µm (95% CI: -4.54 to -0.44; P=0.02) and -6.36 µm (95% CI: -8.4 to -4.32; P<0.001). But no significant difference was observed in mild OSAS; the combined MD was -2.05 µm (95% CI: -4.23 to 0.13; P=0.07). Association was also observed in OSAS and RNFL thickness of the inferior quadrant, with a combined MD of -3.31 µm (95% CI: -6.19 to -0.42; P=0.02). CONCLUSIONS:This meta-analysis provides evidence that OSAS is associated with RNFL thickness. Furthermore, it was observed that the greater the severity of OSAS, the greater the loss of RNFL. Among the 4 quadrants observed, the most affected quadrant was the inferior quadrant, and the least affected was the temporal quadrant. OSAS may have an impact on changes in RNFL and therefore more attention should be paid to patients with this condition.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Zhao XJ,Yang CC,Zhang JC,Zheng H,Liu PP,Li Qdoi
10.1097/IJG.0000000000000349subject
Has Abstractpub_date
2016-04-01 00:00:00pages
e413-8issue
4eissn
1057-0829issn
1536-481Xjournal_volume
25pub_type
杂志文章,meta分析abstract：PURPOSE:To evaluate the effect of a latanoprost/timolol fixed combination (LTFC) versus a latanoprost and timolol gel-forming solution unfixed combination (LTuFC) on daytime intraocular pressure (IOP) levels and fluctuations. METHODS:This was an 8-week, randomized, parallel-group study. Ninety eyes of 90 patients diag...
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journal_title：Journal of glaucoma
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abstract：PRCIS:Ahmed glaucoma valve implantation using the upside-down technique resulted in an aqueous humor outflow pathway, occurring primarily on the scleral side and secondarily on the conjunctival side, and was effective in treating refractory glaucoma. PURPOSE:To describe the Ahmed glaucoma valve (AGV) surgical techniqu...
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journal_title：Journal of glaucoma
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更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Upper eyelid sulcus deepening has recently been reported as an adverse effect of prostaglandin (PG) eye drop use. However, no data are available regarding the frequency of upper eyelid sulcus deepening caused by different types of PG eye drops. We used 5 types of PG eye drops in Japanese subjects and examined t...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0b013e31824d8d7c
更新日期：2013-10-01 00:00:00
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journal_title：Journal of glaucoma
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doi：10.1097/IJG.0000000000000217
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doi：10.1097/IJG.0b013e31820bcfbe
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). MATERIALS AND METHODS:In this cross-sectional study, 60 white patients were treated w...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/IJG.0000000000000899
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:To investigate the practice patterns among glaucoma subspecialists in the American Glaucoma Society regarding the management of blebitis. METHODS:An anonymous survey incorporating 14 questions regarding the management of blebitis was mailed to all current active American Glaucoma Society members, including pro...
journal_title：Journal of glaucoma
pub_type： 杂志文章
doi：10.1097/00061198-200108000-00015
更新日期：2001-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1097/IJG.0000000000001144
更新日期：2019-04-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of glaucoma
pub_type： 杂志文章
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更新日期：1998-02-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of glaucoma
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更新日期：2017-05-01 00:00:00
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journal_title：Journal of glaucoma
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更新日期：2016-06-01 00:00:00
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更新日期：2017-03-01 00:00:00
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journal_title：Journal of glaucoma
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
abstract：PURPOSE:To determine the outcomes of inferonasal Baerveldt glaucoma implant (BGI) surgery. PATIENTS AND METHODS:A retrospective, non-comparative case series of 182 eyes of 182 patients who underwent inferonasal placement of a Baerveldt glaucoma implant. The main outcome measures included intraocular pressure, number o...
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pub_type： 杂志文章,多中心研究
doi：10.1097/01.ijg.0000195597.30600.27
更新日期：2006-02-01 00:00:00
