Correlating RNFL thickness by OCT with perimetric sensitivity in glaucoma patients.

Abstract:

PURPOSE:To determine whether a structure-function model developed for normal age-related losses of retinal ganglion cells also models the retinal ganglion cell losses in glaucomatous optic neuropathy. METHODS:The model to relate age-related loss of retinal nerve fiber layer thickness and reduced sensitivity for standard automated perimetry was evaluated with data from 30 glaucoma patients and 40 normal individuals. Perimetry thresholds were translated into separate retinal ganglion cell body estimates for test locations in the superior and inferior visual fields. The retinal nerve fiber layer thickness from optical coherence tomography was also divided into regions representing the superior and inferior hemifields to obtain estimates of the axons in each hemifield. The 2 estimates of retinal ganglion cell populations were compared for corresponding regions. RESULTS:Agreement between neural estimates was good for normal individuals and patients with early glaucomatous damage. Results for individuals with advanced glaucoma showed disparities between neural estimates that were proportional to the stage of disease. A correction factor for the stage of disease was introduced for the derivation of ganglion cell populations from the nerve fiber layer measurements, which produced agreement between the optical coherence tomography and perimetric estimates for all patients. CONCLUSIONS:The modified structure-function model provided well-correlated relationships between the subjective measures of visual sensitivity and the objective measures of retinal nerve fiber layer thickness when parameters for the patient's age and the severity of the disease were included. The results suggest constitutive relationships between structure and function for the full spectrum of normal-to-advanced glaucomatous neuropathy.

journal_name

J Glaucoma

journal_title

Journal of glaucoma

authors

Wheat JL,Rangaswamy NV,Harwerth RS

doi

10.1097/IJG.0b013e31820bcfbe

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

95-101

issue

2

eissn

1057-0829

issn

1536-481X

journal_volume

21

pub_type

杂志文章
  • Modified deep sclerectomy (D-lectomy MMC) for primary open-angle glaucoma: preliminary results.

    abstract:PURPOSE:To evaluate the outcome of modified deep sclerectomy [D-lectomy mitomycin C (MMC)] for medically refractory glaucoma patients. METHODS:In a retrospective comparative study, the surgical outcome in 1 eye each of 31 patients who underwent D-lectomy MMC was compared with that of 91 eyes of 91 patients who underwe...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181752cc8

    authors: Chihara E,Okazaki K,Takahashi H,Shoji T,Adachi H,Hayashi K

    更新日期:2009-02-01 00:00:00

  • Isopropyl unoprostone increases the activities of matrix metalloproteinases in cultured monkey ciliary muscle cells.

    abstract:PURPOSE:The mechanism by which the prostaglandin F2alpha-related antiglaucoma compound isopropyl unoprostone (referred to as unoprostone) reduces intraocular pressure is largely unknown. Another prostaglandin F2alpha-related compound, latanoprost, influences the activities of matrix metalloproteinases in ciliary muscle...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/00061198-200108000-00005

    authors: Kashiwagi K,Jin M,Suzuki M,Tanaka Y,Iizuka Y,Tsukahara S

    更新日期:2001-08-01 00:00:00

  • Imaging visual cortical structure and function in vivo.

    abstract::The recent advent of in vivo two-photon microscopy has allowed the repeat imaging of cortical structures at microscopic resolution within intact brains. Recent data obtained using this imaging technique shows that dendritic spines, the postsynaptic sites of the majority of excitatory synapses in the central nervous sy...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,评审

    doi:10.1097/IJG.0b013e3182934a30

    authors: Majewska AK

    更新日期:2013-06-01 00:00:00

  • Selective Laser Trabeculoplasty in Primary Angle-closure Glaucoma After Laser Peripheral Iridotomy: A Case-Control Study.

    abstract:PURPOSE:To evaluate the outcomes of selective laser trabeculoplasty (SLT) in patients with primary angle closure (PAC/PACG) following a YAG peripheral laser iridotomy (PI) compared with primary open-angle glaucoma (POAG). METHODS:A case-control study compared the effectiveness of SLT in PAC/PACG to POAG. Data from pat...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000282

    authors: Ali Aljasim L,Owaidhah O,Edward DP

    更新日期:2016-03-01 00:00:00

  • Changes in Ocular Hypotensive Drug Usage for Glaucoma Treatment After Cataract Surgery: A Nationwide Population-based Study in Taiwan.

    abstract:PURPOSE:The aims of this study were to observe the changes in the demand for prescriptions of ocular hypertensive drug (OHD) after cataract surgery, to investigate patterns of change in the required OHD amount in open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) cases, and to determine the associated factors r...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000969

    authors: Chang PY,Wang JY,Chang SW,Chang YC

    更新日期:2018-07-01 00:00:00

  • Evaluation of the "IS" Rule to Differentiate Glaucomatous Eyes From Normal.

    abstract:PURPOSE:To compare the accuracy of the "ISNT" rule [neural rim width of inferior(I)≥superior(S)≥nasal(N)≥temporal(T) regions] and the abbreviated variant, the "IS" rule (inferior≥superior regions) to differentiate normal from glaucomatous eyes. MATERIALS AND METHODS:Medical records of patients who were evaluated in 20...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000072

    authors: Law SK,Kornmann HL,Nilforushan N,Moghimi S,Caprioli J

    更新日期:2016-01-01 00:00:00

  • Clinical impact of 8 prospective, randomized, multicenter glaucoma trials.

    abstract:PURPOSE:To determine the impact of 8 multicenter randomized clinical trials (RCTs) on glaucoma practice. METHODS:An electronic survey was distributed to the members of the American Glaucoma Society (AGS). Each participant was asked 2 study-specific questions and 1 standard question common to all 8 RCTs assessing the s...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318295200b

    authors: Panarelli JF,Banitt MR,Sidoti PA,Budenz DL,Singh K

    更新日期:2015-01-01 00:00:00

  • A Population-based Investigation of Circadian Rhythm of Intraocular Pressure in Habitual Position Among Healthy Subjects: The Handan Eye Study.

    abstract:PURPOSE:(1) To investigate the reference value of peak-trough difference in circadian rhythm of intraocular pressure (IOP) in habitual position and (2) to compare the IOP parameters among 3 age groups. MATERIALS AND METHODS:Habitual IOP of healthy subjects sampled from the population in the Handan Eye Study was measur...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000351

    authors: Wang NL,Hao J,Zhen Y,Liu JH,Li SZ,Wang H,Chen H,Peng XX,Han W,Fan SJ,Weinreb RN

    更新日期:2016-07-01 00:00:00

  • Ethnicity and Deprivation are Associated With Blindness Among Adults With Primary Glaucoma in Nigeria: Results From the Nigeria National Blindness and Visual Impairment Survey.

    abstract:PURPOSE:We explored the risk factors for glaucoma blindness among adults aged 40 years and above with primary glaucoma in Nigeria. PARTICIPANTS AND METHODS:A total of 13,591 participants aged 40 years and above were examined in the Nigeria Blindness Survey; 682 (5.02%; 95 CI, 4.60%-5.47%) had glaucoma by ISGEO's crite...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000487

    authors: Kyari F,Wormald R,Murthy GV,Evans JR,Gilbert CE,Nigeria National Blindness and Visual Impairment Study Group.

    更新日期:2016-10-01 00:00:00

  • A new technique for diode laser cyclophotocoagulation.

    abstract::Destruction of the ciliary body, an option in glaucoma surgical treatment, can be performed using various methods. Laser energy, now the principle source for cyclodestruction, can be delivered in a transpupillar, transvitreal in conjunction with a vitrectomy and transscleral manner. The current technique for endocyclo...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31826981b1

    authors: Vila-Arteaga J,Stirbu O,Suriano MM,Vila-Mascarell E

    更新日期:2014-01-01 00:00:00

  • Xen Gel Stent to Resolve Late Hypotony After Glaucoma Drainage Implant Surgery: A Novel Technique.

    abstract:PURPOSE:To describe a new surgical method for treating late profound hypotony in 2 patients with glaucoma drainage implant (GDI). PATIENTS AND METHODS:Two patients, an 85-year-old woman and a 44-year-old woman, presented with choroidal effusions secondary related to chronic hypotony after GDI surgery. A novel techniqu...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001022

    authors: Välimäki J

    更新日期:2018-10-01 00:00:00

  • Meibomian Gland Performance in Glaucomatous Patients With Long-term Instillation of IOP-lowering Medications.

    abstract:PURPOSE:To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications. MATERIALS AND METHODS:This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medic...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000841

    authors: Cho WH,Lai IC,Fang PC,Chien CC,Tseng SL,Lai YH,Huang YT,Kuo MT

    更新日期:2018-02-01 00:00:00

  • Postural response of intraocular pressure and visual field damage in patients with untreated normal-tension glaucoma.

    abstract:PURPOSE:To evaluate whether postural changes of intraocular pressure (IOP) are associated with visual field damage by comparing both eyes of patients with previously untreated normal-tension glaucoma (NTG). PATIENTS AND METHODS:Forty eyes of 20 patients newly diagnosed as bilateral NTG were studied. IOP was measured i...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181a98f30

    authors: Kiuchi T,Motoyama Y,Oshika T

    更新日期:2010-03-01 00:00:00

  • Needle revision of filtering blebs.

    abstract::The modern version of trabeculectomy is associated with a very high success rate. As time progresses after surgery, failure of filtration, however, is common, as are problems with filtering blebs such as leaks and dysesthesia. Needle revision of filtering blebs is a useful adjunct to failed, failing, leaking, or dyses...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章,评审

    doi:10.1097/IJG.0b013e318181283e

    authors: Feldman RM,Tabet RR

    更新日期:2008-10-01 00:00:00

  • Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive mitomycin C.

    abstract:PURPOSE:To report 2 cases of delayed-onset, bleb-related endophthalmitis induced by Gemella species. METHODS:Interventional case report. RESULTS:Two patients developed bleb-related ocular infection attributable to Gemella haemolysans and Gemella morbillorum after trabeculectomy with adjunctive mitomycin C. Both patie...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31818c6f07

    authors: Sawada A,Mochizuki K,Katada T,Kawakami H,Yamamoto T,Mikamo H,Watanabe K

    更新日期:2009-08-01 00:00:00

  • Long-term medical management of primary open-angle glaucoma and ocular hypertension in the UK: optimizing cost-effectiveness and clinic resources by minimizing therapy switches.

    abstract:PURPOSE:The objective was to assess the long-term economic consequences of the medical management of glaucoma in the UK. METHODS:The economic evaluation was conducted using the results from a 10-year Markov model based around 3 key triggers for a switch in medical therapy for glaucoma, namely: lack of tolerance (using...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31821dac2a

    authors: Orme M,Collins S,Loftus J

    更新日期:2012-09-01 00:00:00

  • Recurrent Exposure of XEN Gel Stent Implant and Conjunctival Erosion.

    abstract:PURPOSE:The purpose of this study was to report a case of recurrent conjunctival erosion and XEN Gel Stent exposure after implantation in a primary open-angle glaucoma patient. Minimally invasive glaucoma surgery (MIGS) is a new approach in glaucoma surgery, and there is a lack of published data with regard to the mana...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001146

    authors: Arnould L,Theillac V,Moran S,Gatinel D,Grise-Dulac A

    更新日期:2019-03-01 00:00:00

  • Decreased plasma cortisol in response to intramuscular ACTH in ocular hypertensives and primary open-angle glaucomas.

    abstract:PURPOSE:To determine if there is a difference in response of the adrenal gland to intramuscular adrenocorticotropic hormone (ACTH) between normals and ocular hypertensives (OHs) plus primary open-angle glaucomas (POAGs) without pigmented angles. METHODS:Intramuscular ACTH was given to 29 normals and 24 OH plus POAG ho...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3180334ff6

    authors: Schwartz B,Rabin PA,Wysocki A,Martin J

    更新日期:2007-05-01 00:00:00

  • Ahmed glaucoma valve surgical outcomes in eyes with and without silicone oil endotamponade.

    abstract:PURPOSE:To compare the results of Ahmed glaucoma valve (AGV) implantation in eyes containing silicone oil to those without silicone oil. METHODS:This was a multicenter, retrospective, comparative study of 94 eyes in 94 patients with mean follow-up of 2 years, comparing surgical outcomes in eyes with silicone oil (N=47...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318182ede3

    authors: Ishida K,Ahmed II,Netland PA

    更新日期:2009-04-01 00:00:00

  • Comparison of fluctuations of intraocular pressure before and after selective laser trabeculoplasty in normal-tension glaucoma patients.

    abstract:PURPOSE:The aim of this study was to examine the effects of selective laser trabeculoplasty (SLT) treatment on habitual intraocular pressure (IOP) fluctuations in patients with normal-tension glaucoma (NTG) using a SENSIMED Triggerfish contact lens sensor (CLS). MATERIALS AND METHODS:Ten patients diagnosed with NTG we...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章

    doi:10.1097/IJG.0000000000000026

    authors: Tojo N,Oka M,Miyakoshi A,Ozaki H,Hayashi A

    更新日期:2014-10-01 00:00:00

  • Effect of flunarizine, a calcium channel blocker, on intraocular pressure and aqueous humor dynamics in monkeys.

    abstract:PURPOSE:To evaluate the effects of flunarizine, a nonselective calcium channel blocker, on intraocular pressure (IOP) in monkeys with laser-induced unilateral glaucoma and on aqueous humor dynamics in normal monkeys. METHODS:The IOP was measured before and hourly for 6 hours after single-dose administration of 0.5%, 1...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e318133a845

    authors: Wang RF,Gagliuso DJ,Podos SM

    更新日期:2008-01-01 00:00:00

  • Determinants of adherence to glaucoma medical therapy in a long-term patient population.

    abstract:PURPOSE:Estimate patient adherence to glaucoma medications and identify potential determinants of nonadherence. DESIGN:Descriptive study. METHODS:Two hundred patients with open angle glaucoma, ocular hypertension, or glaucoma suspects were interviewed regarding their glaucoma and its treatment and their charts were r...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e3181815421

    authors: Djafari F,Lesk MR,Harasymowycz PJ,Desjardins D,Lachaine J

    更新日期:2009-03-01 00:00:00

  • Sequential office pressure measurements in the management of glaucoma.

    abstract:PURPOSE:To evaluate the usefulness of day-long sequential office measurements of intraocular pressure (IOP) to make therapeutic decisions in patients with progressive glaucomatous damage despite apparently 'controlled' IOP. METHODS:We reviewed the records of 93 consecutive glaucoma patients (185 eyes) who underwent se...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/01.ijg.0000159125.34241.79

    authors: Collaer N,Zeyen T,Caprioli J

    更新日期:2005-06-01 00:00:00

  • Gonioscopy-assisted Transluminal Trabeculotomy in a Pediatric Patient With Steroid-induced Glaucoma.

    abstract:PURPOSE:To report a case of successful intraocular pressure (IOP) reduction after a 360-degree gonioscopy-assisted transluminal trabeculotomy (GATT) using the iTrack catheter in a patient with steroid-induced glaucoma as a result of treatment of vernal keratoconjunctivitis (VKC). MATERIALS AND METHODS:Case report. RE...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001326

    authors: Hopen ML,Gallardo MJ,Grover D

    更新日期:2019-10-01 00:00:00

  • Glaucoma screening using relative afferent pupillary defect.

    abstract:PURPOSE:To assess the relative afferent pupillary defect (RAPD) by swinging flashlight as a potentially useful screening test for glaucomatous optic neuropathy. METHODS:One hundred seven subjects prospectively recruited from a mixed population of glaucomatous and nonglaucomatous patients were examined for a RAPD by 1 ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0b013e31826a9742

    authors: Charalel RA,Lin HS,Singh K

    更新日期:2014-03-01 00:00:00

  • Characteristics of Patients Receiving Treatment Who Deny A Diagnosis Glaucoma or Elevated Intraocular Pressure in the United States.

    abstract:PURPOSE:The purpose of this study was to determine the proportion of patients in the US population who are receiving long-term intraocular pressure (IOP)-lowering medication, but, deny having a diagnosis of glaucoma or elevated IOP. MATERIALS AND METHODS:The National Health and Nutrition Examination Survey (NHANES) is...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000001035

    authors: Lowry EA,Mansberger SL

    更新日期:2018-11-01 00:00:00

  • Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study.

    abstract:PURPOSE:To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). MATERIALS AND METHODS:In this cross-sectional study, 60 white patients were treated w...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/IJG.0000000000000899

    authors: Agnifili L,Mastropasqua R,Fasanella V,Brescia L,Scatena B,Oddone F,Mastropasqua L

    更新日期:2018-04-01 00:00:00

  • Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial.

    abstract:PURPOSE:To compare the replacement of every drug with latanoprost 0.005% once a day in glaucomatous eyes with poorly controlled intraocular pressure upon combination therapy, versus addition of latanoprost to the pre-existing treatment. PATIENTS AND METHODS: STUDY DESIGN:prospective, investigator-masked, two-center, ...

    journal_title:Journal of glaucoma

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/00061198-200308000-00009

    authors: Gandolfi SA,Rossetti L,Cimino L,Mora P,Tardini M,Orzalesi N

    更新日期:2003-08-01 00:00:00

  • Kinetics of fluid delivery from methylcellulose sponges.

    abstract:PURPOSE:The authors quantitatively evaluate the kinetics of fluid transfer from microsurgical sponges in a laboratory model to understand the kinetics of mitomycin C (MMC) delivery. METHODS:The amount of fluid transferred from soaked methylcellulose (Weck-cel, Weck Inc., Durham, NC, U.S.A.) sponges to small pieces of ...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:

    authors: Brooks SE,Laird ML,Marcus DM,Johnson MH,Ramage JI,Green K

    更新日期:1998-02-01 00:00:00

  • Corneal thickness in congenital glaucoma.

    abstract:PURPOSE:To compare central corneal thickness between eyes with congenital glaucoma and normal controls and to correlate this parameter with corneal diameter and axial length. METHODS:Eyes of consecutive children with congenital glaucoma with previous glaucoma surgery and eyes of children with inadequacy of lacrimal dr...

    journal_title:Journal of glaucoma

    pub_type: 杂志文章

    doi:10.1097/00061198-200406000-00002

    authors: Henriques MJ,Vessani RM,Reis FA,de Almeida GV,Betinjane AJ,Susanna R Jr

    更新日期:2004-06-01 00:00:00