Abstract:
:The recent advent of in vivo two-photon microscopy has allowed the repeat imaging of cortical structures at microscopic resolution within intact brains. Recent data obtained using this imaging technique shows that dendritic spines, the postsynaptic sites of the majority of excitatory synapses in the central nervous system (CNS), rapidly remodel in response to changes in the visual environment. We combined two-photon microscopy of dendritic segments with intrinsic signal imaging of visual cortical responses in the developing ferret visual cortex, and showed that when one eye was deprived during the developmental critical period for ocular dominance plasticity, both dendritic spines and visual responses to the deprived eye were rapidly altered. A brief period of recovery where the eye was re-opened resulted in a return to pre-deprivation levels for both responses and dendritic spine density, showing that structural and functional changes are linked even at very rapid timescales. Additionally, two-photon microscopy can assay other functional and structural aspects of visual cortical function which I will review. Lastly, I will compare this technique to other imaging modalities available for assessment of the visual cortex in vivo.
journal_name
J Glaucomajournal_title
Journal of glaucomaauthors
Majewska AKdoi
10.1097/IJG.0b013e3182934a30subject
Has Abstractpub_date
2013-06-01 00:00:00pages
S21-3eissn
1057-0829issn
1536-481Xpii
00061198-201306001-00011journal_volume
22 Suppl 5pub_type
杂志文章,评审abstract:PURPOSE:To evaluate the diagnostic ability of macular parameters and peripapillary retinal nerve fiber layer (RNFL) parameters for early glaucoma using spectral domain optical coherence tomography (SD-OCT). MATERIALS AND METHODS:One eye from 32 early glaucoma patients (including preperimetric glaucoma) and 32 normal p...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e079ed
更新日期:2011-04-01 00:00:00
abstract:PRCIS:Use of toric intraocular lenses is a reasonable option for better visual outcomes when a combined minimally invasive glaucoma surgery (MIGS) and cataract surgery is performed in eyes with corneal astigmatism. PURPOSE:To assess the efficacy of toric intraocular lenses (IOLs) in combined cataract and MIGS, visual ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001705
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To investigate the efficacy of currently available correction factors in correcting intraocular pressure (IOP) measurements for the errors induced by the normal variations in corneal structural characteristics. MATERIALS AND METHODS:Central corneal thickness (CCT) and corneal radius of curvature were measured ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000176940.81799.33
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To assess the comparative efficacy and safety of primary deep sclerectomy (DS) augmented with subconjunctival Bevacizumab and intraoperative Mitomycin C (MMC). METHODS:Retrospective, comparative case-control series of consecutive primary DS between January 2008 and December 2010. Seventy-five eyes of 73 patien...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3182883c0c
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To assess and compare the impact of medical and surgical glaucoma treatments on patients' health-related Quality of Life (QoL). MATERIALS AND METHODS:We used the 25-question version of the National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) for this cross-sectional study. Patients were divided...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31824ceb8b
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:We assessed vision-related quality of life (VR-QOL) in glaucoma patients and examined the relationship between VR-QOL and indices of visual function and subjective symptoms. PATIENTS AND METHODS:Four hundred seventy-two glaucoma patients completed a questionnaire concerning VR-QOL and subjective symptoms of gl...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究
doi:10.1097/IJG.0000000000000221
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:The pattern of the distribution of nerve fiber layer (NFL) thickness values across the retina may provide an early anatomic indication of glaucomatous disruption. We developed a method of analyzing polarimetry measurements that emphasizes the shape of the pattern of NFL thickness values. Sensitivity and specifi...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200012000-00005
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:Evaluate the long-term results of the Ahmed glaucoma valve (AGV) surgery in association with bevacizumab (Avastin) in neovascular glaucoma (NVG) patients. DESIGN AND METHODS:This retrospective institutional study reviewed 39 eyes of 34 patients with NVG who underwent AGV implantation. The intravitreal bevacizu...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000234
更新日期:2015-06-01 00:00:00
abstract::Exfoliation syndrome (XFS) is considered to be a disease of extracellular matrix. Here we review key experimental evidence of aberrations in structure, expression, and function of glycoproteins, complex carbohydrates, and glycosaminoglycans found in extracellular matrix components forming exfoliation material in patie...
journal_title:Journal of glaucoma
pub_type: 杂志文章,评审
doi:10.1097/IJG.0000000000000118
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181efb371
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To describe reoperations in the operating room for complications encountered within 90 days after glaucoma surgery at a single institution over a 2-year period. DESIGN:Retrospective case series. SUBJECTS:Adult patients who have undergone glaucoma surgery including a tube shunt, trabeculectomy with mitomycin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001484
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of a single treatment of contact diode laser transscleral cyclophotocoagulation (TSCP) on intraocular pressure (IOP) in patients with refractory glaucoma and perform a historical meta-analysis of the relationship between successful IOP control and various laser parameters. METHODS:Clinic...
journal_title:Journal of glaucoma
pub_type: 杂志文章,meta分析
doi:10.1097/00061198-200208000-00009
更新日期:2002-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the long-term efficacy and safety of dorzolamide (a topical carbonic anhydrase inhibitor, previously known as MK-507) as an ocular hypotensive agent. METHODS:This open-labeled, multicenter, 52-week trial enrolled patients with primary open-angle glaucoma or ocular hyper...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:INTRODUCTION:We present a case of persistent aqueous misdirection, after Ahmed glaucoma valve surgery, despite undergoing an anterior vitrectomy with hyaloido-zonulectomy and iridectomy. CASE REPORT:A 73-year-old female patient, 4 months after phacotrabeculectomy, was referred with persistent high intraocular pressure...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000877
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare intraocular pressure measurements obtained with XPERT, an upgraded model of the noncontact tonometer, with those from Goldmann applanation tonometry. METHODS:An average of three intraocular pressure measurements, generated by the XPERT, was compared with a single readin...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:Measurement of intraocular pressure is affected by the shape and thickness of the cornea, and corneal shape is thought to be maintained by contraction of corneal fibroblasts. The effects of the antiglaucoma drugs latanoprost, timolol maleate, and pilocarpine on the contraction of corneal fibroblasts cultured in...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212210.33265.24
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:The aim of the study was to investigate whether floppy eyelid syndrome (FES) could be an indicator of glaucoma in patients with obstructive sleep apnea (OSA). MATERIALS AND METHODS:A total of 152 patients were included: 75 patients with OSA and without FES; 52 patients with OSA and FES; and 25 non-OSA patients...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31829da19f
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To compare the surgical outcomes between phaco-viscocanalostomy and phaco-trabeculotomy in open-angle glaucoma. PATIENTS AND METHODS:In a nonrandomized, retrospective clinical study, 110 eyes underwent phaco-viscocanalostomy (VCS group), and 110 eyes underwent phaco-trabeculotomy (LOT group). The mean follow-u...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/01.ijg.0000212265.96864.77
更新日期:2006-10-01 00:00:00
abstract::PRéCIS:: In this study, we report clinical results after implantation of an adjustable glaucoma drainage device. The intraocular pressure (IOP) profile was efficiently controlled postoperatively as the resistance to aqueous humor outflow was finely adjusted. PURPOSE:The main purpose of this study was to evaluate the ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/IJG.0000000000001209
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To estimate resource use and costs associated with the diagnosis and treatment of glaucoma and ocular hypertension in the Netherlands in 1996 and to determine how costs differed between patients, diagnoses, and hospitals. PATIENTS AND METHODS:Patient characteristics and glaucoma-related resource use were colle...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/00061198-200106000-00007
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:Scarce data are available on the symmetry of 24-hour intraocular pressure (IOP) variations between fellow eyes of glaucoma patients, and such evidence could have profound consequences on the interpretation of monocular therapeutic trials. The objective is to evaluate the intereye correlation of continuously mea...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001563
更新日期:2020-08-01 00:00:00
abstract:PRECIS:Chinese Glaucoma Study Consortium (CGSC) as the first nationwide glaucoma registry in China, we describe its design, rationale, the geographic distribution of the hospitals, and baseline patient characteristics. AIM:As a leading cause of blindness in China, glaucoma affects 2% to 4% of adults over the age of 40...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001378
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Latanoprost, travoprost, and bimatoprost are prostaglandin or prostamide-type ocular hypotensive medications, all of which are effective and safe for lowering intraocular pressure (IOP). Most studies with these types of drugs have included patients mainly from European or white ethnic backgrounds; however, some...
journal_title:Journal of glaucoma
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/IJG.0b013e3181c4aeac
更新日期:2010-09-01 00:00:00
abstract:PRECIS:Ab interno (gonioscopy-assisted transluminal trabeculotomy) and ab externo 360-degree suture trabeculotomy (ST) achieved similar success rates for reducing intraocular pressure (IOP) without serious complications threatening visual acuity. PURPOSE:We aimed to compare the efficacy of ab externo and ab interno 36...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000001627
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:The study investigated the applicability of the inferior≥superior≥nasal≥temporal neuroretinal rim thickness (ISNT) rule to rim thickness measured using Cirrus high-definition spectral-domain optical coherence tomography (Cirrus HD-OCT) in healthy eyes and eyes with glaucoma. METHODS:Rim thicknesses of 4 quadra...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000015
更新日期:2015-09-01 00:00:00
abstract::Destruction of the ciliary body, an option in glaucoma surgical treatment, can be performed using various methods. Laser energy, now the principle source for cyclodestruction, can be delivered in a transpupillar, transvitreal in conjunction with a vitrectomy and transscleral manner. The current technique for endocyclo...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e31826981b1
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Subconjunctival mitomycin C has been used in glaucoma filtration surgery with success. A prospective, randomized, masked, placebo-controlled study was performed to evaluate whether single transconjunctival mitomycin C applied either preoperatively or postoperatively would enhance the success of filtration surge...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:PURPOSE:To evaluate the local variability of anterior chamber angle (ACA) metrics obtained by time domain (TD) and spectral domain (SD) optical coherence tomography (OCT). MATERIALS AND METHODS:Anterior-segment OCT imaging was performed on 30 normal eyes using Visante TD-OCT and 40 normal eyes using Cirrus SD-OCT. For...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0000000000000169
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To compare the effect of unoprostone isopropyl 0.12% to that of timolol maleate 0.5% solution given twice daily on the diurnal curve of intraocular pressure (IOP) in patients with primary open-angle glaucoma or ocular hypertension. METHODS:In this investigator-masked, single-center, parallel-group comparison, ...
journal_title:Journal of glaucoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:To determine the outcomes of bleb excision with free autologous conjunctival patch grafting for bleb leak and hypotony after glaucoma filtering surgery. PATIENTS AND METHODS:Retrospective, consecutive, noncomparative case series. Outcome measures were closure of bleb leak, intraocular pressure (IOP), and best ...
journal_title:Journal of glaucoma
pub_type: 杂志文章
doi:10.1097/IJG.0b013e3181e87efc
更新日期:2011-08-01 00:00:00